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30 recruiting trials

for Esophagogastric Adenocarcinoma

To Evaluate the Efficacy of CT041 in Sequential Treatment After First-line Treatment of Advanced Gastric/Esophagogastric Junction Adenocarcinoma NCT07179484n/a1 site๐Ÿ“ Beijing Beijing GoBroad Hospital ยท Tests: CT041 autologous CAR T-cell injection A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique NCT06300879NA1 site๐Ÿ“ Shanghai Huashan Hospital ยท Tests: Performing totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique Molecular Characteristics of Gastroesophageal Adenocarcinoma (MOCHA): A Prospective Feasibility Study NCT04219137n/a1 site๐Ÿ“ Toronto University Health Network, Toronto ยท Tests: Molecular Profiling Evaluation, in Humans, of the Correlation Between Hepatotoxicity, Neurotoxicity Induced by Oxaliplatin, and Blood Levels of HMGB1 NCT06649474NA1 site๐Ÿ“ Clermont-Ferrand University Hospital, Clermont-Ferrand ยท Tests: assess the serum HMGB1 concentrations before and after an oxaliplatin-based chemotherapy Study of Suratadenoturev (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma NCT06340711Phase 22 sites๐Ÿ“ New York๐Ÿ“ Philadelphia Weill Medical College of Cornell University ยท Tests: OBP-301, Pembrolizumab Perioperative Chemotherapy Combined With Serplulimab or Placebo for pMMR Locally Advanced Gastric Adenocarcinoma (FOCUS-05) NCT05872685Phase 25 sites๐Ÿ“ Hangzhou๐Ÿ“ Hangzhou๐Ÿ“ Lishui Yu jiren ยท Tests: S1, Oxaliplatin, Serplulimab, Placebo Neoadjuvant Immunochemotherapy in Locally Advanced Esophagogastric Junction Adenocarcinoma NCT05170503Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Sintilimab Perioperative Treatment of Combined Radiotherapy With SOX, Apatinib and Camrelizumab for Oesophagogastric Cancer NCT07026149Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: Apatinib+Camrelizumab+SOX, Preoperative Radiotherapy Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types NCT06782412Phase 2, Phase 33 sites๐Ÿ“ Edegem๐Ÿ“ Ghent๐Ÿ“ Leuven KU Leuven ยท Tests: [18F]AlF-FAPI-74 PET/CT LM-302 and S-1 Plus Intraperitoneal Paclitaxel With or Without Cadonilimab for Claudin 18.2-positive Gastric or Gastroesophageal Junction Adenocarcinoma With Peritoneal Metastasis: a Prospective, Exploratory Study NCT07556640Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: LM-302, S-1, paclitaxel, LM-302, Cadonilimab, S-1, paclitaxel Neoadjuvant Tislelizumab + LM-302 + S-1 or Tislelizumab + SOX for CLDN18.2-Positive Gastric/GEJ Adenocarcinoma NCT07569068Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: Tislelizumab, LM-302 and S-1, Tislelizumab combined with oxaliplatin and S-1 Perioperative FLOT vs Adjuvant XELOX for CA Stomach NCT05264896Phase 31 site๐Ÿ“ Hong Kong Chinese University of Hong Kong ยท Tests: 5-FU, Leucovorin, Oxaliplatin, Docetaxel, XELOX Anti-PD-1 and CapOx for the First-line Treatment of dMMR Esophagogastric Cancer (AuspiCiOus) NCT05177133Phase 28 sites๐Ÿ“ Amsterdam๐Ÿ“ Amsterdam๐Ÿ“ Eindhoven Academisch Medisch Centrum - Universiteit van Amsterdam (AMโ€ฆ ยท Tests: Capecitabine, Oxaliplatin, Retifanlimab Perioperative Chemotherapy Plus Toripalimab for dMMR Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma NCT05729646Phase 28 sites๐Ÿ“ Hangzhou๐Ÿ“ Hangzhou๐Ÿ“ Huzhou Yu jiren ยท Tests: Toripalimab, Oxaliplatin, S1 A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer or Malignant Peritoneal Mesothelioma NCT06623396Phase 17 sites๐Ÿ“ Basking Ridge๐Ÿ“ Middletown๐Ÿ“ Montvale Memorial Sloan Kettering Cancer Center ยท Tests: M28z1XXPD1DNR CAR A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer NCT06123338Phase 210 sites๐Ÿ“ Boston๐Ÿ“ Basking Ridge๐Ÿ“ Middletown Memorial Sloan Kettering Cancer Center ยท Tests: Pembrolizumab, Trastuzumab, Oxaliplatin, Capecitabine, 5-Fluorouracil An Open Label Phase 2 Study of Total Neoadjuvant Therapy (TNT) Consisting of FLOT With Pembrolizumab and Short Radiation for Patients With Locally Advanced Gastroesophageal Junction Adenocarcinoma NCT07018570Phase 21 site๐Ÿ“ Kashiwa National Cancer Center Hospital East ยท Tests: Pembrolizumab, Docetaxel, Oxaliplatin, Levofolinate, Fluorouracil (5-FU) Total Neoadjuvant Therapy for Lymph Node-positive Adenocarcinoma of the OESophagus and Oesophagogastric Junction NCT06161818Phase 210 sites๐Ÿ“ Eindhoven๐Ÿ“ Leeuwarden๐Ÿ“ Tilburg Erasmus Medical Center ยท Tests: FLOT-CROSS or CROSS-FLOT S-1 and Oxaliplatin (SOX) Plus Sintilimab in the Locally Advanced Esophagogastric Junction Adenocarcinoma NCT04989985Phase 21 site๐Ÿ“ Guangzhou Sixth Affiliated Hospital, Sun Yat-sen University ยท Tests: Oxaliplatin+S-1, Sinitilimab+oxaliplatin+S-1 Perioperative Treatment of Resectable Adenocarcinoma of Esophagogastric Junction by Immunotherapy (Adebrelimab) Combined With Chemotherapy (XELOX): a Prospective, Single-center, Feasibility Study NCT06482788Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: Adebrelimab (anti-PD-L1) + XELOX Perioperative HLX10 (Serplulimab) With S-1+Oxaliplatin (SOX) in Locally Advanced and PD-L1-Positive Gastric or Esophagogastric Junction Adenocarcinoma NCT07699939Phase 218 sites๐Ÿ“ Chiba๐Ÿ“ Fukuoka๐Ÿ“ Gifu National Cancer Center, Japan ยท Tests: serplulimab, Placebo A Study of PD-1 Inhibitors Combined With Fruquintinib and Chemotherapy in First-line Treatment of HER2-negative Advanced G/GEJ Cancer NCT06158919NA1 site๐Ÿ“ Shanghai Fudan University ยท Tests: Fruquintinibใ€Nivolumabใ€Sintilimabใ€Oxaliplatinใ€Teysunoใ€Capecitabine Efficacy and Safety of Anti-PD-1, Thymalfasin, and SOX in Neoadjuvant Treatment of cStage III Gastric/Gastroesophageal Junction Adenocarcinoma NCT06461910Phase 21 site๐Ÿ“ Nanjing Zekuan Xu ยท Tests: Serplulimab, thymalfasin, Oxaliplatin, Tegafur A Phase Ib Trial Evaluating the Safety and Activity of Neoadjuvant Combination of Tislelizumab Plus FLOT for Resectable Esophagogastric Adenocarcinoma NCT07059299Phase 14 sites๐Ÿ“ Frankfurt๐Ÿ“ Hamburg๐Ÿ“ Leipzig Institut fรผr Klinische Krebsforschung IKF GmbH at Krankenhaโ€ฆ ยท Tests: Tislelizumab, FLOT Chemotherapy Right Versus Left Thoracic Surgical Approaches for Siewert II Gastroesophageal Junction Adenocarcinoma NCT06644352NA1 site๐Ÿ“ Beijing Cancer Institute and Hospital, Chinese Academy of Medical Sโ€ฆ ยท Tests: different thoracic surgical approaches Oral TGF-beta Receptor I Inhibitor Vactosertib in SOC Chemoradiotherapy for Esophageal Adenocarcinoma NCT06044311Phase 21 site๐Ÿ“ Cleveland Melissa Lumish ยท Tests: Vactosertib, Standard of Care Preoperative Therapy Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer NCT05514769NA1 site๐Ÿ“ Nanchong Nanchong Central Hospital ยท Tests: Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Perioperative Oxaliplatin With S-1 Combined H. Pylori Eradication in the Management of Locally Advanced Gastric Cancer NCT06510010Phase 21 site๐Ÿ“ Guangzhou Sixth Affiliated Hospital, Sun Yat-sen University ยท Tests: Oxaliplatin With S-1 (SOX) Combined H. Pylori Eradication (Amoxicillin + clarithromycin + omeprazole + colloidal bismutโ€ฆ Adebrelimab With Chemoradiotherapy and Surgery for G/GEJ NCT06985602Phase 21 site๐Ÿ“ Nanjing Jiangsu Cancer Institute & Hospital ยท Tests: Arm 1: Adebrelimab Combined with Chemoradiotherapy Followed by Surgery Folfox+Irinotecan+Chemort In Esophageal Cancer NCT04656041Phase 23 sites๐Ÿ“ Boston๐Ÿ“ Boston๐Ÿ“ Newton Massachusetts General Hospital ยท Tests: FOLFOX/ nal-IRI, Paclitaxel, Carboplatin, Proton Radiation Therapy
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