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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for LOCALLY ADVANCED RECTAL CANCER

SCRT VS LCRT Followed by PD-L1 Inhibitor Plus CAPEOX as TNT in Patients With LARC NCT07284992Phase 21 site📍 Jinan Shandong Provincial Hospital · Tests: short-term radiotherapy combined with Adebrelimab and capox, long-term radiotherapy combined with Adebrelimab and capox A Study of Tucatinib and Trastuzumab in People With Rectal Cancer NCT05672524Phase 27 sites📍 Basking Ridge📍 Middletown📍 Montvale Memorial Sloan Kettering Cancer Center · Tests: Trastuzumab, Tucatinib Organ Preservation in Locally Advanced Rectal Cancer NCT03064646NA1 site📍 Elche Fundación para el Fomento de la Investigación Sanitaria y B… · Tests: Organ Preservation Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer. NCT06940388Phase 22 sites📍 Mainz📍 Petah Tikva brenner baruch · Tests: Tislelizumab, Total neoadjuvant therapy (TNT) MR-guided Adaptive Radiotherapy Combined With PD-1 Antibody and CAPOX for Locally Advanced Rectal Cancer NCT06840665Phase 21 site📍 Shanghai Fudan University · Tests: PD-1 antibody, Oxaliplatin, Capecitabine Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoadjuvant Treatment of Patients With Locally Advanced HER2-positive Rectal Cancer NCT07108127Phase 21 site📍 Beijing Peking Union Medical College Hospital · Tests: Trastuzumab biosimilars and pertuzumab biosimilars plus XELOX Comparing Efficacy and Safety of Enlituo® Versus Erbitux® Plus FOLFOX in Locally Advanced/Metastatic Colorectal Cancer With RAS/BRAF Wild-type and MSS/pMMR Status. NCT07595276Phase 31 site📍 Guangzhou Taizhou Mabtech Pharmaceutical Co.,Ltd · Tests: Enlituo®, Erbitux® Application of PET/MRI in the Evaluation of the Efficacy of Neoadjuvant Therapy for Locally Advanced Rectal Cancer NCT06653452NA1 site📍 Beijing Peking Union Medical College Hospital · Tests: 18F-FDG PET/CT and PET/MR scan, 68Ga-FAPI-04 PET/CT and PET/MR scan To Explore the Efficacy of Sintilimab Combined With Bevacizumab in Rectal Cancer NCT06808412Phase 21 site📍 Xi'an xiaohua li · Tests: sintilimab combined with bevacizumab and XELOX UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer NCT05148767Phase 41 site📍 Hangzhou Zhejiang Cancer Hospital · Tests: Neoadjuvant chemoradiotherapy based on irinotecan Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer NCT07528209Phase 31 site📍 Guangzhou Sun Yat-sen University · Tests: Pucotenlimab combine with CAPOX, CAPOX Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy NCT05965531Phase 21 site📍 Guangzhou Sun Yat-sen University · Tests: Trifluridine/Tipiracil, intensity-modulated radiotherapy Short-course Radiotherapy Followed by Sequential Chemotherapy With or Without PD-1 Monoclonal Antibody and Bevacizumab as Total Neoadjuvant Therapy in pMMR/MSS Locally Advanced Rectal Cancer （SPARK） NCT07005570Phase 21 site📍 Guangzhou Dechang Diao · Tests: Short-course radiotherapy followed by sequential chemotherapy combined with PD-1 monoclonal antibody and bevacizumab, S… A Dose-Expansion Trial of Intravenous HNF4α srRNA for Unresectable or Metastatic Colorectal Cancer NCT07050394EARLY Phase 11 site📍 Shanghai Shanghai Changzheng Hospital · Tests: CD-GA-102 Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I) NCT06923345Phase 21 site📍 Guangzhou Sixth Affiliated Hospital, Sun Yat-sen University · Tests: Reduced CTV, Conventional CTV A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors NCT06440005Phase 17 sites📍 Los Angeles📍 Sarasota📍 St Louis Angiex, Inc. · Tests: AGX101 A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy NCT06362369Phase 1, Phase 25 sites📍 Aurora📍 Lake Mary📍 Lebanon 7 Hills Pharma, LLC · Tests: Alintegimod, Ipilimumab, Nivolumab A Study of SI-B003, BL-B01D1+SI-B003 and BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Esophageal Cancer, Gastric Cancer, Colorectal Cancer and Other Gastrointestinal Tumors NCT06008054Phase 21 site📍 Beijing Sichuan Baili Pharmaceutical Co., Ltd. · Tests: SI-B003, BL-B01D1, PD-1 Monoclonal Antibody Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer NCT06903858Phase 21 site📍 Guangzhou Sun Yat-sen University · Tests: Toripalimab plus celecoxib, Non-operative management, Curative-intent surgery Short-Course Radiotherapy Followed by Immunotherapy Combined With Chemotherapy for Microsatellite Stable Locally Advanced Rectal Cancer: A Prospective, Randomized, Controlled Phase II Clinical Trial NCT07594925Phase 21 site📍 Tianjin Tianjin Medical University Cancer Institute and Hospital · Tests: Sintilimab, Chemotherapy Drugs, radiotherapy Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal Cancer NCT07686640Phase 31 site📍 Jinan Shandong Cancer Hospital and Institute · Tests: Short-Course Radiotherapy, Consolidation treatment (With ICIs), Consolidation treatment (Without ICIs) SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer NCT05412082Phase 11 site📍 Miami University of Miami · Tests: Intensity-modulated radiation therapy, 5-fluorouracil, Leucovorin, Oxaliplatin, Capecitabine A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Gastrointestinal Tumor and Other Solid Tumor NCT05262491Phase 16 sites📍 Beijing📍 Nanchang📍 Jinan Sichuan Baili Pharmaceutical Co., Ltd. · Tests: BL-B01D1 EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors NCT07410676Phase 1, Phase 21 site📍 Beijing Essen Biotech · Tests: EBNK-001 + IL-15 + Pembrolizumab GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors NCT06265025Phase 1, Phase 24 sites📍 Goyang-si📍 Seoul📍 Seoul GeneMedicine Co., Ltd. · Tests: GM103 (Part A), GM103 (Part B), GM103 and Pembrolizumab (Part C) Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT) NCT06770270Phase 21 site📍 Hangzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Pucotenlimab THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI Guided Radiotherapy NCT04815694NA1 site📍 Roma Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Tests: RT Dose escalation in LARC patients with an Early Regression Index > 13.1 at second week on nCRT Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients NCT06812728Phase 21 site📍 Shibīn al Kawm Menoufia University · Tests: mFOLFIRINOX, mFolfox6 Study of IBI3028 in Participants With Locally Advanced, Unresectable, or Metastatic Solid Tumors NCT07589205Phase 11 site📍 Tianjin Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. · Tests: Drug: IBI3028 Galenos 2 Immunonutrition in Head and Neck, Lung, and Rectal Cancer Patients NCT07514754NA1 site📍 Candiolo Fondazione del Piemonte per l'Oncologia · Tests: Galenic Immunonutrition Formula
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