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30 recruiting trials

for Chronic Rhinosinusitis With Nasal Polyps

Real Life Study of Biologicals in Patients With Severe CRSwNP NCT05938972n/a1 site๐Ÿ“ Ghent University Hospital, Ghent ยท Tests: Mepolizumab Efficacy and Safety of Fully Resorbable Sinus Drug-eluting Stents in Patients With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps After Surgery: A Prospective, Randomized Controlled Trial NCT07498374NA1 site๐Ÿ“ Xi'an Tang-Du Hospital ยท Tests: the fully degradable sinus stent, intranasal corticosteroids, oral corticosteroids Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis NCT05935683n/a1 site๐Ÿ“ Rozzano Italian Academy of Rhinology ยท Tests: Severe Uncontrolled Chronic Rhinosinusitis patients (CRS) Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps NCT06129552n/a1 site๐Ÿ“ Leuven Universitaire Ziekenhuizen KU Leuven ยท Tests: Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps NCT06850805Phase 324 sites๐Ÿ“ Huntsville๐Ÿ“ Gilbert๐Ÿ“ Los Angeles Optinose US Inc. ยท Tests: OPN-375, Placebo Prospective, Non-interventional Single-arm Study With Tezepelumab to Investigate the Change in Clinical and Patient-reported Outcomes in Patients With CRSwNP in Real-world (PETRICHOR) NCT07633158n/a19 sites๐Ÿ“ Berlin๐Ÿ“ Bochum๐Ÿ“ Braunschweig AstraZeneca Biomarkers of Response to Mepolizumab Treatment in Patients With Nasal Polyps With or Without Bronchial Asthma NCT05708300n/a2 sites๐Ÿ“ Thessaloniki๐Ÿ“ Thessaloniki Aristotle University Of Thessaloniki ยท Tests: Mepolizumab 100 MG [Nucala] A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) NCT07782970Phase 33 sites๐Ÿ“ Los Angeles๐Ÿ“ Tulsa๐Ÿ“ San Juan GlaxoSmithKline ยท Tests: GSK5784283, Placebo, Standard of Care CRS Questionnaire Validation Project NCT06970977n/a32 sites๐Ÿ“ Santa Monica๐Ÿ“ Chicago๐Ÿ“ Boston The European Forum for Research and Education in Allergy anโ€ฆ Implementation of a Joint Pulmonologist and ENT Consultation in the Care Pathway of Patients Suffering From Asthma and Chronic Rhinosinusitis With Nasal Polyposis: Effectiveness Compared With Consultations by Specialty (CON-PO Study). NCT07134686NA1 site๐Ÿ“ Marseille Assistance Publique Hopitaux De Marseille ยท Tests: Joint consultation, Mucus sampling, Nasal brushing Biologics in Chronic Rhinosinusitis With Nasal Polyposis NCT06824649Phase 43 sites๐Ÿ“ Gainesville๐Ÿ“ Portland๐Ÿ“ Charleston Medical University of South Carolina ยท Tests: Biologic Agents A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP) NCT06338995Phase 3202 sites๐Ÿ“ Birmingham๐Ÿ“ Birmingham๐Ÿ“ Huntsville Eli Lilly and Company ยท Tests: LY3650150, Placebo, Standard therapy for INCS Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients. NCT06892704n/a1 site๐Ÿ“ Chicago Northwestern University ยท Tests: Dupilumab - Standard Dose Real-Time Diagnosis of Eosinophilic Nasal Polyps Using High-Sensitivity Spectroscopy NCT07125586NA1 site๐Ÿ“ Qingdao The Affiliated Hospital of Qingdao University ยท Tests: High-Sensitivity Spectroscopy with Autofluorescence for eCRSwNP Diagnosis Efficacy and Safety of SHR-1905 Injection in Subjects With Chronic Rhinosinusitis With Nasal Polyps NCT07132827Phase 31 site๐Ÿ“ Shanghai Guangdong Hengrui Pharmaceutical Co., Ltd ยท Tests: SHR-1905 Injection, SHR-1905 Placebo Injection Mepolizumab and in Office-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS). NCT07814924Phase 47 sites๐Ÿ“ Barakaldo๐Ÿ“ Jerez de la Frontera๐Ÿ“ Madrid Instituto de Investigaciรณn Marquรฉs de Valdecilla ยท Tests: surgical arm, Mepolizumab 100 MG, combined arm Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP NCT05094570Phase 41 site๐Ÿ“ Charlottesville University of Virginia ยท Tests: Dupilumab Prefilled Syringe A Study to Investigate NPS and Symptoms in Chinese Adult Participants With CRSwNP Initiating Treatment With Tezepelumab NCT07520162Phase 334 sites๐Ÿ“ Beijing๐Ÿ“ Beijing๐Ÿ“ Bengbu AstraZeneca ยท Tests: Tezepelumab Complete Remission After Treatment With Biologics for Nasal Polyps NCT07268313Phase 46 sites๐Ÿ“ Copenhagen๐Ÿ“ Hillerรธd๐Ÿ“ Kรธge Copenhagen University Hospital, Rigshospitalet ยท Tests: DUPIXENTยฎ, NUCALAยฎ, Dupi discontinuation, Mepo discontinuation In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps NCT02975310NA4 sites๐Ÿ“ Vancouver๐Ÿ“ London๐Ÿ“ Ottawa Ottawa Hospital Research Institute ยท Tests: Endoscopic polypectomy in clinic (EPIC), Endoscopic Sinus Surgery (ESS), General Anesthesia, Local and topical anesthesโ€ฆ Metabolic and Immunologic Biomarkers in Chronic Rhinosinusitis With Nasal Polyps NCT07860411n/a1 site๐Ÿ“ Sanliurfa Harran University ยท Tests: Nasal polyp tissue and blood sampling, Nasal mucosa and blood sampling A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With or Without Comorbid Asthma NCT07436949Phase 1, Phase 212 sites๐Ÿ“ Beijing๐Ÿ“ Guangzhou๐Ÿ“ Changsha Bambusa Therapeutics ยท Tests: BBT002, Placebo Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training NCT07681973NA1 site๐Ÿ“ Cleveland The Cleveland Clinic ยท Tests: Smell Training ReAl-woRld Evaluation of tEzepelumab for Chronic rhinoSinusitis With Nasal Polyps in Russia NCT07399665n/a10 sites๐Ÿ“ Kazan'๐Ÿ“ Kemerovo๐Ÿ“ Krasnoyarsk AstraZeneca BIOlogics in Severe Nasal POlyposis SurvEy.: a French Registry NCT06501807NA2 sites๐Ÿ“ Lille๐Ÿ“ Lille University Hospital, Lille ยท Tests: Biologic treatments available in Chronic Rhinosinusitis with Nasal Polyps (dupilumab, mepolizumab and benralizumab accoโ€ฆ Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis (CRS). NCT07184684Phase 2, Phase 31 site๐Ÿ“ Helsingborg Region Skane ยท Tests: Sinonasal microbiome transplant procedure., Placebo saline transplant Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis NCT07290140NA16 sites๐Ÿ“ Birmingham๐Ÿ“ Birmingham๐Ÿ“ Huntsville Airiver Medical, Inc. ยท Tests: Airiver ESSpand DCB, ESS Real-life Evaluation of the Efficacy of Biologicals in Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP) NCT06683261n/a8 sites๐Ÿ“ Aalst๐Ÿ“ Bruges๐Ÿ“ Brussels Universitaire Ziekenhuizen KU Leuven ยท Tests: Omalizumab, Dupilumab, Mepolizumab 100 mg Tapering of Biologics in Chronic Rhinosinusitis With Nasal Polyps NCT07187583Phase 49 sites๐Ÿ“ Aalborg๐Ÿ“ Aarhus๐Ÿ“ Copenhagen Copenhagen University Hospital, Rigshospitalet ยท Tests: increased dosing interval of biological therapy Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery NCT06776042NA1 site๐Ÿ“ Brussels Cliniques universitaires Saint-Luc- Universitรฉ Catholique dโ€ฆ ยท Tests: Nasal brushing of the olfactory cleft, Smell testing
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