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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Grade 1 Glioma

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations NCT05503797Phase 270 sites๐Ÿ“ Beverly Hills๐Ÿ“ San Francisco๐Ÿ“ Westwood, Los Angeles Fore Biotherapeutics ยท Tests: Plixorafenib Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 NCT06126744Phase 12 sites๐Ÿ“ New York๐Ÿ“ Durham Duke University ยท Tests: MVR-C5252 A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925Phase 13 sites๐Ÿ“ Tampa๐Ÿ“ Chicago๐Ÿ“ New York Tetragon Biosciences Ltd ยท Tests: GLIX1 A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma NCT04166409Phase 3132 sites๐Ÿ“ Birmingham๐Ÿ“ Mesa๐Ÿ“ Phoenix National Cancer Institute (NCI) ยท Tests: Biospecimen Collection, Carboplatin, Echocardiography Test, Magnetic Resonance Imaging, Questionnaire Administration Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma NCT06410248Phase 11 site๐Ÿ“ Chicago Northwestern University ยท Tests: Biospecimen Collection, Magnetic Resonance Imaging, Questionnaire Administration, Resection, Temozolomide Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion NCT06333899EARLY Phase 118 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2, Lorlatinib post Radiation Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188Phase 1, Phase 21 site๐Ÿ“ Bethesda National Institute of Neurological Disorders and Stroke (NIโ€ฆ ยท Tests: LMP744, Conventional Surgery or Biopsy Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy NCT05180825Phase 225 sites๐Ÿ“ Amiens๐Ÿ“ Angers๐Ÿ“ Besanรงon University Hospital, Strasbourg, France ยท Tests: Trametinib, Vinblastine Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rฮฑ2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDGโ€ฆ SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance) NCT05303519Phase 361 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ Phoenix Nuvation Bio Inc. ยท Tests: safusidenib, Placebo Intracranial Genetically Modified Immune Cells (TGFฮฒR2KO/IL13Rฮฑ2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma NCT06815029Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Echocardiography, Fludeoxyglucose F-18, Intracranial โ€ฆ Window of Opportunity Study of DSP-0390 in Gliomas NCT06636162EARLY Phase 11 site๐Ÿ“ St Louis Washington University School of Medicine ยท Tests: DSP-0390 Sitagliptin in Recurrent/Progressive Grade 4 Glioma NCT07541781Phase 11 site๐Ÿ“ Iowa City Kailin Yang, MD, PhD ยท Tests: Sitagliptin, Bevacizumab Preoperative Proton Irradiation for High-grade Brain Gliomas. NCT07710040Phase 11 site๐Ÿ“ Obninsk National Medical Research Radiological Centre of the Ministโ€ฆ ยท Tests: Preoperative irradiation A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases NCT07268053EARLY Phase 11 site๐Ÿ“ Phoenix Nader Sanai ยท Tests: Risvutatug rezetecan Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors NCT07243470Phase 1, Phase 212 sites๐Ÿ“ Angers๐Ÿ“ Angers๐Ÿ“ Bordeaux Centre Leon Berard ยท Tests: Tarlatamab, Temozolomide (TMZ) A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. NCT07017816EARLY Phase 11 site๐Ÿ“ Washington D.C. Children's National Research Institute ยท Tests: SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy NCT05789394Phase 11 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Allogeneic Adipose-derived Mesenchymal Stem Cells, Biospecimen Collection, Craniotomy, Magnetic Resonance Imaging, Ommaโ€ฆ Study of Letrozole in Recurrent Gliomas NCT03122197EARLY Phase 11 site๐Ÿ“ Cincinnati University of Cincinnati ยท Tests: Letrozole Oral Tablet, Temozolomide Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease NCT07703436Phase 212 sites๐Ÿ“ Los Angeles๐Ÿ“ San Francisco๐Ÿ“ New Haven Nuvation Bio Inc. ยท Tests: Safusidenib SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma NCT04923126Phase 1, Phase 21 site๐Ÿ“ Memphis St. Jude Children's Research Hospital ยท Tests: Mirdametinib Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma NCT07061626Phase 11 site๐Ÿ“ Chicago Cerenome ยท Tests: Rhenium-186 Nanoliposome Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells NCT04254419Phase 11 site๐Ÿ“ Columbus Nationwide Children's Hospital ยท Tests: NK cells Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma NCT07551336Phase 11 site๐Ÿ“ Shenzhen Beijing Biotech ยท Tests: Dual-target CAR-NK cells, Cyclophosphamide, Intracranial catheter/reservoir for locoregional delivery, Fludarabine 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours NCT06630260Phase 1, Phase 23 sites๐Ÿ“ Cambridge๐Ÿ“ Sutton๐Ÿ“ Sutton Institute of Cancer Research, United Kingdom ยท Tests: Avutometinib, Defactinib, Temozolomide A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions NCT06072586EARLY Phase 12 sites๐Ÿ“ Chandler๐Ÿ“ Phoenix St. Joseph's Hospital and Medical Center, Phoenix ยท Tests: BDTX-1535, BDTX-1535 combined with radiation therapy, BDTX-1535 combined with temozolomide and radiation therapy A Study of 177Lu-PSMA-617 in People With Gliomas NCT07223034Phase 17 sites๐Ÿ“ Basking Ridge๐Ÿ“ Middletown๐Ÿ“ Montvale Memorial Sloan Kettering Cancer Center ยท Tests: Temozolomide, 177Lu-PSMA-617, 68Ga-PSMA-PET scan/ MRI, Quality of Life Questionnaires ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors NCT04732065Phase 17 sites๐Ÿ“ San Francisco๐Ÿ“ Washington D.C.๐Ÿ“ Atlanta Sabine Mueller, MD, PhD ยท Tests: ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS) Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors NCT07410494Phase 1, Phase 21 site๐Ÿ“ Beijing Essen Biotech ยท Tests: EB-SELECT Single-Target CAR-NK Cells, Dual-Target Antigen-Selected CAR-NK A Study of Zedoresertib (Debio 0123) in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Zedoresertib (Debio 0123) in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma NCT05765812Phase 1, Phase 216 sites๐Ÿ“ Chicago๐Ÿ“ New York๐Ÿ“ New York Debiopharm International SA ยท Tests: Zedoresertib, Temozolomide, Radiotherapy
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