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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Hormone Receptor-positive Metastatic Breast Cancer

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment. NCT07062965Phase 3433 sites๐Ÿ“ Anchorage๐Ÿ“ Chandler๐Ÿ“ Gilbert Pfizer ยท Tests: PF-07248144, Fulvestrant, Everolimus, Exemestane Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors NCT07288359Phase 1, Phase 216 sites๐Ÿ“ Atlanta๐Ÿ“ Nashville๐Ÿ“ San Antonio Novartis Pharmaceuticals ยท Tests: GVV858, Fulvestrant, Letrozole DiviTumยฎTKa: A Biomarker Assay for Efficacy in HR+ Breast Cancer Patients NCT06388122n/a1 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Biospecimen Collection SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain Metastases NCT04923542Phase 1, Phase 22 sites๐Ÿ“ Tampa๐Ÿ“ Columbus H. Lee Moffitt Cancer Center and Research Institute ยท Tests: Stereotactic Radiosurgery (SRS), Abemaciclib, Endocrine therapy FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer NCT05304962Phase 18 sites๐Ÿ“ La Jolla๐Ÿ“ Los Angeles๐Ÿ“ Port Saint Lucie Regor Pharmaceuticals Inc. ยท Tests: RGT-419B, RGT-419B in combination with hormonal therapy Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer NCT06982521Phase 3243 sites๐Ÿ“ Gilbert๐Ÿ“ Beverly Hills๐Ÿ“ Duarte Relay Therapeutics, Inc. ยท Tests: Zovegalisib, Capivasertib, Fulvestrant A Vaccine (STEMVAC) With Standard Endocrine-Based Therapy or Chemotherapy for the Treatment of Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer NCT07112053Phase 21 site๐Ÿ“ Seattle University of Washington ยท Tests: CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine, Capecitabine, Computed Tomography, Cyclin-Dependent Kinase 4โ€ฆ Entinostat Plus Pyrotinib and Endocrine Therapy in Advanced Triple-Positive Breast Cancer After Trastuzumab Failure NCT07708194Phase 1, Phase 21 site๐Ÿ“ Tianjin Tianjin Medical University Cancer Institute and Hospital ยท Tests: entinostat, Pyrotinib, endocrine therapy A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer NCT06678269Phase 17 sites๐Ÿ“ Basking Ridge๐Ÿ“ Middletown๐Ÿ“ Montvale Memorial Sloan Kettering Cancer Center ยท Tests: Abemaciclib, Radiation Therapy Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer NCT05524584Phase 21 site๐Ÿ“ Orange University of California, Irvine ยท Tests: Fulvestrant, Anastrozole, Abemaciclib PRE-ISPY Phase I/II Oncology Platform Program NCT05868226Phase 1, Phase 210 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ Aurora QuantumLeap Healthcare Collaborative ยท Tests: ALX148, Fam-Trastuzumab Deruxtecan-Nxki, Zanidatamab, Tucatinib, TTX-MC138 Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer NCT07558733Phase 1, Phase 27 sites๐Ÿ“ Los Angeles๐Ÿ“ Lone Tree๐Ÿ“ Springfield Faeth Therapeutics ยท Tests: Serabelisib, Sapanisertib, Fulvestrant A Study of Patritumab Deruxtecan (HER3-DXd) in Combination With Trastuzumab Deruxtecan (T-DXd) in Participants With HR-Positive, HER2-Low or HER2-Ultralow Unresectable or Metastatic Breast Cancer NCT07701941Phase 1, Phase 272 sites๐Ÿ“ Los Angeles๐Ÿ“ Stanford๐Ÿ“ Aurora Daiichi Sankyo ยท Tests: Patritumab deruxtecan, Trastuzumab deruxtecan Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001) NCT05579366Phase 1, Phase 266 sites๐Ÿ“ Phoenix๐Ÿ“ Tucson๐Ÿ“ Los Angeles Genmab ยท Tests: Rina-S, Carboplatin, Bevacizumab, Pembrolizumab, Erythromycin Artificial Intelligence and Machine Learning to Guide CDK4/6 Inhibitor Rechallenge in Breast Cancer. NCT07227233Phase 21 site๐Ÿ“ La Jolla University of California, San Diego ยท Tests: A CDK4/6 inhibitor different from the first that the participant had received, plus fulvestrant., Treatment of physiciaโ€ฆ ARX788 for Treating Patients With HER2-low Locally Advanced Unresectable or Metastatic Breast Cancer NCT06224673Phase 21 site๐Ÿ“ San Francisco Laura Huppert, MD, BA ยท Tests: ARX788, Computed Tomography (CT), Biospecimen Collection, Amiloride Combination of Abemaciclib and Endocrine Therapy in Hormone Receptor Positive HER2 Negative Locally Advanced or Metastatic Breast Cancer With Focus on Digital Side Effect Management NCT05362760Phase 454 sites๐Ÿ“ Aalen๐Ÿ“ Amberg๐Ÿ“ Aschaffenburg Prof. Wolfgang Janni ยท Tests: Abemaciclib + Aromatase Inhibitor, Abemaciclib + Fulvestrant A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer NCT07205822Phase 340 sites๐Ÿ“ Largo๐Ÿ“ Fort Wayne๐Ÿ“ Omaha AstraZeneca ยท Tests: Dato-DXd Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies NCT07340541Phase 26 sites๐Ÿ“ New Haven๐Ÿ“ Baltimore๐Ÿ“ Rochester UNC Lineberger Comprehensive Cancer Center ยท Tests: SERD* + abemaciclib, SERD* + everolimus, SERD* + everolimus or capecitabine, SOC, Antiandrogen Sac-TMT Plus KL-A167 in PD-L1+, HR+/HER2- Metastatic Breast Cancer After CDK4/6 Inhibitors NCT07258108Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Lucanisatuzumab plus tagolimumab Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer NCT07137416Phase 12 sites๐Ÿ“ Boston๐Ÿ“ St Louis National Cancer Institute (NCI) ยท Tests: Biopsy Procedure, Biospecimen Collection, Echocardiography Test, Multigated Acquisition Scan, Pidnarulex A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors NCT07020117Phase 114 sites๐Ÿ“ Duarte๐Ÿ“ Irvine๐Ÿ“ Miami Aktis Oncology, Inc. ยท Tests: [225Ac]Ac-AKY-1189 (therapeutic), [64Cu]Cu-AKY-1189 (imaging) AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors NCT07454642Phase 17 sites๐Ÿ“ Scottsdale๐Ÿ“ Sarasota๐Ÿ“ Chicago Avacta Life Sciences Ltd ยท Tests: AVA6103 Study of XB010 in Subjects With Solid Tumors NCT06545331Phase 120 sites๐Ÿ“ Irvine๐Ÿ“ Los Angeles๐Ÿ“ Washington D.C. Exelixis ยท Tests: XB010, Pembrolizumab Anlotinib-based Combination Therapy in Patients with Hormone Receptor-positive๏ผˆHR+๏ผ‰ Metastatic Breast Cancer(MBC) . NCT06734533n/a1 site๐Ÿ“ Changsha Hunan Cancer Hospital ยท Tests: Anlotinib+eribulin/nab-paclitaxel/etoposide/capecitabine/pembrolizumab/ sintilimab/ fulvestrant, etc Real-World Study of Post-Resistance Treatment Strategies in Advanced Breast Cancer Following CDK4/6i, PIK3CA Inhibitors, or T-DXd NCT07073755n/a1 site๐Ÿ“ Changsha Hunan Cancer Hospital A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer NCT06369285Phase 253 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ Beverly Hills Puma Biotechnology, Inc. ยท Tests: Alisertib, Endocrine therapy A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy NCT05646862Phase 3210 sites๐Ÿ“ Greenbrae๐Ÿ“ Los Alamitos๐Ÿ“ Los Angeles Hoffmann-La Roche ยท Tests: Inavolisib, Fulvestrant, Alpelisib, Bupropion, Omeprazole Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer NCT06525766Phase 21 site๐Ÿ“ Scottsdale Mayo Clinic ยท Tests: Biospecimen Collection, Bone Scan, Capecitabine, Computed Tomography, Magnetic Resonance Imaging Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer. NCT04305834Phase 26 sites๐Ÿ“ Duarte๐Ÿ“ Irvine๐Ÿ“ Long Beach City of Hope Medical Center ยท Tests: Abemaciclib, Questionnaire Administration
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