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Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Locally Advanced Gastroesophageal Junction Adenocarcinoma

SHR-1701 With or Without Apatinib in Combination With Chemotherapy as Neoadjuvant Therapy for Gastric Cancer NCT07464756Phase 21 site๐Ÿ“ Nanjing The First Affiliated Hospital with Nanjing Medical Universiโ€ฆ ยท Tests: SHR-1701, apatinib, S-1 & Oxaliplatin A Study to Observe the Safety of VYLOY (Zolbetuximab) in People in South Korea With Gastric or Gastroesophageal Junction Cancer. NCT06902545n/a15 sites๐Ÿ“ Goyang-si๐Ÿ“ Suwon๐Ÿ“ Suwon Astellas Pharma Korea, Inc. ยท Tests: zolbetuximab A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma NCT07043400Phase 395 sites๐Ÿ“ Chandler๐Ÿ“ Los Alamitos๐Ÿ“ Colorado Springs BeOne Medicines ยท Tests: Subcutaneous Tislelizumab, Intravenous Tislelizumab, Cisplatin, Leucovorin, 5-fluorouracil (5-FU) Adebrelimab Combined With Nab-paclitaxel, Oxaliplatin and Tegafur (AOS) for Perioperative Treatment of Locally Advanced Resectable GC/GEJ NCT06808971Phase 21 site๐Ÿ“ Beijing Cancer Institute and Hospital, Chinese Academy of Medical Sโ€ฆ ยท Tests: Adebrelimab, Nab-paclitaxel, Oxaliplatin, Tegafur Gimeracil Oteracil Potassium Capsule Neoadjuvant Iparomlimab and Tuvonralimab With Nab-P-SOX in Locally Advanced Gastric or Gastroesophageal Junction Cancer NCT07867392Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: Iparomlimab and Tuvonralimab (QL1706), nab-P-SOX๏ผˆnab-paclitaxel, oxaliplatin, S-1๏ผ‰ A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma NCT07069712Phase 270 sites๐Ÿ“ Newark๐Ÿ“ Washington D.C.๐Ÿ“ Fairway AstraZeneca ยท Tests: Sonesitatug Vedotin, Rilvegostomig, Trastuzumab Deruxtecan (T-DXd), Capecitabine, 5-Fluorouracil (5-FU) Perioperative Chemotherapy Combined With Serplulimab or Placebo for pMMR Locally Advanced Gastric Adenocarcinoma (FOCUS-05) NCT05872685Phase 25 sites๐Ÿ“ Hangzhou๐Ÿ“ Hangzhou๐Ÿ“ Lishui Yu jiren ยท Tests: S1, Oxaliplatin, Serplulimab, Placebo Neoadjuvant Immunochemotherapy in Locally Advanced Esophagogastric Junction Adenocarcinoma NCT05170503Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Sintilimab Perioperative Treatment of Combined Radiotherapy With SOX, Apatinib and Camrelizumab for Oesophagogastric Cancer NCT07026149Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: Apatinib+Camrelizumab+SOX, Preoperative Radiotherapy Neoadjuvant Tislelizumab + LM-302 + S-1 or Tislelizumab + SOX for CLDN18.2-Positive Gastric/GEJ Adenocarcinoma NCT07569068Phase 21 site๐Ÿ“ Shanghai Ruijin Hospital ยท Tests: Tislelizumab, LM-302 and S-1, Tislelizumab combined with oxaliplatin and S-1 Perioperative FLOT vs Adjuvant XELOX for CA Stomach NCT05264896Phase 31 site๐Ÿ“ Hong Kong Chinese University of Hong Kong ยท Tests: 5-FU, Leucovorin, Oxaliplatin, Docetaxel, XELOX A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer NCT06901531Phase 3252 sites๐Ÿ“ Birmingham๐Ÿ“ Bakersfield๐Ÿ“ Cerritos Astellas Pharma Global Development, Inc. ยท Tests: zolbetuximab, Pembrolizumab, Capecitabine, Oxaliplatin, Folinic acid (leucovorin or local equivalent) DBC-664 in Adult Patients With Solid Tumors NCT07705035Phase 17 sites๐Ÿ“ Denver๐Ÿ“ Grand Rapids๐Ÿ“ St Louis Duboce Biopharmaceuticals, Inc. ยท Tests: DBC-664 Chemoradiotherapy and SHR-1701 in Patients With Unresectable Gastric Cancer NCT07689851Phase 23 sites๐Ÿ“ Shenzhen๐Ÿ“ Taiyuan๐Ÿ“ Beijing Cancer Institute and Hospital, Chinese Academy of Medical Sโ€ฆ ยท Tests: COPOX, Radiotherapy, SHR-1701 Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program NCT06265285Phase 21 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Home Health Encounter, Nivolumab, Patient Monitoring, Questionnaire Administration Perioperative Chemotherapy Plus Toripalimab for dMMR Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma NCT05729646Phase 28 sites๐Ÿ“ Hangzhou๐Ÿ“ Hangzhou๐Ÿ“ Huzhou Yu jiren ยท Tests: Toripalimab, Oxaliplatin, S1 IBI343 in Combination With Sintilimab and SOX Regimen for Perioperative Treatment of Resectable, Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma NCT07483567Phase 21 site๐Ÿ“ Beijing Innovent Biologics (Suzhou) Co. Ltd. ยท Tests: IBI343,sintilimab,oxaliplatin,S-1, sintilimab,oxaliplatin,S-1 QLS31905 in Combination With CAPOX Versus Sintilimab in Combination With CAPOX as First-line Treatment in Patients With GC/GEJ NCT07716449Phase 31 site๐Ÿ“ Beijing Qilu Pharmaceutical Co., Ltd. ยท Tests: QLS31905, Sintilimab, Oxaliplatin, Capecitabine Utidelone Capsule Combined With Fluoropyrimidine- and Platinum-containing Therapy in First-line Treatment of Patients With Gastric or Gastroesophageal Junction Adenocarcinoma NCT06841679Phase 2, Phase 310 sites๐Ÿ“ Hialeah๐Ÿ“ Anyang๐Ÿ“ Guangzhou Beijing Biostar Pharmaceuticals Co., Ltd. ยท Tests: Utidelone Capsule, Utidelone Capsule, Utidelone Capsule, Fluoropyrimidine- and Platinum-containing Therapy, Oxaliplatin An Open Label Phase 2 Study of Total Neoadjuvant Therapy (TNT) Consisting of FLOT With Pembrolizumab and Short Radiation for Patients With Locally Advanced Gastroesophageal Junction Adenocarcinoma NCT07018570Phase 21 site๐Ÿ“ Kashiwa National Cancer Center Hospital East ยท Tests: Pembrolizumab, Docetaxel, Oxaliplatin, Levofolinate, Fluorouracil (5-FU) Apatinib as the First-Line Therapy in Elderly Locally Advanced or Metastatic Gastric Cancer NCT03219593Phase 21 site๐Ÿ“ Bengbu The First Affiliated Hospital of Bengbu Medical University ยท Tests: Apatinib mesylate tablets Neoadjuvant Apatinib Combined With Sintilimab and Perioperative SOX Versus Neoadjuvant Sintilimab Combined With Perioperative SOX for Intestinal Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma NCT06925243Phase 34 sites๐Ÿ“ Lanzhou๐Ÿ“ Lanzhou๐Ÿ“ Lanzhou Zuoyi Jiao ยท Tests: Neoadjuvant apatinib combined with sintilimab and perioperative SOX, Neoadjuvant sintilimab combined with perioperativeโ€ฆ Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma NCT05651594Phase 21 site๐Ÿ“ Buffalo Roswell Park Cancer Institute ยท Tests: Biopsy, Biospecimen Collection, Computed Tomography, Fluorouracil, Leucovorin Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06) NCT06469944Phase 1, Phase 250 sites๐Ÿ“ Tucson๐Ÿ“ Los Angeles๐Ÿ“ Louisville Merck Sharp & Dohme LLC ยท Tests: Pembrolizumab, Sacituzumab Tirumotecan (sac-TMT), Capecitabine, Leucovorin, Levoleucovorin A Multicenter Randomized Controlled Phase II Trial of Iparomlimab and Tuvonralimab (QL1706) Combined With SOX Chemotherapy Versus Chemotherapy Alone in the Treatment of Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma NCT06829797Phase 21 site๐Ÿ“ Jinan Shandong Provincial Hospital ยท Tests: Neoadjuvant Therapy(QL1706+SOX Chemotherapy), Neoadjuvant Therapy(SOX Chemotherapy), Radical surgery (D2), Drug: Adjuvaโ€ฆ Tislelizumab in Combination With Pre-operative CRT Versus SOC for Locally Advanced G/GEJ Adenocarcinoma NCT05687357Phase 23 sites๐Ÿ“ Wuhan๐Ÿ“ Nanjing๐Ÿ“ Taiyuan The Affiliated Nanjing Drum Tower Hospital of Nanjing Univeโ€ฆ ยท Tests: Tislelizumab, S-1, Oxaliplatin, Nab paclitaxel, Radiation S-1 and Oxaliplatin (SOX) Plus Sintilimab in the Locally Advanced Esophagogastric Junction Adenocarcinoma NCT04989985Phase 21 site๐Ÿ“ Guangzhou Sixth Affiliated Hospital, Sun Yat-sen University ยท Tests: Oxaliplatin+S-1, Sinitilimab+oxaliplatin+S-1 Perioperative HLX10 (Serplulimab) With S-1+Oxaliplatin (SOX) in Locally Advanced and PD-L1-Positive Gastric or Esophagogastric Junction Adenocarcinoma NCT07699939Phase 218 sites๐Ÿ“ Chiba๐Ÿ“ Fukuoka๐Ÿ“ Gifu National Cancer Center, Japan ยท Tests: serplulimab, Placebo A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors NCT07488676Phase 1, Phase 221 sites๐Ÿ“ Birmingham๐Ÿ“ Los Angeles๐Ÿ“ Miami Astellas Pharma Global Development, Inc. ยท Tests: ASP546C Tislelizumab Plus FOLFOX Versus POF in the Treatment of Locally Advanced: a Multicenter, Open-label, Randomized Phase III Studyunresectable or Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma NCT06793917Phase 31 site๐Ÿ“ Fuzhou Fujian Cancer Hospital ยท Tests: Tislelizumab, Oxaliplatin injection, Levo-Leucovorin, 5-fluorouracil, Paclitaxel
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