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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Locally Advanced Rectal Carcinoma

SCRT VS LCRT Followed by PD-L1 Inhibitor Plus CAPEOX as TNT in Patients With LARC NCT07284992Phase 21 site๐Ÿ“ Jinan Shandong Provincial Hospital ยท Tests: short-term radiotherapy combined with Adebrelimab and capox, long-term radiotherapy combined with Adebrelimab and capox A Study of Tucatinib and Trastuzumab in People With Rectal Cancer NCT05672524Phase 27 sites๐Ÿ“ Basking Ridge๐Ÿ“ Middletown๐Ÿ“ Montvale Memorial Sloan Kettering Cancer Center ยท Tests: Trastuzumab, Tucatinib Organ Preservation in Locally Advanced Rectal Cancer NCT03064646NA1 site๐Ÿ“ Elche Fundaciรณn para el Fomento de la Investigaciรณn Sanitaria y Bโ€ฆ ยท Tests: Organ Preservation Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer. NCT06940388Phase 22 sites๐Ÿ“ Mainz๐Ÿ“ Petah Tikva brenner baruch ยท Tests: Tislelizumab, Total neoadjuvant therapy (TNT) MR-guided Adaptive Radiotherapy Combined With PD-1 Antibody and CAPOX for Locally Advanced Rectal Cancer NCT06840665Phase 21 site๐Ÿ“ Shanghai Fudan University ยท Tests: PD-1 antibody, Oxaliplatin, Capecitabine Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoadjuvant Treatment of Patients With Locally Advanced HER2-positive Rectal Cancer NCT07108127Phase 21 site๐Ÿ“ Beijing Peking Union Medical College Hospital ยท Tests: Trastuzumab biosimilars and pertuzumab biosimilars plus XELOX Application of PET/MRI in the Evaluation of the Efficacy of Neoadjuvant Therapy for Locally Advanced Rectal Cancer NCT06653452NA1 site๐Ÿ“ Beijing Peking Union Medical College Hospital ยท Tests: 18F-FDG PET/CT and PET/MR scan, 68Ga-FAPI-04 PET/CT and PET/MR scan To Explore the Efficacy of Sintilimab Combined With Bevacizumab in Rectal Cancer NCT06808412Phase 21 site๐Ÿ“ Xi'an xiaohua li ยท Tests: sintilimab combined with bevacizumab and XELOX UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer NCT05148767Phase 41 site๐Ÿ“ Hangzhou Zhejiang Cancer Hospital ยท Tests: Neoadjuvant chemoradiotherapy based on irinotecan Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer NCT07528209Phase 31 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Pucotenlimab combine with CAPOX, CAPOX Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy NCT05965531Phase 21 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Trifluridine/Tipiracil, intensity-modulated radiotherapy Short-course Radiotherapy Followed by Sequential Chemotherapy With or Without PD-1 Monoclonal Antibody and Bevacizumab as Total Neoadjuvant Therapy in pMMR/MSS Locally Advanced Rectal Cancer ๏ผˆSPARK๏ผ‰ NCT07005570Phase 21 site๐Ÿ“ Guangzhou Dechang Diao ยท Tests: Short-course radiotherapy followed by sequential chemotherapy combined with PD-1 monoclonal antibody and bevacizumab, Sโ€ฆ Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I) NCT06923345Phase 21 site๐Ÿ“ Guangzhou Sixth Affiliated Hospital, Sun Yat-sen University ยท Tests: Reduced CTV, Conventional CTV A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors NCT06440005Phase 17 sites๐Ÿ“ Los Angeles๐Ÿ“ Sarasota๐Ÿ“ St Louis Angiex, Inc. ยท Tests: AGX101 A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy NCT06362369Phase 1, Phase 25 sites๐Ÿ“ Aurora๐Ÿ“ Lake Mary๐Ÿ“ Lebanon 7 Hills Pharma, LLC ยท Tests: Alintegimod, Ipilimumab, Nivolumab Short-Course Radiotherapy Followed by Immunotherapy Combined With Chemotherapy for Microsatellite Stable Locally Advanced Rectal Cancer: A Prospective, Randomized, Controlled Phase II Clinical Trial NCT07594925Phase 21 site๐Ÿ“ Tianjin Tianjin Medical University Cancer Institute and Hospital ยท Tests: Sintilimab, Chemotherapy Drugs, radiotherapy Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal Cancer NCT07686640Phase 31 site๐Ÿ“ Jinan Shandong Cancer Hospital and Institute ยท Tests: Short-Course Radiotherapy, Consolidation treatment (With ICIs), Consolidation treatment (Without ICIs) SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer NCT05412082Phase 11 site๐Ÿ“ Miami University of Miami ยท Tests: Intensity-modulated radiation therapy, 5-fluorouracil, Leucovorin, Oxaliplatin, Capecitabine EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ยฑ Pembrolizumab in Advanced Solid Tumors NCT07410676Phase 1, Phase 21 site๐Ÿ“ Beijing Essen Biotech ยท Tests: EBNK-001 + IL-15 + Pembrolizumab GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors NCT06265025Phase 1, Phase 24 sites๐Ÿ“ Goyang-si๐Ÿ“ Seoul๐Ÿ“ Seoul GeneMedicine Co., Ltd. ยท Tests: GM103 (Part A), GM103 (Part B), GM103 and Pembrolizumab (Part C) Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT) NCT06770270Phase 21 site๐Ÿ“ Hangzhou Second Affiliated Hospital, Zhejiang University, School of โ€ฆ ยท Tests: Pucotenlimab THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI Guided Radiotherapy NCT04815694NA1 site๐Ÿ“ Roma Fondazione Policlinico Universitario Agostino Gemelli IRCCS ยท Tests: RT Dose escalation in LARC patients with an Early Regression Index > 13.1 at second week on nCRT Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients NCT06812728Phase 21 site๐Ÿ“ Shibฤซn al Kawm Menoufia University ยท Tests: mFOLFIRINOX, mFolfox6 Study of IBI3028 in Participants With Locally Advanced, Unresectable, or Metastatic Solid Tumors NCT07589205Phase 11 site๐Ÿ“ Tianjin Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. ยท Tests: Drug: IBI3028 Galenos 2 Immunonutrition in Head and Neck, Lung, and Rectal Cancer Patients NCT07514754NA1 site๐Ÿ“ Candiolo Fondazione del Piemonte per l'Oncologia ยท Tests: Galenic Immunonutrition Formula A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression NCT06682793Phase 1, Phase 210 sites๐Ÿ“ Gilbert๐Ÿ“ La Jolla๐Ÿ“ Los Angeles A2 Biotherapeutics Inc. ยท Tests: A2B395, xT CDx with HLA-LOH assay GALENOS 1 in Head and Neck, Lung, and Rectal Cancer Patients NCT07511413n/a1 site๐Ÿ“ Candiolo Fondazione del Piemonte per l'Oncologia Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer NCT05245474Phase 28 sites๐Ÿ“ Beijing๐Ÿ“ Beijing๐Ÿ“ Beijing Beijing Friendship Hospital ยท Tests: Long-course chemoradiation, with or without Tislelizumab (PD-1 inhibitor) A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX Chemotherapy Versus Long-Course Chemoradiotherapy for High-Risk Locally Advanced pMMR/MSS Lower Rectal Adenocarcinoma (STAR Trial) NCT07669220Phase 21 site๐Ÿ“ Guangzhou Sixth Affiliated Hospital, Sun Yat-sen University ยท Tests: Short-course Radiotherapy, SCRT, Toripalimab ADAR1 Expression Level in Rectal Cancer NCT07108348n/a1 site๐Ÿ“ Konya Necmettin Erbakan University ยท Tests: Adenosine deaminase acting on RNA1
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