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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Glioma, High Grade

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion NCT04655404EARLY Phase 121 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Larotrectinib, Larotrectinib surgical rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG NCT04943848Phase 13 sites๐Ÿ“ Orange๐Ÿ“ Chicago๐Ÿ“ Boston Ann & Robert H Lurie Children's Hospital of Chicago ยท Tests: rHSC-DIPGVax, Balstilimab, Zalifrelimab A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations NCT05503797Phase 270 sites๐Ÿ“ Beverly Hills๐Ÿ“ San Francisco๐Ÿ“ Westwood, Los Angeles Fore Biotherapeutics ยท Tests: Plixorafenib CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults NCT06305910Phase 11 site๐Ÿ“ Minneapolis OX2 Therapeutics ยท Tests: Treatment with CD200AR-L Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression NCT06975332NA2 sites๐Ÿ“ Warsaw๐Ÿ“ Warsaw Medical University of Warsaw ยท Tests: Local, targeted therapy with alpha emitter [225Ac]Ac-DOTA-SP (TAT) Bevacizumab Neoadjuvant Therapy for New High-grade Gliomas in the Brain NCT06747728NA1 site๐Ÿ“ Zhengzhou The First Affiliated Hospital of Zhengzhou University ยท Tests: Bevacizumab [177Lu]Lu-DOTA-EB-RGD2 Therapy in Patients With Recurrent High-grade Glioma NCT07655869EARLY Phase 12 sites๐Ÿ“ Beijing๐Ÿ“ Beijing Beijing Tiantan Hospital ยท Tests: [177Lu]Lu-DOTA-EB-RGD2 Study in Children and Adolescents of 177Lu-DOTATATE (Lutatheraยฎ) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). NCT06607692Phase 1, Phase 21 site๐Ÿ“ Boadilla del Monte Fundaciรณn de investigaciรณn HM ยท Tests: Olaparib; 177Lu-DOTATATE Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 NCT06126744Phase 12 sites๐Ÿ“ New York๐Ÿ“ Durham Duke University ยท Tests: MVR-C5252 A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925Phase 13 sites๐Ÿ“ Tampa๐Ÿ“ Chicago๐Ÿ“ New York Tetragon Biosciences Ltd ยท Tests: GLIX1 A Clinical Trial Evaluating the Tolerability, Safety, and Preliminary Efficacy of NRG-103 Injection in Patients With Recurrent or Progressive High-grade Glioma NCT07710690Phase 13 sites๐Ÿ“ Shanghai๐Ÿ“ Wuhan๐Ÿ“ Xi'an Neuregen Therapeutics Co., Ltd. ยท Tests: NRG-103 Metabolomics and Transcriptomics of Low- and High-Grade Gliomas NCT07832734n/a1 site๐Ÿ“ Milan I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion NCT06333899EARLY Phase 118 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2, Lorlatinib post Radiation C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B) NCT04099797Phase 11 site๐Ÿ“ Houston Baylor College of Medicine ยท Tests: C7R-GD2.CART cells (IV and ICV infusion), C7R-GD2.CART cells (IV and ICV infusion) Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients NCT03849430n/a1 site๐Ÿ“ Leuven Universitaire Ziekenhuizen KU Leuven A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma NCT07306299Phase 11 site๐Ÿ“ Hangzhou Second Affiliated Hospital, Zhejiang University, School of โ€ฆ ยท Tests: Glioma-related multi-target mRNA vaccines Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188Phase 1, Phase 21 site๐Ÿ“ Bethesda National Institute of Neurological Disorders and Stroke (NIโ€ฆ ยท Tests: LMP744, Conventional Surgery or Biopsy Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors NCT04299191Phase 1, Phase 23 sites๐Ÿ“ Little Rock๐Ÿ“ Miami๐Ÿ“ Edison Laminar Pharmaceuticals ยท Tests: LAM561 Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases NCT06888817Phase 36 sites๐Ÿ“ Amsterdam๐Ÿ“ Amsterdam๐Ÿ“ Leiden The Netherlands Cancer Institute ยท Tests: Bevacizumab, Dexamethasone Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rฮฑ2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDGโ€ฆ Dabrafenib and/or Trametinib Rollover Study NCT03340506Phase 438 sites๐Ÿ“ Scottsdale๐Ÿ“ Bethesda๐Ÿ“ Columbus Novartis Pharmaceuticals ยท Tests: dabrafenib, trametinib Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) NCT04485559Phase 117 sites๐Ÿ“ Birmingham๐Ÿ“ Los Angeles๐Ÿ“ San Diego University of California, San Francisco ยท Tests: Everolimus, Trametinib The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201) NCT06118723n/a8 sites๐Ÿ“ San Francisco๐Ÿ“ Boston๐Ÿ“ Leuven Jasper Gerritsen ยท Tests: Supramaximal resection, Maximal safe resection ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas NCT06838676Phase 220 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Miami Nationwide Children's Hospital ยท Tests: ACT001 Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection NCT06018363Phase 1, Phase 21 site๐Ÿ“ Suzhou Dushu Lake Hospital Affiliated to Soochow University ยท Tests: Allogenic B7-H3 CAR-ฮณฮดT cell(QH104) Serial Advanced Magnetic Resonance Imaging Scan for Guidance of Personalized Adaptive Radiotherapy for High Grade Glioma NCT04771806n/a1 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Magnetic Resonance Imaging, Neurocognitive Assessment, Quality-of-Life Assessment, Questionnaire Administration Clinical Study of Carbon Ion Radiotherapy for High-grade Glioma NCT06831773NA1 site๐Ÿ“ Wuwei Gansu Wuwei Tumor Hospital ยท Tests: Carbon ion combined with photon radiotherapy Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) NCT07210632EARLY Phase 11 site๐Ÿ“ Nashville Eben Rosenthal ยท Tests: Nivolumab, Nivolumab-IRDye800 MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma NCT03896568Phase 11 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Oncolytic Adenovirus Ad5-DNX-2401, Therapeutic Conventional Surgery Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant NCT05843253Phase 220 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Ribociclib, Everolimus, Temozolomide (TMZ)
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