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Trial Match

Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Malignant Glioma of Brain

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion NCT04655404EARLY Phase 121 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Larotrectinib, Larotrectinib surgical NK Cell Therapy for Malignant Solid Brain Tumors NCT07552233NA4 sites๐Ÿ“ Beijing๐Ÿ“ Qinhuangdao๐Ÿ“ Zhengzhou Peking University Third Hospital ยท Tests: Autologous NK cells rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG NCT04943848Phase 13 sites๐Ÿ“ Orange๐Ÿ“ Chicago๐Ÿ“ Boston Ann & Robert H Lurie Children's Hospital of Chicago ยท Tests: rHSC-DIPGVax, Balstilimab, Zalifrelimab Evaluation of Clinical Efficacy and Safety of Specific Mode Electroacupuncture Stimulation for Paclitaxel Across BBB Delivery in Patients With Postoperative Recurrence of Malignant Glioma: A Single-arm Trial NCT06818331Phase 21 site๐Ÿ“ China The Third Affiliated hospital of Zhejiang Chinese Medical Uโ€ฆ ยท Tests: SMES+PTX, Paclitaxel, Specific mode electroacupuncture stimulation Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China NCT05672043n/a1 site๐Ÿ“ Beijing Beijing Tiantan Hospital A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925Phase 13 sites๐Ÿ“ Tampa๐Ÿ“ Chicago๐Ÿ“ New York Tetragon Biosciences Ltd ยท Tests: GLIX1 Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial NCT06132685Phase 21 site๐Ÿ“ Atlanta Emory University ยท Tests: Biospecimen Collection, Computed Tomography, Dexamethasone, Magnetic Resonance Imaging, Questionnaire Administration Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion NCT06333899EARLY Phase 118 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Lorlatinib, Lorlatinib with chemotherapy1, Lorlatinib with chemotherapy 2, Lorlatinib post Radiation C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B) NCT04099797Phase 11 site๐Ÿ“ Houston Baylor College of Medicine ยท Tests: C7R-GD2.CART cells (IV and ICV infusion), C7R-GD2.CART cells (IV and ICV infusion) 000860: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations NCT05588141Phase 1, Phase 22 sites๐Ÿ“ Jacksonville๐Ÿ“ Bethesda National Cancer Institute (NCI) ยท Tests: Zotiraciclib Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients NCT03849430n/a1 site๐Ÿ“ Leuven Universitaire Ziekenhuizen KU Leuven Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188Phase 1, Phase 21 site๐Ÿ“ Bethesda National Institute of Neurological Disorders and Stroke (NIโ€ฆ ยท Tests: LMP744, Conventional Surgery or Biopsy Chronic CED of TPT for Recurrent Malignant Glioma NCT06666712Phase 11 site๐Ÿ“ New York Jeffrey N. Bruce ยท Tests: Topotecan Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases NCT06888817Phase 36 sites๐Ÿ“ Amsterdam๐Ÿ“ Amsterdam๐Ÿ“ Leiden The Netherlands Cancer Institute ยท Tests: Bevacizumab, Dexamethasone HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors NCT03911388Phase 13 sites๐Ÿ“ Birmingham๐Ÿ“ St Louis๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: G207 The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201) NCT06118723n/a8 sites๐Ÿ“ San Francisco๐Ÿ“ Boston๐Ÿ“ Leuven Jasper Gerritsen ยท Tests: Supramaximal resection, Maximal safe resection ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas NCT06838676Phase 220 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Miami Nationwide Children's Hospital ยท Tests: ACT001 Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection NCT06018363Phase 1, Phase 21 site๐Ÿ“ Suzhou Dushu Lake Hospital Affiliated to Soochow University ยท Tests: Allogenic B7-H3 CAR-ฮณฮดT cell(QH104) Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions NCT04047264NA1 site๐Ÿ“ Rochester Mayo Clinic ยท Tests: Microdialysis, Magnetic Resonance Imaging, Computed Tomography Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) NCT07210632EARLY Phase 11 site๐Ÿ“ Nashville Eben Rosenthal ยท Tests: Nivolumab, Nivolumab-IRDye800 Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) NCT06193759Phase 11 site๐Ÿ“ Washington D.C. Children's National Research Institute ยท Tests: Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalizedโ€ฆ Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors NCT06914479Phase 11 site๐Ÿ“ Ann Arbor University of Michigan Rogel Cancer Center ยท Tests: Ad-hCMV-Flt3L, Ad-hCMV-TK, Biospecimen Collection, Magnetic Resonance Imaging, Survey Administration Safety Study of the Repeated Opening of the Blood-brain Barrier With the SonoCloudยฎ Device to Treat Malignant Brain Tumors in Pediatric Patients NCT05293197Phase 13 sites๐Ÿ“ Paris๐Ÿ“ Paris๐Ÿ“ Villejuif Assistance Publique - Hรดpitaux de Paris ยท Tests: SonoCloudยฎ (9 transducers) Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG NCT05555550EARLY Phase 11 site๐Ÿ“ Philadelphia Children's Hospital of Philadelphia ยท Tests: 18F-Fluciclovine Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant NCT05843253Phase 220 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Chicago Nationwide Children's Hospital ยท Tests: Ribociclib, Everolimus, Temozolomide (TMZ) Window of Opportunity Study of DSP-0390 in Gliomas NCT06636162EARLY Phase 11 site๐Ÿ“ St Louis Washington University School of Medicine ยท Tests: DSP-0390 Sitagliptin in Recurrent/Progressive Grade 4 Glioma NCT07541781Phase 11 site๐Ÿ“ Iowa City Kailin Yang, MD, PhD ยท Tests: Sitagliptin, Bevacizumab SeOuL cOhort of Brain Tumor MONitoring Study (SOLOMON) NCT05254197n/a1 site๐Ÿ“ Seoul Seoul National University Hospital The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302) NCT06283927n/a8 sites๐Ÿ“ San Francisco๐Ÿ“ Boston๐Ÿ“ Leuven Jasper Gerritsen ยท Tests: Re-resection, Temozolomide, Lomustine, Re-irradiation, Experimental therapy Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis NCT06047379Phase 1, Phase 28 sites๐Ÿ“ Beverly Hills๐Ÿ“ Glendale๐Ÿ“ Los Angeles Neonc Technologies, Inc. ยท Tests: NEO212 Oral Capsule, Ipilimumab, Pembrolizumab, Nivolumab, Regorafenib
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