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24 recruiting trials

for Hemophagocytic Lymphohistiocytoses

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford NCT01793168n/a1 site๐Ÿ“ Sioux Falls Sanford Health Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH) NCT05416307Phase 2, Phase 342 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ Los Angeles Electra Therapeutics Inc. ยท Tests: ELA026 Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT NCT01962415Phase 21 site๐Ÿ“ Pittsburgh Paul Szabolcs ยท Tests: Hydroxyurea, Alemtuzumab, Fludarabine, Melphalan, Thiotepa Establishing a National Egyptian HLH Registry (NEHR) NCT07800234n/a2 sites๐Ÿ“ Cairo๐Ÿ“ Cairo Ain Shams University CytOSorb TreatMent Of Critically Ill PatientS Registry NCT05146336n/a28 sites๐Ÿ“ Klagenfurt๐Ÿ“ Vienna๐Ÿ“ Aachen CytoSorbents, Inc ยท Tests: CytoSorb Letermovir Prophylaxis in Children With EBV-Positive T/NK-Cell Lymphoproliferative Disease and Refractory/Relapsed EBV-Associated Hemophagocytic Lymphohistiocytosis NCT07488728NA1 site๐Ÿ“ Beijing Beijing Children's Hospital ยท Tests: Letermovir Ruxolitinib for Immune Effector Cell Associated Hemophagocytic Lymphohistiocytosis-like Syndrome (RISE) NCT07424222Phase 11 site๐Ÿ“ Baltimore Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ยท Tests: Ruxolitinib Ruxolitinib With De-Intensified HLH-94 for the Treatment of Hemophagocytic Lymphohistiocytosis (HLH) NCT06160791Phase 24 sites๐Ÿ“ Irvine๐Ÿ“ Sacramento๐Ÿ“ San Diego Jerry Lee, MD, MSc, MPhil ยท Tests: Ruxolitinib, Etoposide, Dexamethasone, Non-interventional Imaging, Research Biopsy Prospective Cohort for Adult Hemophagocytosis NCT03117010n/a1 site๐Ÿ“ Seoul Samsung Medical Center ยท Tests: Steroids, Etoposide Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC NCT04528355n/a1 site๐Ÿ“ Pittsburgh Paul Szabolcs ยท Tests: data collection Surveillance and Tracking the Outcomes of Chronic Latent EBV Infection NCT03491605n/a1 site๐Ÿ“ Wuhan Huazhong University of Science and Technology ยท Tests: peripheral EBV-DNA load Hemophagocytic Lymphohistiocytosis After Allogeneic Stem Cell Transplantation NCT07905066n/a1 site๐Ÿ“ Beijing Peking University People's Hospital Clinical Study of EBV-TCR-T Cells for EBV-associated Hemophagocytic Lymphohistiocytosis or EBV Infection NCT06135922Phase 11 site๐Ÿ“ Beijing Chinese PLA General Hospital ยท Tests: EBV-TCR-T cells Assessing the Presence of CT-DNA in Lymphoma Associated HLH NCT05702502n/a1 site๐Ÿ“ Nottingham Nottingham University Hospitals NHS Trust Zanubrutinib Combined With Rituximab in the Treatment of Secondary HLH in B-cell Lymphoma NCT07270835Phase 41 site๐Ÿ“ Suzhou The First Affiliated Hospital of Soochow University ยท Tests: Rituximab, Zanubrutinib A Phase III Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of Plonmarlimab in Subjects With Relapsed/Refractory Rheumatic and Immunologic Disease-associated Haemophagocytic Lymphohistiocytosis (Also Known as Macrophage Activation Syndrome [MAS]) NCT07208058Phase 318 sites๐Ÿ“ Beijing๐Ÿ“ Beijing๐Ÿ“ Beijing TJ Biopharma Co., Ltd. ยท Tests: Plonmarlimab Describing Treatment Outcomes and Responses in Lymphoma-associated Hemophagocytic Lymphohistiocytosis NCT05898477n/a1 site๐Ÿ“ Birmingham University of Alabama at Birmingham A Randomized Controlled Study of High-dose Cyclophosphamide Induction Therapy in Adult Patients With HLH NCT05936086NA1 site๐Ÿ“ Chongqing shifeng Lou ยท Tests: Cytoxan, Etoposide, Dexamethasone, Cyclosporine (CSA) Ruxolitinib as First Line Treatment in Primary Haemophagocytic Lymphohistiocytosis (R-HLH) NCT05762640Phase 21 site๐Ÿ“ Paris Assistance Publique - Hรดpitaux de Paris ยท Tests: Ruxolitinib Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH) NCT07525466Phase 1, Phase 21 site๐Ÿ“ Beijing Beijing Tongren Hospital ยท Tests: Mitoxantrone liposome, Etoposide, Pegaspargase (PEG) Asparaginase, methylprednisolone, golidocitinib INTO-HLH: A Disease Registry for Patients With Hemophagocytic Lymphohistiocytosis (HLH) NCT05277272n/a1 site๐Ÿ“ Cincinnati Children's Hospital Medical Center, Cincinnati Prospective Single-Arm Clinical Trial of GO Regimen for HLH. NCT07339345Phase 2, Phase 31 site๐Ÿ“ Beijing Beijing Friendship Hospital ยท Tests: Golidocitinib Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study NCT06339177n/a2 sites๐Ÿ“ Bethesda๐Ÿ“ Pittsburgh National Institute of Allergy and Infectious Diseases (NIAIโ€ฆ Prospective Validation of the OHI Index NCT05882175n/a2 sites๐Ÿ“ Kfar Saba๐Ÿ“ Petah Tikva Meir Medical Center
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