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30 recruiting trials

for Metastatic Head and Neck Squamous Cell Carcinoma

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma NCT03556228Phase 1, Phase 215 sites๐Ÿ“ Santa Rosa๐Ÿ“ Hartford๐Ÿ“ Washington D.C. VM Oncology, LLC ยท Tests: VMD-928 100 mg Tablet, VMD-928 Tablet and Pembrolizumab (200 mg) Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06) NCT06780111Phase 1, Phase 252 sites๐Ÿ“ Pittsburgh๐Ÿ“ Natal๐Ÿ“ Porto Alegre Merck Sharp & Dohme LLC ยท Tests: Pembrolizumab, I-DXd, Leucovorin, Levoleucovorin, 5-Fluorouracil (5-FU) Effect of Postbiotics on Microbiota and Systemic Immunomodulation of Pembrolizumab as First-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (RM HNSCC) NCT07485296Phase 21 site๐Ÿ“ Rozzano Gruppo Oncologico del Nord-Ovest ยท Tests: Postbiotix-HLAโ„ข is a food supplement based on fermented FOS from Lactobacillus paracasei CNCM I-5220 postbiotic., placeโ€ฆ Study on the Efficacy of Treatment by Radiotherapy and Pembrolizumab in Newly Diagnosed Metastatic Head & Neck Cancers NCT04747054Phase 326 sites๐Ÿ“ Avignon๐Ÿ“ Besanรงon๐Ÿ“ Bordeaux UNICANCER ยท Tests: Pembrolizumab, Loco-regional radiotherapy, Chemotherapy Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus NCT05918510n/a1 site๐Ÿ“ Rome Regina Elena Cancer Institute ยท Tests: Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx Establishment of a Microfluidic Based Liquid Biopsy Platform for Recurrent/Metastatic Head and Neck Cancers Prognostication Using NK Cell IFN-ฮณ Expression and CTM Correlation With DS-SACA Chip NCT06678724n/a1 site๐Ÿ“ Zhubei National Taiwan University Hospital AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy NCT06494995Phase 21 site๐Ÿ“ Shanghai Fudan University ยท Tests: Cadonilimab, Low-dose radiotherapy, SBRT, Capecitabine Surufatinib Combined with Envolizumab As Second-line Treatment for Recurrent/Metastatic HNSCC NCT06876844Phase 21 site๐Ÿ“ Shanghai Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaโ€ฆ ยท Tests: combination of Surufatinib and Envolizumab A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02) NCT06330064Phase 1, Phase 2120 sites๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles๐Ÿ“ Whittier Daiichi Sankyo ยท Tests: Ifinatamab deruxtecan Radiation Therapy for the Treatment of Metastatic Gastrointestinal Cancers NCT04221893NA2 sites๐Ÿ“ San Francisco๐Ÿ“ Walnut Creek University of California, San Francisco ยท Tests: Radiation Therapy (RT) A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY) NCT05576974Phase 21 site๐Ÿ“ Dallas University of Texas Southwestern Medical Center ยท Tests: Pegsitacianine Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer NCT07667400Phase 1, Phase 21 site๐Ÿ“ Bethesda National Cancer Institute (NCI) ยท Tests: SX-682, DTX H101 Plus TACE for r/m HNSCC NCT07398664Phase 21 site๐Ÿ“ Chengdu West China Hospital ยท Tests: H101, TACE A Phase 3 Study of AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) NCT06601335Phase 32 sites๐Ÿ“ Wuhan๐Ÿ“ Chengdu Akeso ยท Tests: AK117 in combination with AK112, Placebo in combination with Pembrolizumab SYS6010 Combined With Enlonstobart In Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma NCT07254585Phase 21 site๐Ÿ“ Shanghai CSPC Megalith Biopharmaceutical Co.,Ltd. ยท Tests: SYS6010 injection, Enlonstobart injection, Pembrolizumab injection Using a 3D Culture Model for Circulating Tumor Cells Combined With Molecular Bioassays in Patients With HNSCC Cancer NCT06755762n/a1 site๐Ÿ“ Taoyuan Chang Gung Memorial Hospital ยท Tests: Organoid 3D culture Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors NCT06535607Phase 298 sites๐Ÿ“ Los Angeles๐Ÿ“ Baltimore๐Ÿ“ New York AstraZeneca ยท Tests: Volrustomig, Cisplatin, Carboplatin, Paclitaxel, 5-FU A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors NCT07115043Phase 1, Phase 213 sites๐Ÿ“ Grand Rapids๐Ÿ“ St Louis๐Ÿ“ Pittsburgh AstraZeneca ยท Tests: AZD6750, rilvegostomig A Study to Investigate ALE.P02 as a Monotherapy or in Combination With Pembrolizumab in Adult Patients With Selected CLDN1+ Solid Tumors NCT06747585Phase 1, Phase 241 sites๐Ÿ“ Scottsdale๐Ÿ“ Fullerton๐Ÿ“ Los Angeles Alentis Therapeutics AG ยท Tests: ALE.P02, Pembrolizumab TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer NCT06868433Phase 12 sites๐Ÿ“ Atlanta๐Ÿ“ Atlanta Emory University ยท Tests: Autologous Tumor Membrane Vesicles Vaccine, Biospecimen Collection, Computed Tomography, Echocardiography, Magnetic Resโ€ฆ FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC NCT06788990Phase 2, Phase 3231 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ La Jolla Bicara Therapeutics ยท Tests: Ficerafusp alfa, Pembrolizumab (KEYTRUDAยฎ), Placebo A Study of NX-1607 in Adults With Advanced Malignancies NCT05107674Phase 117 sites๐Ÿ“ Duarte๐Ÿ“ Los Angeles๐Ÿ“ San Francisco Nurix Therapeutics, Inc. ยท Tests: NX-1607, Paclitaxel The Management of Metastatic Neck Nodes in N2/3 Hypopharyngeal Squamous Cell Carcinoma NCT05494190NA3 sites๐Ÿ“ Harbin๐Ÿ“ Jinan๐Ÿ“ Shanghai Eye & ENT Hospital of Fudan University ยท Tests: Docetaxel, Cisplatin, Capecitabine, Concomitant chemoradiotherapy, Surgery Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors NCT07584499Phase 11 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Becotatug Vedotin Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors NCT06975410Phase 1, Phase 24 sites๐Ÿ“ Seoul๐Ÿ“ Seoul๐Ÿ“ Seoul Yuhan Corporation ยท Tests: YH32364 Study of TPEx Followed by a Maintenance With Avelumab and Cetuximab in First Line Recurrent or Metastatic Squamous Cell Carcinoma of the H&N NCT06640725Phase 21 site๐Ÿ“ Vandล“uvre-lรจs-Nancy Groupe Oncologie Radiotherapie Tete et Cou ยท Tests: Avelumab administration at 10mg/kg, Cetuximab (Erbitux) A Phase II Clinical Study to Evaluate HLX43 in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma NCT06857279Phase 22 sites๐Ÿ“ Jinan๐Ÿ“ Shanghai Shanghai Henlius Biotech ยท Tests: HLX43 DOSE 1, HLX43 DOSE 2, HLX43 DOSE 3, HLX43 DOSE 2 + HLX10, HLX43 DOSE 3 + HLX10 Sintilimab and Chemotherapy Sequential Radiotherapy in Advanced Esophageal Cancer NCT06138028Phase 2, Phase 32 sites๐Ÿ“ Qingdao๐Ÿ“ Qingdao Qingdao Central Hospital ยท Tests: TP regimen (cis-platinum ; Tocetaxel ) combined with PD-1 inhibitors๏ผˆSintilimab๏ผ‰ A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F) NCT07405151Phase 1, Phase 232 sites๐Ÿ“ Pittsburgh๐Ÿ“ Natal๐Ÿ“ Porto Alegre Merck Sharp & Dohme LLC ยท Tests: I-DXd, Rescue Medication Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer NCT04415853Phase 31 site๐Ÿ“ Beijing Sunshine Lake Pharma Co., Ltd. ยท Tests: Lerotinib, Irinotecan/Tegafur
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