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Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Metastatic Esophageal Squamous Cell Carcinoma

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma NCT03556228Phase 1, Phase 215 sites๐Ÿ“ Santa Rosa๐Ÿ“ Hartford๐Ÿ“ Washington D.C. VM Oncology, LLC ยท Tests: VMD-928 100 mg Tablet, VMD-928 Tablet and Pembrolizumab (200 mg) Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) NCT06780111Phase 1, Phase 252 sites๐Ÿ“ Pittsburgh๐Ÿ“ Natal๐Ÿ“ Porto Alegre Merck Sharp & Dohme LLC ยท Tests: Pembrolizumab, I-DXd, Leucovorin, Levoleucovorin, 5-Fluorouracil (5-FU) Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers NCT04221893NA2 sites๐Ÿ“ San Francisco๐Ÿ“ Walnut Creek University of California, San Francisco ยท Tests: Radiation Therapy (RT) Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors NCT06535607Phase 298 sites๐Ÿ“ Los Angeles๐Ÿ“ Baltimore๐Ÿ“ New York AstraZeneca ยท Tests: Volrustomig, Cisplatin, Carboplatin, Paclitaxel, 5-FU A Study to Investigate ALE.P02 as a Monotherapy or in Combination With Pembrolizumab in Adult Patients With Selected CLDN1+ Solid Tumors NCT06747585Phase 1, Phase 241 sites๐Ÿ“ Scottsdale๐Ÿ“ Fullerton๐Ÿ“ Los Angeles Alentis Therapeutics AG ยท Tests: ALE.P02, Pembrolizumab Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors NCT06975410Phase 1, Phase 24 sites๐Ÿ“ Seoul๐Ÿ“ Seoul๐Ÿ“ Seoul Yuhan Corporation ยท Tests: YH32364 Sintilimab and Chemotherapy Sequential Radiotherapy in Advanced Esophageal Cancer NCT06138028Phase 2, Phase 32 sites๐Ÿ“ Qingdao๐Ÿ“ Qingdao Qingdao Central Hospital ยท Tests: TP regimen (cis-platinum ; Tocetaxel ) combined with PD-1 inhibitors๏ผˆSintilimab๏ผ‰ A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F) NCT07405151Phase 1, Phase 232 sites๐Ÿ“ Pittsburgh๐Ÿ“ Natal๐Ÿ“ Porto Alegre Merck Sharp & Dohme LLC ยท Tests: I-DXd, Rescue Medication Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer NCT04415853Phase 31 site๐Ÿ“ Beijing Sunshine Lake Pharma Co., Ltd. ยท Tests: Lerotinib, Irinotecan/Tegafur Sacituzumab Govitecan Combined With Tislelizumab for Locally Advanced/Metastatic Esophageal Cancer NCT07811752Phase 22 sites๐Ÿ“ Shanghai๐Ÿ“ Shanghai Shanghai Chest Hospital ยท Tests: Sacituzumab Tirumotecan (SKB264) plus Tislelizumab A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors NCT06465069Phase 139 sites๐Ÿ“ Duarte๐Ÿ“ La Jolla๐Ÿ“ Los Angeles Eli Lilly and Company ยท Tests: LY4052031, Pembrolizumab A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors NCT07887971Phase 11 site๐Ÿ“ Miami Aktis Oncology, Inc. ยท Tests: [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging) Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rฮฑ Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer NCT05267626Phase 1, Phase 217 sites๐Ÿ“ Miami๐Ÿ“ Grand Rapids๐Ÿ“ Minneapolis Aulos Bioscience, Inc. ยท Tests: AU-007, Aldesleukin, Avelumab, Nivolumab A Study of SH009 Injection in Patients With Advanced Solid Tumors. NCT07390838Phase 11 site๐Ÿ“ Shanghai Nanjing Sanhome Pharmaceutical, Co., Ltd. ยท Tests: SH009 KC1036 in Combination With PD-1 Antibody and Platinum-based Chemotherapy for First-line Advanced Esophageal Cancer NCT07481058Phase 21 site๐Ÿ“ Beijing Beijing Konruns Pharmaceutical Co., Ltd. ยท Tests: KC1036, Toripalimab, Paclitaxel, Cisplatin, KC1036 Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program NCT06265285Phase 21 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Home Health Encounter, Nivolumab, Patient Monitoring, Questionnaire Administration Study of XB010 in Subjects With Solid Tumors NCT06545331Phase 120 sites๐Ÿ“ Irvine๐Ÿ“ Los Angeles๐Ÿ“ Washington D.C. Exelixis ยท Tests: XB010, Pembrolizumab Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic NCT07807345Phase 16 sites๐Ÿ“ Orlando๐Ÿ“ Boston๐Ÿ“ Oklahoma City Sutro Biopharma, Inc. ยท Tests: STRO-006, Pembrolizumab Ivonescimab Plus Short-Course Hypofractionated Radiotherapy as Second-Line Therapy for Esophageal Squamous Cell Carcinoma NCT07188103Phase 21 site๐Ÿ“ Hefei Anhui Provincial Hospital ยท Tests: Ivonescimab+Radiotherapy A Phase II Clinical Study to Evaluate HLX43 in Patients With Recurrent/Metastatic ESCC Failed or Intolerance to Standard Therapy NCT06769113Phase 21 site๐Ÿ“ Jinan Shanghai Henlius Biotech ยท Tests: HLX43 177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors NCT07189871Phase 1, Phase 25 sites๐Ÿ“ Dothan๐Ÿ“ Grand Rapids๐Ÿ“ Omaha Radiopharm Theranostics, Ltd ยท Tests: 177Lu-BetaBart, BetaBart + unlabeled BetaBart A Study of MGC026 in Participants With Advanced Solid Tumors NCT06242470Phase 112 sites๐Ÿ“ Los Angeles๐Ÿ“ Grand Rapids๐Ÿ“ Lake Success MacroGenics ยท Tests: MGC026 Dose Escalation, MGC026 Dose for Expansion, Pembrollizumab, vobramitamab tavatecan The Efficacy and Safety of Iparomlimab and Tuvonralimab Injection Combined With Chemotherapy as the First-line Treatment for Esophageal Squamous Cell Carcinoma NCT07290010Phase 21 site๐Ÿ“ Shijiazhuang Hebei Medical University Fourth Hospital ยท Tests: Iparomlimab and Tuvonralimab combined with chemotherapy A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors NCT06657144Phase 130 sites๐Ÿ“ Tucson๐Ÿ“ Duarte๐Ÿ“ Aurora Coherus Oncology, Inc. ยท Tests: CHS-114, Toripalimab, 5 Fluorouracil, Cisplatin Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis NCT06047379Phase 1, Phase 28 sites๐Ÿ“ Beverly Hills๐Ÿ“ Glendale๐Ÿ“ Los Angeles Neonc Technologies, Inc. ยท Tests: NEO212 Oral Capsule, Ipilimumab, Pembrolizumab, Nivolumab, Regorafenib QLC5508 vs. Chemotherapy in Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma NCT07463573Phase 31 site๐Ÿ“ Beijing Qilu Pharmaceutical Co., Ltd. ยท Tests: QLC5508, Investigator's Choice of Chemotherapy (docetaxel, paclitaxel, or Irinotecan Hydrochloride) A Clinical Study of KK2260 in Patients With Advanced or Metastatic Solid Tumors NCT06248411Phase 114 sites๐Ÿ“ Nagoya๐Ÿ“ Kashiwa๐Ÿ“ Matsuyama Kyowa Kirin Co., Ltd. ยท Tests: KK2260, KK2260 A Trial of the Combination of Afatinib and Palbociclib in Previously Treated Advanced Esophageal Squamous Cell Carcinoma NCT06753747Phase 1, Phase 21 site๐Ÿ“ Chengdu West China Hospital ยท Tests: Palbociclib, Afatinib(30mg), Afatinib(40mg), Afatinib(RP2D) A Study of IDP-001 in Advanced or Metastatic Solid Tumors NCT07602842Phase 1, Phase 26 sites๐Ÿ“ Los Angeles๐Ÿ“ Sarasota๐Ÿ“ Indianapolis InduPro, Inc. ยท Tests: IDP-001 Pilot Study of [68Ga]Ga-ABY-025 Imaging in Patients Undergoing Treatment With HER2-targeted Therapy NCT06828588EARLY Phase 11 site๐Ÿ“ Nashville Vanderbilt-Ingram Cancer Center ยท Tests: [68Ga]Ga-ABY-025
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