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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Locally Advanced Head-and-Neck Cancer

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma NCT03556228Phase 1, Phase 215 sites📍 Santa Rosa📍 Hartford📍 Washington D.C. VM Oncology, LLC · Tests: VMD-928 100 mg Tablet, VMD-928 Tablet and Pembrolizumab (200 mg) Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) NCT06780111Phase 1, Phase 252 sites📍 Pittsburgh📍 Natal📍 Porto Alegre Merck Sharp & Dohme LLC · Tests: Pembrolizumab, I-DXd, Leucovorin, Levoleucovorin, 5-Fluorouracil (5-FU) Postoperative Radiotherapy Followed by Immunotherapy for Locally Advanced Esophageal Carcinoma NCT05937438Phase 1, Phase 21 site📍 Hefei Anhui Provincial Hospital · Tests: Immune Checkpoint Inhibitors A Phase II Study of Toripalimab Combined With Sequential Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma NCT06843889Phase 21 site📍 Guangzhou Nanfang Hospital, Southern Medical University · Tests: Toripalimab (240mg day1, Q3W*3cycle) Effect of Immunonutrients on Oral Mucositis in Nasopharyngeal Carcinoma Patients After Chemoradiotherapy NCT05892354NA20 sites📍 Fuzhou📍 Fuzhou📍 Guangzhou First Affiliated Hospital of Guangxi Medical University · Tests: Enteral immunonutrition, Standard enteral nutrition Nimotuzumab Plus Definite Chemoradiotherapy(dCRT) in Elderly Patients With Esophageal Squamous Cell Carcinoma NCT06988956Phase 21 site📍 Nanjing The First Affiliated Hospital with Nanjing Medical Universi… · Tests: Nimotuzumab, Tegafur, radiotherapy Efficacy and Safety of Penpulimab Combined With Anlotinib and Chemotherapy NCT06586242Phase 21 site📍 Xi'an Xijing Hospital · Tests: Penpulimab;Anlotinib;albumin paclitaxel;oxaliplatin;lobaplatin Efficacy and Safety of PD-1 Plus Chemotherapy in Poorly Differentiated Locally Advanced (LA) HNSCC NCT06100497Phase 21 site📍 Beijing Beijing Tongren Hospital · Tests: Pembrolizumab, Cisplatin, Paclitaxel-albumin Induction Chemo-Immunotherapy + Radiotherapy vs Concurrent Chemoradiotherapy for Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma NCT07559045Phase 21 site📍 Zunyi Second Affiliated Hospital of Zunyi Medical University · Tests: Paclitaxel plus Cisplatin or Carboplatin (Induction Chemotherapy), Weekly Paclitaxel plus Cisplatin or Carboplatin (Con… Low-dose Radiation Combined With Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma NCT06446726Phase 21 site📍 Chengdu Sichuan University · Tests: Tislelizumab, Low-dose radiotherapy, Nab-paclitaxel, Cisplatin Proton vs Photon IMRT in Locally Advanced Nasopharyngeal Carcinoma: A Phase III Trial NCT07340515Phase 31 site📍 Jinan Man Hu · Tests: Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT), Cisplatin, Toripalimab Hypofractionated vs. Conventional Chemoradiotherapy After Induction Chemo-immunotherapy for Unresectable Esophageal Squamous Cell Carcinoma NCT06912074Phase 21 site📍 Guangzhou Sun Yat-sen University · Tests: Induction chemoimmunotherapy, Hypofractionated Radiation Therapy, Conventional Fractionated Radiation Therapy, Concurre… A Study of SI-B003, BL-B01D1+SI-B003 and BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Esophageal Cancer, Gastric Cancer, Colorectal Cancer and Other Gastrointestinal Tumors NCT06008054Phase 21 site📍 Beijing Sichuan Baili Pharmaceutical Co., Ltd. · Tests: SI-B003, BL-B01D1, PD-1 Monoclonal Antibody Chemoradiation Plus Iparomlimab Consolidation in Older With ESCC NCT07038629Phase 21 site📍 Tianjin Tianjin Medical University Cancer Institute and Hospital · Tests: S1, Iparomlimab, Radiation PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC NCT07332247Phase 21 site📍 Guangzhou Sun Yat-sen University · Tests: Selective re-irradiation, Immediate re-irradiation Adaptive RadioTherapy for OroPharynx Cancer NCT04901234Phase 22 sites📍 Melbourne📍 Montreal Centre hospitalier de l'Université de Montréal (CHUM) · Tests: Standard radiotherapy +/- chemotherapy, Experimental radiotherapy +/- chemotherapy Neoadjuvant EGFR-ADC Combined With Anti-PD-1 Monoclonal Antibody in Resectable Locally Advanced Hypopharyngeal Squamous Cell Carcinoma NCT07665190Phase 21 site📍 Tianjin Tianjin Medical University Cancer Institute and Hospital · Tests: Becotatug Vedotin and Pucotenlimab Neoadjuvant ChemoRadiotherapy Followed by Immunotherapy and Surgery for Resectable Esophageal Squamous Cell Carcinoma（CRIS-2 Trial） NCT06509568Phase 21 site📍 Hangzhou Zhejiang Cancer Hospital · Tests: Neoadjuvant chemoradiotherapy followed by immunotherapy, Neoadjuvant chemoimmunotherapy A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Gastrointestinal Tumor and Other Solid Tumor NCT05262491Phase 16 sites📍 Beijing📍 Nanchang📍 Jinan Sichuan Baili Pharmaceutical Co., Ltd. · Tests: BL-B01D1 Nimotuzumab Combined With Immunotherapy and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma NCT07601737Phase 21 site📍 Shanghai Shanghai General Hospital, Shanghai Jiao Tong University Sc… · Tests: Nimotuzumab Injection, Tislelizumab, Albumin-Bound Paclitaxel /nab-Paclitaxel, Cisplatin (Or Carboplatin), Radical surg… Molecular-Based Selection of Patients with Head and Neck Squamous Cell Carcinoma: Biomarker Analysis NCT06905145n/a1 site📍 Naples National Cancer Institute, Naples · Tests: Biomarkers evaluation Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Advanced Head and Neck Cancer Who Cannot Receive Cisplatin NCT07441681Phase 3150 sites📍 Birmingham📍 Anaheim📍 Baldwin Park NRG Oncology · Tests: Biospecimen Collection, Carboplatin, Cetuximab, Computed Tomography, Intensity-Modulated Radiation Therapy Adebrelimab ±Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Unresectable Locally Advanced ESCC NCT06510660Phase 21 site📍 Fuzhou Fujian Medical University Union Hospital · Tests: adebrelimab EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors NCT07410676Phase 1, Phase 21 site📍 Beijing Essen Biotech · Tests: EBNK-001 + IL-15 + Pembrolizumab Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors NCT06975410Phase 1, Phase 24 sites📍 Seoul📍 Seoul📍 Seoul Yuhan Corporation · Tests: YH32364 A Single-arm, Open, Single-center Exploratory Study of Adebrelimab (SHR-1316) in Combination With Chemotherapy for the Perioperative Treatment of Locally Advanced Resectable Esophageal Squamous Carcinoma NCT06869213Phase 21 site📍 Beijing Peking University Cancer Hospital & Institute · Tests: Adebrelimab (SHR-1316) + Nab-paclitaxel + Cisplatin A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F) NCT07405151Phase 1, Phase 232 sites📍 Pittsburgh📍 Natal📍 Porto Alegre Merck Sharp & Dohme LLC · Tests: I-DXd, Rescue Medication Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer NCT04415853Phase 31 site📍 Beijing Sunshine Lake Pharma Co., Ltd. · Tests: Lerotinib, Irinotecan/Tegafur Sacituzumab Govitecan Combined With Tislelizumab for Locally Advanced/Metastatic Esophageal Cancer NCT07811752Phase 22 sites📍 Shanghai📍 Shanghai Shanghai Chest Hospital · Tests: Sacituzumab Tirumotecan (SKB264) plus Tislelizumab A Study of AL2846 Capsule Versus Placebo in the Treatment of Advanced Radioiodine-Refractory Differentiated Thyroid Carcinoma NCT06860971Phase 335 sites📍 Hefei📍 Beijing📍 Chongqing Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Tests: AL2846 Capsules, AL2846 Placebo
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