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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for High Grade Glioma

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion NCT04655404EARLY Phase 121 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Larotrectinib, Larotrectinib surgical rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG NCT04943848Phase 13 sites๐Ÿ“ Orange๐Ÿ“ Chicago๐Ÿ“ Boston Ann & Robert H Lurie Children's Hospital of Chicago ยท Tests: rHSC-DIPGVax, Balstilimab, Zalifrelimab A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations NCT05503797Phase 270 sites๐Ÿ“ Beverly Hills๐Ÿ“ San Francisco๐Ÿ“ Westwood, Los Angeles Fore Biotherapeutics ยท Tests: Plixorafenib Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors NCT00870129NA1 site๐Ÿ“ New York Memorial Sloan Kettering Cancer Center ยท Tests: MRI and advanced MRI sequences Evaluation of Clinical Efficacy and Safety of Specific Mode Electroacupuncture Stimulation for Paclitaxel Across BBB Delivery in Patients With Postoperative Recurrence of Malignant Glioma: A Single-arm Trial NCT06818331Phase 21 site๐Ÿ“ China The Third Affiliated hospital of Zhejiang Chinese Medical Uโ€ฆ ยท Tests: SMES+PTX, Paclitaxel, Specific mode electroacupuncture stimulation CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults NCT06305910Phase 11 site๐Ÿ“ Minneapolis OX2 Therapeutics ยท Tests: Treatment with CD200AR-L Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression NCT06975332NA2 sites๐Ÿ“ Warsaw๐Ÿ“ Warsaw Medical University of Warsaw ยท Tests: Local, targeted therapy with alpha emitter [225Ac]Ac-DOTA-SP (TAT) Bevacizumab Neoadjuvant Therapy for New High-grade Gliomas in the Brain NCT06747728NA1 site๐Ÿ“ Zhengzhou The First Affiliated Hospital of Zhengzhou University ยท Tests: Bevacizumab Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma NCT04547777Phase 11 site๐Ÿ“ Durham Darell Bigner ยท Tests: D2C7-IT, 2141-V11 [177Lu]Lu-DOTA-EB-RGD2 Therapy in Patients With Recurrent High-grade Glioma NCT07655869EARLY Phase 12 sites๐Ÿ“ Beijing๐Ÿ“ Beijing Beijing Tiantan Hospital ยท Tests: [177Lu]Lu-DOTA-EB-RGD2 Study in Children and Adolescents of 177Lu-DOTATATE (Lutatheraยฎ) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). NCT06607692Phase 1, Phase 21 site๐Ÿ“ Boadilla del Monte Fundaciรณn de investigaciรณn HM ยท Tests: Olaparib; 177Lu-DOTATATE Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 NCT06126744Phase 12 sites๐Ÿ“ New York๐Ÿ“ Durham Duke University ยท Tests: MVR-C5252 A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925Phase 13 sites๐Ÿ“ Tampa๐Ÿ“ Chicago๐Ÿ“ New York Tetragon Biosciences Ltd ยท Tests: GLIX1 A Clinical Trial Evaluating the Tolerability, Safety, and Preliminary Efficacy of NRG-103 Injection in Patients With Recurrent or Progressive High-grade Glioma NCT07710690Phase 13 sites๐Ÿ“ Shanghai๐Ÿ“ Wuhan๐Ÿ“ Xi'an Neuregen Therapeutics Co., Ltd. ยท Tests: NRG-103 Metabolomics and Transcriptomics of Low- and High-Grade Gliomas NCT07832734n/a1 site๐Ÿ“ Milan I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion NCT06333899EARLY Phase 118 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2, Lorlatinib post Radiation C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B) NCT04099797Phase 11 site๐Ÿ“ Houston Baylor College of Medicine ยท Tests: C7R-GD2.CART cells (IV and ICV infusion), C7R-GD2.CART cells (IV and ICV infusion) 000860: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations NCT05588141Phase 1, Phase 22 sites๐Ÿ“ Jacksonville๐Ÿ“ Bethesda National Cancer Institute (NCI) ยท Tests: Zotiraciclib Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients NCT03849430n/a1 site๐Ÿ“ Leuven Universitaire Ziekenhuizen KU Leuven Non-invasive Glioma Characterization Through Molecular Imaging NCT03684109NA1 site๐Ÿ“ Miami University of Miami ยท Tests: 3T MRI Scanner A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma NCT07306299Phase 11 site๐Ÿ“ Hangzhou Second Affiliated Hospital, Zhejiang University, School of โ€ฆ ยท Tests: Glioma-related multi-target mRNA vaccines Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188Phase 1, Phase 21 site๐Ÿ“ Bethesda National Institute of Neurological Disorders and Stroke (NIโ€ฆ ยท Tests: LMP744, Conventional Surgery or Biopsy Chronic CED of TPT for Recurrent Malignant Glioma NCT06666712Phase 11 site๐Ÿ“ New York Jeffrey N. Bruce ยท Tests: Topotecan Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors NCT04299191Phase 1, Phase 23 sites๐Ÿ“ Little Rock๐Ÿ“ Miami๐Ÿ“ Edison Laminar Pharmaceuticals ยท Tests: LAM561 Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases NCT06888817Phase 36 sites๐Ÿ“ Amsterdam๐Ÿ“ Amsterdam๐Ÿ“ Leiden The Netherlands Cancer Institute ยท Tests: Bevacizumab, Dexamethasone Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rฮฑ2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDGโ€ฆ Dabrafenib and/or Trametinib Rollover Study NCT03340506Phase 438 sites๐Ÿ“ Scottsdale๐Ÿ“ Bethesda๐Ÿ“ Columbus Novartis Pharmaceuticals ยท Tests: dabrafenib, trametinib Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) NCT04485559Phase 117 sites๐Ÿ“ Birmingham๐Ÿ“ Los Angeles๐Ÿ“ San Diego University of California, San Francisco ยท Tests: Everolimus, Trametinib The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201) NCT06118723n/a8 sites๐Ÿ“ San Francisco๐Ÿ“ Boston๐Ÿ“ Leuven Jasper Gerritsen ยท Tests: Supramaximal resection, Maximal safe resection ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas NCT06838676Phase 220 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Miami Nationwide Children's Hospital ยท Tests: ACT001
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