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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Locally Advanced or Metastatic Digestive Tract Tumors

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma NCT03556228Phase 1, Phase 215 sites๐Ÿ“ Santa Rosa๐Ÿ“ Hartford๐Ÿ“ Washington D.C. VM Oncology, LLC ยท Tests: VMD-928 100 mg Tablet, VMD-928 Tablet and Pembrolizumab (200 mg) Phase I Clinical Study of BL-M07D1 in Locally Advanced or Metastatic Digestive Tract Tumors and Other Solid Tumors NCT05631964Phase 11 site๐Ÿ“ Shanghai Sichuan Baili Pharmaceutical Co., Ltd. ยท Tests: BL-M07D1 A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy NCT06362369Phase 1, Phase 25 sites๐Ÿ“ Aurora๐Ÿ“ Lake Mary๐Ÿ“ Lebanon 7 Hills Pharma, LLC ยท Tests: Alintegimod, Ipilimumab, Nivolumab EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ยฑ Pembrolizumab in Advanced Solid Tumors NCT07410676Phase 1, Phase 21 site๐Ÿ“ Beijing Essen Biotech ยท Tests: EBNK-001 + IL-15 + Pembrolizumab Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors NCT06975410Phase 1, Phase 24 sites๐Ÿ“ Seoul๐Ÿ“ Seoul๐Ÿ“ Seoul Yuhan Corporation ยท Tests: YH32364 Phase II Study of Trastuzumab Rezetecan Combined With Adebrelimab and Lenvatinib in Advanced HER2-Positive/Low-Expression Biliary Tract Cancer NCT07704177Phase 21 site๐Ÿ“ Beijing Peking Union Medical College Hospital ยท Tests: Trastuzumab Rezetecan, Adebrelimab, Lenvatinib Study of IBI3028 in Participants With Locally Advanced, Unresectable, or Metastatic Solid Tumors NCT07589205Phase 11 site๐Ÿ“ Tianjin Innovent Biopharmaceutical Technology (Hangzhou) Co., LTD. ยท Tests: Drug: IBI3028 Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rฮฑ Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer NCT05267626Phase 1, Phase 217 sites๐Ÿ“ Miami๐Ÿ“ Grand Rapids๐Ÿ“ Minneapolis Aulos Bioscience, Inc. ยท Tests: AU-007, Aldesleukin, Avelumab, Nivolumab A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression NCT06682793Phase 1, Phase 210 sites๐Ÿ“ Gilbert๐Ÿ“ La Jolla๐Ÿ“ Los Angeles A2 Biotherapeutics Inc. ยท Tests: A2B395, xT CDx with HLA-LOH assay AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors NCT07454642Phase 17 sites๐Ÿ“ Scottsdale๐Ÿ“ Sarasota๐Ÿ“ Chicago Avacta Life Sciences Ltd ยท Tests: AVA6103 A Study of SH009 Injection in Patients With Advanced Solid Tumors. NCT07390838Phase 11 site๐Ÿ“ Shanghai Nanjing Sanhome Pharmaceutical, Co., Ltd. ยท Tests: SH009 Study of XB010 in Subjects With Solid Tumors NCT06545331Phase 120 sites๐Ÿ“ Irvine๐Ÿ“ Los Angeles๐Ÿ“ Washington D.C. Exelixis ยท Tests: XB010, Pembrolizumab A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements NCT03093116Phase 1, Phase 2165 sites๐Ÿ“ Duarte๐Ÿ“ Glendale๐Ÿ“ La Jolla Turning Point Therapeutics, Inc. ยท Tests: Oral repotrectinib (TPX-0005) A Study of BL-M07D1 Versus Physician's Choice of Chemotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Biliary Tract Cancer After Platinum-containing Chemotherapy Failure NCT07606599Phase 32 sites๐Ÿ“ Hefei๐Ÿ“ Beijing Sichuan Baili Pharmaceutical Co., Ltd. ยท Tests: BL-M07D1, Oxaliplatin, Calcium levofolinate, Fluorouracil, Irinotecan Hydrochloride Liposome Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma NCT06582017Phase 111 sites๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles Nammi Therapeutics Inc ยท Tests: QXL138AM Injection every 2 weeks by IV Infusion Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC NCT05733598Phase 212 sites๐Ÿ“ Beverly Hills๐Ÿ“ La Jolla๐Ÿ“ Miami Replimune, Inc. ยท Tests: RP2, Bevacizumab, Atezolizumab, Durvalumab, RP2 Monotherapy 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors NCT07189871Phase 1, Phase 25 sites๐Ÿ“ Dothan๐Ÿ“ Grand Rapids๐Ÿ“ Omaha Radiopharm Theranostics, Ltd ยท Tests: 177Lu-BetaBart, BetaBart + unlabeled BetaBart The Effect of Kinisoquinโ„ข on Thromboembolic Events in Patients With Metastatic or Locally Advanced Pancreatic Cancer NCT06861088Phase 33 sites๐Ÿ“ Ventura๐Ÿ“ Miami Lakes๐Ÿ“ Boston Quercis Pharma AG ยท Tests: Kinisoquinโ„ข, Placebo A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors NCT07094204Phase 122 sites๐Ÿ“ Santa Monica๐Ÿ“ Atlanta๐Ÿ“ Jefferson Astellas Pharma Inc ยท Tests: ASP5834, panitumumab A Study of TQB2102 for Injection in the Treatment of HER2-positive Biliary Tract Cancer NCT06431490Phase 1, Phase 243 sites๐Ÿ“ Fuyang๐Ÿ“ Hefei๐Ÿ“ Hefei Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharโ€ฆ ยท Tests: TQB2102 for injection A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression NCT06051695Phase 1, Phase 212 sites๐Ÿ“ Gilbert๐Ÿ“ La Jolla๐Ÿ“ Los Angeles A2 Biotherapeutics Inc. ยท Tests: A2B694, A2B543, xT CDx with HLA-LOH Assay Y-90 With Durvalumab/Gem/Cis in Intrahepatic Cholangio NCT05655949Phase 21 site๐Ÿ“ Boston Beth Israel Deaconess Medical Center ยท Tests: Gemcitabine, Cisplatin, Durvalumab, Yttrium-90 Clinical Trial of YH32367 in Patients With HER2 Positive Locally Advanced or Metastatic Solid Tumor NCT05523947Phase 1, Phase 219 sites๐Ÿ“ Boston๐Ÿ“ Nashville๐Ÿ“ Adelaide Yuhan Corporation ยท Tests: YH32367 A Study to Investigate the Safety, Pharmacokinetics, and Clinical Activity of AP203 in Patients with Locally Advanced or Metastatic Solid Tumors, and Expansion to Selected Malignancies NCT05473156Phase 1, Phase 21 site๐Ÿ“ Taipei AP Biosciences Inc. ยท Tests: AP203, AP203 Phase II Study of Trastuzumab Rezetecan Combined With Adebrelimab and Lenvatinib as First-Line Therapy for Advanced HER2-Positive/HER2-Low Biliary Tract Cancer NCT07670273Phase 21 site๐Ÿ“ Beijing Peking Union Medical College Hospital ยท Tests: Trastuzumab Rezetecan, Adebrelimab, Lenvatinib A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas NCT06999187Phase 110 sites๐Ÿ“ Denver๐Ÿ“ Orlando๐Ÿ“ Sarasota Dren Bio ยท Tests: DR-0202 A Study of BL-M07D1 in Patients With a Variety of Solid Tumors Including Locally Advanced or Metastatic HER2-positive/Low-expressing Urinary and Gastrointestinal Tumors NCT06031584Phase 1, Phase 21 site๐Ÿ“ Beijing Sichuan Baili Pharmaceutical Co., Ltd. ยท Tests: BL-M07D1 Alternating Chemo-immunotherapy and FGFR Inhibitor for FGFR-positive Biliary or Cholangiocarcinoma NCT07780838Phase 21 site๐Ÿ“ Columbus Ohio State University Comprehensive Cancer Center ยท Tests: Biospecimen Collection, Cisplatin, Computed Tomography, Durvalumab, Gemcitabine AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001) NCT07038343Phase 1, Phase 227 sites๐Ÿ“ Gilbert๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles Avenzo Therapeutics, Inc. ยท Tests: AVZO-1418, Combination Agent 1, Combination Agent 2 A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors NCT07229313Phase 17 sites๐Ÿ“ Santa Monica๐Ÿ“ New Have๐Ÿ“ Camperdown Kivu Bioscience Inc. ยท Tests: KIVU-107
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