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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

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30 recruiting trials

for Early-stage HER2+ Breast Cancer

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer NCT01042379Phase 242 sites๐Ÿ“ Birmingham๐Ÿ“ Scottsdale๐Ÿ“ Tucson QuantumLeap Healthcare Collaborative ยท Tests: Standard Therapy, AMG 386 with or without Trastuzumab, AMG 479 (Ganitumab) plus Metformin, MK-2206 with or without Trasโ€ฆ Optimization of Cardiac Imaging in Women With Early-Stage Breast Cancer NCT07630402NA1 site๐Ÿ“ Rochester University of Rochester ยท Tests: Echocardiogram Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies NCT07211178n/a16 sites๐Ÿ“ Birmingham๐Ÿ“ Whittier๐Ÿ“ Weston Tempus AI ยท Tests: There are no interventions in this observational study. Phase II Trial of Anti-HER2 Treatment in HER2-enriched Early Breast Cancer Identified by PAM50 (HER2E-PAM, PAMILIA Study) NCT04817540Phase 21 site๐Ÿ“ Seoul Gangnam Severance Hospital ยท Tests: Herzuma JUdicious Surveillance for Trastuzumab Induced Cardiotoxicity in the First Year NCT06930521NA1 site๐Ÿ“ Toronto Women's College Hospital ยท Tests: Intervention - Low Risk Group OR Intermediate Risk Group Evaluation of [68Ga]Ga-NOTA-anti-HER2-sdAb PET/CT for Predicting Pathological Complete Response After Neoadjuvant Chemotherapy in HER2 Positive Early Breast Cancer NCT07593976Phase 21 site๐Ÿ“ Rouen Centre Henri Becquerel ยท Tests: [68Ga]Ga-NOTA-anti-HER2-sdAb Positron Emission Tomography Dalpicilib-Enhanced vs. Standard Endocrine Therapy in ER+ HER2- Early Breast Cancer NCT06637150Phase 31 site๐Ÿ“ Shanghai Fudan University ยท Tests: Dalpicilib, endocrine therapy A Study to Explore Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of Novel Therapeutics in Patients With Early Relapsed Metastatic Triple-negative Breast Cancer NCT06508216Phase 1, Phase 21 site๐Ÿ“ Villejuif Gustave Roussy, Cancer Campus, Grand Paris ยท Tests: Dato-DXd, Durvalumab Neoadjuvant Adebrelimab and Chemotherapy in High-rish ER+/HER2- BC NCT06500208Phase 21 site๐Ÿ“ Shanghai Shanghai Jiao Tong University School of Medicine ยท Tests: Adebrelimab combined with nab-paclitaxel, epirubicin and cyclophosphamide A Study to Assess Treatment Patterns and Treatment Adherence in Early HER2-positive Breast Cancer Participants After Treatment Decentralization NCT07527741n/a10 sites๐Ÿ“ Loznica๐Ÿ“ Poลพarevac๐Ÿ“ Bor Hoffmann-La Roche Adjuvant Trastuzumab Plus Neratinib in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer After Neoadjuvant Trastuzumab Plus Pertuzumab NCT05760612Phase 31 site๐Ÿ“ Guangzhou Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University ยท Tests: Trastuzumab and neratinib, Trastuzumab and Pertuzumab ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab NCT06876714Phase 3702 sites๐Ÿ“ Phoenix๐Ÿ“ Phoenix๐Ÿ“ Fort Smith Alliance for Clinical Trials in Oncology ยท Tests: Trastuzumab (Herceptin), Pertuzumab, Echocardiography, Multigated Acquisition Scan, Mammography Trastuzumab Combined With Pyrrolidine and Chemotherapy for Locally HER2 Positive Breast Cancer NCT04481932Phase 21 site๐Ÿ“ Beijing Peking University ยท Tests: Trastuzumab combined with Pyrotinib and chemotherapy Neoadjuvant Camrelizumab and Fluzoparib and Nab-paclitaxel in Early Breast Cancer With HRR Gene Mutation NCT05761470Phase 21 site๐Ÿ“ Guangzhou Ying Lin ยท Tests: Camrelizumab, Fluzoparib, Nab-paclitaxel Pyrotinib in Women With High-risk in Early Stage Breast Cancer NCT05834764Phase 21 site๐Ÿ“ Nanjing The First Affiliated Hospital with Nanjing Medical Universiโ€ฆ ยท Tests: Pyrotinib Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial NCT06042569Phase 23 sites๐Ÿ“ Duarte๐Ÿ“ Boston๐Ÿ“ Rochester City of Hope Medical Center ยท Tests: Cyclophosphamide, Docetaxel, Medical Chart Review, Questionnaire Administration Efficacy and Safety of Fluzoparib Combined With Adjuvant Endocrine Therapy for HR+/HER2- SNF3-subtype Early Breast Cancer (BCTOP-L-A01) NCT05891093Phase 315 sites๐Ÿ“ Beijing๐Ÿ“ Chongqing๐Ÿ“ Fuzhou Fudan University ยท Tests: Fluzoparib, Anastrozole, Letrozole, Exemestane, Tamoxifen EC-THP Versus TCbHP in HER2-positive Lymph Node Positive Early Breast Cancer NCT05883852Phase 31 site๐Ÿ“ Shanghai Fudan University ยท Tests: Docetaxel, carboplatin, Trastuzumab, Pertuzumab, Epirubicin Chemotherapy De-escalation in HR +, HER2-, Intermediate-risk Early Breast Cancer Treated With Adjuvant Ribociclib NCT07237256Phase 3138 sites๐Ÿ“ Amiens๐Ÿ“ Angers๐Ÿ“ Argenteuil UNICANCER ยท Tests: Chemotherapy followed by endocrine therapy and ribociclib treatment, De-escalation Serplulimab Combined With Chemotherapy for Early-stage HR+/HER2- Breast Cancer NCT06860529Phase 21 site๐Ÿ“ Zhengzhou Henan Cancer Hospital ยท Tests: Serplulimab, Epirubicin, Albumin Paclitaxel ctDNA-Guided De-Escalation of Adjuvant Chemotherapy With Dalpiciclib in HR-Positive/HER2-Negative Breast Cancer NCT06970912Phase 21 site๐Ÿ“ Beijing Peking University People's Hospital ยท Tests: Dalpiciclib + Aromatase Inhibitor with ctDNA-Guided Therapy, Taxane-Based Neoadjuvant Chemotherapy Dalpiciclib With or Without Entinostat and Letrozole in HR+/HER2- Early Breast Cancer NCT07492394Phase 21 site๐Ÿ“ Shijiazhuang Hebei Medical University Fourth Hospital ยท Tests: entinostat, Dalpiciclib, Letrozole Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy NCT05989347Phase 11 site๐Ÿ“ New Haven Yale University ยท Tests: Dapagliflozin 10mg Ablation Compare With Surgery for Early Breast Cancer NCT07484087NA1 site๐Ÿ“ Beijing Peking University People's Hospital ยท Tests: breast conserving surgery, cryo-thermal ablation Ph2 Study for Optimization of Adjunct Systemic Therapy in HER2+ Patients, MolecularPCR Trial NCT07407920Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Biospecimen Collection, Hormone Therapy, Pembrolizumab, Pertuzumab, Trastuzumab Diagnostic HER2DX-guided Treatment for Patients wIth Early-stage HER2-positive Breast Cancer NCT06446882NA29 sites๐Ÿ“ Graz๐Ÿ“ Leoben๐Ÿ“ Linz Fundacio Clinic Barcelona ยท Tests: Personalized treatment according to molecular diagnosis with HER2DX, Treatment by physicianยดs choice, blinded to the diโ€ฆ Cardiac Side Effects of Systemic Therapy in Early-Stage Breast Cancer NCT07588425n/a1 site๐Ÿ“ Ankara Fatih GURLER Neoadjuvant Trastuzumab-rezetecan Plus Pertuzumab or Nab-Paclitaxel, Carboplatin, Trastuzumab, and Pyrotinib After Suboptimal Response to Neoadjuvant Dual HER2-Targeted Therapy Combined With Chemotherapy in HER2-Positive Early Breast Cancer NCT07340398Phase 21 site๐Ÿ“ Hangzhou Second Affiliated Hospital, Zhejiang University, School of โ€ฆ ยท Tests: Nab paclitaxel, Carboplatin, Trastuzumab, Pertuzumab, SHR-A1811 A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence NCT06492616Phase 3567 sites๐Ÿ“ Daphne๐Ÿ“ Chandler๐Ÿ“ Gilbert Stemline Therapeutics, Inc. ยท Tests: Elacestrant, Anastrozole, Letrozole, Exemestane, Tamoxifen Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer NCT05020860Phase 22 sites๐Ÿ“ Houston๐Ÿ“ Houston Baylor Breast Care Center ยท Tests: Paclitaxel, Carboplatin, Trastuzumab, Pertuzumab, Doxorubicin
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