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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Major Depressive Disorder

A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder NCT06958692Phase 31 site๐Ÿ“ Beijing CSPC Ouyi Pharmaceutical Co., Ltd. ยท Tests: Dextromethorphan and Bupropion Sustained-Release Tablets, Placebo Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity NCT07136714Phase 41 site๐Ÿ“ Hillerรธd Nordsjaellands Hospital ยท Tests: Semaglutide Injectable Product, Placebo Near Infrared Spectroscopy (NIRS) for Assessment of Depression NCT04061148NA1 site๐Ÿ“ San Francisco University of California, San Francisco ยท Tests: NIRSIT Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study NCT07247968EARLY Phase 12 sites๐Ÿ“ Chongqing๐Ÿ“ Chongqing Min Su ยท Tests: Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume) Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits NCT06728774NA1 site๐Ÿ“ Portland Portland VA Medical Center ยท Tests: Motivationally Enhanced Compensatory Cognitive Training for Major Depressive Disorder (ME-CCT-MDD), Goal-focused Supporโ€ฆ Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults NCT06860724NA1 site๐Ÿ“ Newark University of Delaware ยท Tests: NG-nitro-L-arginine methyl ester (L-NAME) Adjunctive Bright Light Therapy in Adolescents With Depression and Eveningness NCT06973759NA1 site๐Ÿ“ Hong Kong Chinese University of Hong Kong ยท Tests: Bright light therapy, Dim red light Gender Differences in Depression Severity, Gender-Sensitive Symptoms, Resilience, and Stigma in Major Depressive Disorder NCT07474363n/a1 site๐Ÿ“ EskiลŸehir Eskisehir Osmangazi University Nutritional Intervention for College Students With Depression NCT07490782NA1 site๐Ÿ“ La Jolla University of California, San Diego ยท Tests: Mediterranean Diet, Time-Restricted Eating Psychoeducational Group for Depression NCT06467474NA1 site๐Ÿ“ Sรฃo Paulo Ricardo Alberto Moreno, M.D., Ph.D. ยท Tests: PEG-D program, TAU TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children NCT07478796Phase 41 site๐Ÿ“ Poznan Poznan University of Medical Sciences ยท Tests: Fluoxetine, Escitalopram, Sertralin Lifestyle Interventions to Prevent cOgnitive Deficits in Subjects With Depressive Symptoms: From mEchanisms to Clinical pRactice NCT07462013NA1 site๐Ÿ“ Taichung National Science and Technology Council, Taiwan ยท Tests: Soybean oil (Standard treatment), Eicosapentaenoic acid (omega-3 fatty acid) Efficacy of Chronotherapeutic Combination for Major Depressive Episode With Insomnia NCT07120880Phase 31 site๐Ÿ“ Paris Assistance Publique - Hรดpitaux de Paris ยท Tests: AD + SHR + active LT and extended-release melatonin 2mg, AD + SHR + active LT and placebo melatonin, AD + SHR + placeboโ€ฆ Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients NCT06372964Phase 368 sites๐Ÿ“ Dothan๐Ÿ“ Little Rock๐Ÿ“ Anaheim Intra-Cellular Therapies, Inc. ยท Tests: Lumateperone, Placebo The Effect of PROSE or Scleral Lenses on Mental Health NCT07195721n/a1 site๐Ÿ“ Needham Boston Sight Singula Phase 0.1 Primary Care Pilot NCT07834684n/a2 sites๐Ÿ“ Brentwood๐Ÿ“ Mount Kisco Singula Health, Inc. Feasibility, Safety, and Preliminary Clinical Efficacy of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study NCT07185438NA1 site๐Ÿ“ Chongqing First Affiliated Hospital of Chongqing Medical University ยท Tests: Experimental target rTMS treatment, Conventional target rTMS treatment, Sham stimulation treatment A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) NCT07196501Phase 361 sites๐Ÿ“ Oceanside๐Ÿ“ Orange๐Ÿ“ San Jose Neurocrine Biosciences ยท Tests: Osavampator, Placebo Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder NCT07703722Phase 33 sites๐Ÿ“ Islamabad๐Ÿ“ Peshawar๐Ÿ“ Peshawar Khyber Medical University Peshawar ยท Tests: Psilocybin, Structured Integrated Reframing Therapy (SIRT), Selective Serotonin Reuptake Inhibitor (SSRI) Taking Action for College Students NCT06700902NA1 site๐Ÿ“ Philadelphia Temple University ยท Tests: Taking Action Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression NCT06610305Phase 41 site๐Ÿ“ Chapel Hill University of North Carolina, Chapel Hill ยท Tests: Transdermal estradiol, Progesterone, Transdermal placebo patch, placebo capsule Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation NCT06763081n/a2 sites๐Ÿ“ Winnipeg๐Ÿ“ Winnipeg University of Manitoba ยท Tests: Not applicable- observational study Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine NCT07500714NA1 site๐Ÿ“ Taichung National Science and Technology Council, Taiwan ยท Tests: Internet Cognitive-Behavioral Therapy, Sham treatment Closed-Loop Deep Brain Stimulation for Major Depression NCT04004169NA1 site๐Ÿ“ San Francisco Andrew Krystal ยท Tests: Stimulation-ON, Stimulation-OFF, Stimulation-ON Active Control Impact of Depression on Thermoregulation NCT06805851n/a1 site๐Ÿ“ University Park Penn State University The Efficacy And Safety Of Mitizodone Phosphate Tablets In The Treatment of Patient With Major Depressive Disorder NCT04984512Phase 2, Phase 31 site๐Ÿ“ Dongguan Sunshine Lake Pharma Co., Ltd. ยท Tests: Mitizodone Phosphate tablets, Placebo-matching tablets One-Day cTBS Over the Precuneus NCT07758010NA1 site๐Ÿ“ Belmont Mclean Hospital ยท Tests: Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst stiโ€ฆ Home tDCS for the Treatment of Major Depression. NCT07510880NA3 sites๐Ÿ“ L'Hospitalet de Llobregat๐Ÿ“ Matarรณ๐Ÿ“ Sabadell Ionclinics & Deionic SL ยท Tests: Accelerated protocol of home Transcranial direct current stimulation, Conventional protocol of home Transcranial directโ€ฆ The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects NCT05786066Phase 21 site๐Ÿ“ West Haven Yale University ยท Tests: Perampanel 6 MG, Ketamine, Placebo An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies. NCT07373470NA1 site๐Ÿ“ Pittsburgh University of Pittsburgh ยท Tests: Comprehensive medication management with PGx testing results, Usual Care
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