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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

Know your stage or your test results (such as EGFR, HER2 or BRCA)? Match trials to your own profile - nothing you type is saved.

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30 recruiting trials

for Leptomeningeal Metastasis

A Phase IIa Study to Evaluate NBQ72S NCT06810804Phase 21 site📍 Beijing Nantong Bencao Quadriga Medical Technology Co. Ltd. · Tests: NBQ72S Exploration of the Application of Methotrexate-loaded Drug Vesicles in Intrathecal Injection for Meningeal Metastasis of Lung Cancer NCT07559097Phase 1, Phase 21 site📍 Zhengzhou Henan Cancer Hospital · Tests: Methotrexate-loaded vesicles Furmonertinib Combined With Intrathecal Chemotherapy and Stereotactic Radiotherapy (SRT) for EGFR-Mutated NSCLC Patients With Brain Parenchymal and Leptomeningeal Metastases NCT07304739Phase 23 sites📍 Cangzhou📍 Tianjin📍 Tianjin Tianjin Medical University Cancer Institute and Hospital · Tests: Furmonertinib, Intrathecal chemotherapy, Stereotactic radiotherapy Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis NCT06643000NA2 sites📍 Zhengzhou📍 Zhengzhou Henan Cancer Hospital · Tests: furmonertinib Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases NCT07098806Phase 1, Phase 21 site📍 San Antonio Cerenome · Tests: 186RNL Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC NCT05805631Phase 21 site📍 Taipei Taipei Veterans General Hospital, Taiwan · Tests: Pemetrexed Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC NCT06663306Phase 11 site📍 Shanghai Shanghai Chest Hospital · Tests: Pemetrexed, Bevacizumab Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial NCT06500481Phase 358 sites📍 Phoenix📍 Little Rock📍 Encinitas NRG Oncology · Tests: Biospecimen Collection, Computed Tomography, Involved-Field Radiation Therapy, Lumbar Puncture, Magnetic Resonance Imag… Dual-targeting VEGFR1 and PD-L1 CAR-T for Pleural, Peritoneal, or Leptomeningeal Metastases NCT05477927Phase 11 site📍 Chengdu Sichuan University · Tests: Dual-targeting VEGFR1/PD-L1 CAR-T cells Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology NCT04988009n/a1 site📍 Houston M.D. Anderson Cancer Center · Tests: Electronic Health Record Review, Survey Administration Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis NCT06933199NA4 sites📍 Ostrava📍 Brno📍 Hradec Králové University Hospital Ostrava · Tests: Neoadjuvant Stereotactic Radiotherapy (NaSRT), Postoperative Stereotactic Radiotherapy (SRT) Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II Study NCT07398599NA1 site📍 Nanchang Second Affiliated Hospital of Nanchang University · Tests: a combined regimen consisting of double-dose third-generation EGFR-TKI, bevacizumab, and intrathecal chemotherapy in pa… Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26) NCT05112549Phase 19 sites📍 Bonn📍 Freiburg im Breisgau📍 Heidelberg University Hospital Tuebingen · Tests: Nivolumab [Opdivo] BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies NCT07789912NA1 site📍 Miami University of Miami · Tests: Radiation Treatments Using Brain- Avoidant Proton Craniospinal Irradiation (BRAVO- pCSI) Evaluate the Safety, Tolerability, Biodistribution Characteristics and Preliminary Efficacy of BioTTT001 NCT07264569Phase 1, Phase 21 site📍 Zhengzhou Henan Cancer Hospital · Tests: BioTTT001 injection Amivantamab Combined With Intrathecal Pemetrexed for LM From EGFR-Mutated Lung Adenocarcinoma NCT07744529Phase 1, Phase 21 site📍 Hangzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Amivantamab+ systemic/ intrathecal Pemetrexed Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer NCT06431685Phase 11 site📍 Chengdu Sichuan University · Tests: Whole Brain Low Dose Radiotherapy, Pemetrexed, Sintilimab, Chemotherapy CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease NCT05257967NA1 site📍 Vancouver British Columbia Cancer Agency · Tests: Lumbar puncture and Phlebotomy Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. NCT06296745Phase 21 site📍 Huizhou Guangzhou Medical University · Tests: Pemetrexed Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases NCT06440954Phase 21 site📍 Changsha Hunan Province Tumor Hospital · Tests: Intrathecal pemetrexed Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer NCT06058988Phase 21 site📍 New York Memorial Sloan Kettering Cancer Center · Tests: Trastuzumab deruxtecan Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases NCT07092202Phase 41 site📍 Wuhan Union Hospital, Tongji Medical College, Huazhong University… · Tests: Firmonertinib, Intrathecal injection of pemetrexed Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir NCT06399926n/a1 site📍 Changsha Xiangya Hospital of Central South University · Tests: Pemetrexed injection, Pemetrexed Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer NCT06304441NA1 site📍 Huizhou Guangzhou Medical University · Tests: Osimertinib, Pemetrexed ctDNA-driven Adaptive Proton Craniospinal Irradiation in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis After Resistance to Third-Generation TKIs in the Consolidation Phase NCT07751536NA3 sites📍 Hefei📍 Hefei📍 Nanjing Shuanghu Yuan · Tests: proton craniospinal irradiation, Intrathecal pemetrexed Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer NCT06462092Phase 1, Phase 21 site📍 Huizhou Guangzhou Medical University · Tests: Sacituzumab Govitecan, Pemetrexed Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study NCT06016387Phase 22 sites📍 Ottawa📍 Toronto Sunnybrook Health Sciences Centre · Tests: Tucatinib 150 MG, Trastuzumab, Capecitabine, Brain & Spinal Radiation A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China NCT06718972n/a2 sites📍 Guangzhou📍 Guangzhou Guangzhou Medical University · Tests: Not applicable- observational study Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study NCT07476781NA1 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: One time CSF and blood sample Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis NCT06230055Phase 41 site📍 Shanghai Fudan University · Tests: Ommaya reservoir, Systematic chemotherapy, Intrathecal chemotherapy
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