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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Locally Advanced Malignant Solid Neoplasm

Imaging of Solid Tumors Using 18F-TRX NCT06942104Phase 11 site๐Ÿ“ San Francisco Rahul Aggarwal ยท Tests: 18F-TRX, Positron Emission Tomography (PET)/Computerized tomography (CT), Tumor Biopsy, Blood Specimen Collection A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy NCT06362369Phase 1, Phase 25 sites๐Ÿ“ Aurora๐Ÿ“ Lake Mary๐Ÿ“ Lebanon 7 Hills Pharma, LLC ยท Tests: Alintegimod, Ipilimumab, Nivolumab A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1) NCT06521554Phase 121 sites๐Ÿ“ Irvine๐Ÿ“ Sacramento๐Ÿ“ Stanford Nuvalent Inc. ยท Tests: NVL-330 A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC278 in the Treatment of Solid Tumors NCT07105215Phase 1, Phase 239 sites๐Ÿ“ Beijing๐Ÿ“ Fuzhou๐Ÿ“ Fuzhou RemeGen Co., Ltd. ยท Tests: RC278 A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1) NCT05118789Phase 1, Phase 263 sites๐Ÿ“ Orange๐Ÿ“ Palo Alto๐Ÿ“ Sacramento Nuvalent Inc. ยท Tests: Zidesamtinib (NVL-520) IBI3001 in Participants With Unresectable, Locally Advanced or Metastatic Solid Tumors NCT06349408Phase 127 sites๐Ÿ“ Los Angeles๐Ÿ“ East Brunswick๐Ÿ“ Dallas Fortvita Biologics (USA)Inc. ยท Tests: IBI3001 Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors NCT06975410Phase 1, Phase 24 sites๐Ÿ“ Seoul๐Ÿ“ Seoul๐Ÿ“ Seoul Yuhan Corporation ยท Tests: YH32364 A I/II Phase Clinical Study to Evaluate the Safety and Efficacy of RC288 in the Treatment of Solid Tumors NCT07537881Phase 1, Phase 214 sites๐Ÿ“ Hunan๐Ÿ“ Sichuan๐Ÿ“ Fujian RemeGen Co., Ltd. ยท Tests: RC288 For Injection, RC288 For Injection Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors NCT06416007Phase 21 site๐Ÿ“ Cincinnati University of Cincinnati ยท Tests: Lattice therapy (LRT) GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors NCT06265025Phase 1, Phase 24 sites๐Ÿ“ Goyang-si๐Ÿ“ Seoul๐Ÿ“ Seoul GeneMedicine Co., Ltd. ยท Tests: GM103 (Part A), GM103 (Part B), GM103 and Pembrolizumab (Part C) Adapting Treatment to the Tumor Molecular Alterations for Patients With Advanced Solid Tumors: MyOwnSpecificTreatment NCT02029001Phase 27 sites๐Ÿ“ Bordeaux๐Ÿ“ Lyon๐Ÿ“ Lyon Centre Leon Berard ยท Tests: Nilotinib (400 mg BID), Everolimus (10 mg QD), Sorafenib (400 mg BID), Lapatinib (1500 mg QD), Pazopanib (800 mg QD) Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rฮฑ Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer NCT05267626Phase 1, Phase 217 sites๐Ÿ“ Miami๐Ÿ“ Grand Rapids๐Ÿ“ Minneapolis Aulos Bioscience, Inc. ยท Tests: AU-007, Aldesleukin, Avelumab, Nivolumab DBC-664 in Adult Patients With Solid Tumors NCT07705035Phase 17 sites๐Ÿ“ Denver๐Ÿ“ Grand Rapids๐Ÿ“ St Louis Duboce Biopharmaceuticals, Inc. ยท Tests: DBC-664 Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer NCT07137416Phase 12 sites๐Ÿ“ Boston๐Ÿ“ St Louis National Cancer Institute (NCI) ยท Tests: Biopsy Procedure, Biospecimen Collection, Echocardiography Test, Multigated Acquisition Scan, Pidnarulex PE0116 and PE0105 Injection in Treatment of Patients With Advanced Solid Tumor NCT05801237Phase 1, Phase 21 site๐Ÿ“ Shanghai Shanghai HyaMab Biotech Co.,Ltd. ยท Tests: PE0116&PE0105 Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program NCT06265285Phase 21 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Home Health Encounter, Nivolumab, Patient Monitoring, Questionnaire Administration Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid Tumors, DURVA+ Trial NCT03907475Phase 21 site๐Ÿ“ Bethesda National Cancer Institute (NCI) ยท Tests: Biopsy Procedure, Biospecimen Collection, Capecitabine, Carboplatin, Computed Tomography A Study to Assess the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, Immunogenicity and Antitumour Activity of IPN60300 in Adults With Locally Advanced or Metastatic Solid Tumours NCT07213817Phase 1, Phase 212 sites๐Ÿ“ New Haven๐Ÿ“ Grand Rapids๐Ÿ“ Philadelphia Ipsen ยท Tests: IPN60300 CD8 PET Imaging in Metastatic Solid Tumours NCT06534190Phase 24 sites๐Ÿ“ Amsterdam๐Ÿ“ Groningen๐Ÿ“ Barcelona University Medical Center Groningen ยท Tests: 89Zr-Df-crefmirlimab PET scan, Nivolumab, Cetrelimab, zirconium Zr 89 crefmirlimab berdoxam A Study of TAK-505 in Adults With Solid Tumors NCT07436728Phase 1, Phase 215 sites๐Ÿ“ Orange๐Ÿ“ San Diego๐Ÿ“ San Francisco Takeda ยท Tests: TAK-505 A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations NCT04094610Phase 1, Phase 268 sites๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles๐Ÿ“ Aurora Turning Point Therapeutics, Inc. ยท Tests: Oral repotrectinib (TPX-0005) Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial NCT05564377Phase 2484 sites๐Ÿ“ Birmingham๐Ÿ“ Mobile๐Ÿ“ Anchorage National Cancer Institute (NCI) ยท Tests: Alpelisib, Binimetinib, Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors NCT04879121Phase 21 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Larotrectinib Sulfate A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression NCT06051695Phase 1, Phase 212 sites๐Ÿ“ Gilbert๐Ÿ“ La Jolla๐Ÿ“ Los Angeles A2 Biotherapeutics Inc. ยท Tests: A2B694, A2B543, xT CDx with HLA-LOH Assay Parenting Support Intervention for Families Coping With Metastatic or Locally Recurrent Solid Tumor Diagnosis NCT05059678NA1 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Best Practice, Educational Intervention, Questionnaire Administration A Dose Escalation and Expansion Study of [177Lu]Lu-SN201 in Participants With Advanced Cancer NCT06184035Phase 1, Phase 22 sites๐Ÿ“ Adelaide๐Ÿ“ Melbourne Spago Nanomedical AB ยท Tests: [177Lu]Lu-SN201 A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1) NCT05384626Phase 1, Phase 274 sites๐Ÿ“ Orange๐Ÿ“ Sacramento๐Ÿ“ Stanford Nuvalent Inc. ยท Tests: Neladalkib (NVL-655), Midazolam, Repaglinide, Itraconazole A Study on the Prevalence of Clinically Useful Mutations in Solid Tumor Characterized by Next Generation Sequencing Methods on Liquid Biopsy Analysis (POPCORN) NCT06028724n/a1 site๐Ÿ“ Aviano Centro di Riferimento Oncologico - Aviano Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors NCT06545942Phase 118 sites๐Ÿ“ Goodyear๐Ÿ“ La Jolla๐Ÿ“ San Francisco MOMA Therapeutics ยท Tests: MOMA-313, Olaparib Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning NCT04515810NA4 sites๐Ÿ“ Manhasset๐Ÿ“ New York๐Ÿ“ New York Fred Hutchinson Cancer Center ยท Tests: Internet-Based Intervention, Best Practice, Telephone-Based Intervention, Questionnaire Administration, Post-interventiโ€ฆ
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