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Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Muscle Invasive Bladder Urothelial Carcinoma

Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE) NCT06396533n/a2 sites📍 Omaha📍 Philadelphia Fox Chase Cancer Center Tumor-informed ctDNA in Muscle-invasive Bladder Cancer for Evaluation of Residual/Recurrent Disease - the TiMBER Trial NCT07726602n/a1 site📍 Portland OHSU Knight Cancer Institute · Tests: Non-Interventional Study EV + Toripalimab vs GC as Neoadjuvant Therapy in Locally Advanced/High-Risk MIBC NCT07647289Phase 21 site📍 Beijing Peking University Third Hospital · Tests: enfortumab vedotin (EV), Toripalimab, Gemcitabine (Chemotherapy), Cisplatin Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study NCT05987241Phase 2, Phase 3505 sites📍 Phoenix📍 Phoenix📍 Tucson National Cancer Institute (NCI) · Tests: Biospecimen Collection, cfDNA or ctDNA Measurement, Computed Tomography, Cystoscopy, Magnetic Resonance Imaging Specimen Collection for Validation of UroAmp: A Next Generation Sequencing Platform for Detection and Surveillance of Bladder Cancer NCT07673016n/a23 sites📍 Oceanside📍 San Diego📍 San Jose Convergent Genomics, Inc. Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy NCT07234968NA2 sites📍 Philadelphia📍 Philadelphia Thomas Jefferson University · Tests: Ureteral Stent Placement, No Ureteral Stent, Indocyanine Green with Fluorescence Imaging Home-Based Physical Activity Program With Digital App Versus Health Education Group for Improving Physical Activity Among Patients With Non-muscle Invasive Bladder Cancer, The EMPOWER Trial NCT07302230NA1 site📍 Seattle University of Washington · Tests: Internet-Based Intervention, Best Practice, Internet-Based Intervention, Exercise Intervention, Health Telemonitoring Adaptive RADiation Therapy With Concurrent Sacituzumab Govitecan (SG) for Muscle Invasive Bladder Cancer NCT05833867Phase 11 site📍 Cleveland Shilpa Gupta, MD · Tests: Sacituzumab govitecan, Adaptive Radiotherapy Modular Trial of sEphB4-HSA in EphrinB2-High Solid Tumors NCT06493552Phase 2, Phase 31 site📍 Santa Monica Vasgene Therapeutics, Inc · Tests: SEphB4-HSA, Pembrolizumab, Gemcitabine, Cisplatin, Enfortumab vedotin Validation of a Circulating Tumor DNA Blood Test in Muscle-Invasive Bladder and Upper Tract Urothelial Cancer NCT07756437n/a1 site📍 Ghent AZ Sint-Lucas Gent Is Prolonged Systemic Immunotherapy Necessary After Achieving Tumor-free Status in Patients With Extensive Transurethrally Unresectable Very-high-risk NMIBC? NCT07625527Phase 24 sites📍 Tianjin📍 Tianjin📍 Tianjin Tianjin Medical University Second Hospital · Tests: Active Surveillance, PD-1/PD-L1 Inhibitor-Based Systemic Immunotherapy Intravesical GEM/DOCE for HR BCG-Unresponsive NMIBC NCT07322263Phase 21 site📍 Iowa City Michael A. O'Donnell · Tests: Intravesical Gemcitabine and Docetaxel Treatment Expedition With MRI Processing and Optimization for Muscle Invasive Bladder Cancer NCT07067749Phase 31 site📍 Rome University of Rome Tor Vergata · Tests: multiparametric magnetic resonance imaging (mpMRI) of the bladder, Transurethral resection of bladder tumour (TURBt), C… Vesical Imaging-Reporting and Data System (VI-RADS) Followed by Photodynamic Trans-urethral Resection of Bladder Tumours (PDD-TURBT) to Avoid Secondary Resections (Re-TURBT) in Non-Muscle Invasive Bladder Cancers (NMIBCs) NCT05962541Phase 41 site📍 Rome University of Roma La Sapienza · Tests: PDD-TURBT with hexaminolevulinate (Hexvix®), Power Led Saphira (TM) Prospective Sample Collection for Cancer of Bladder NCT03973671n/a1 site📍 Leuven Universitaire Ziekenhuizen KU Leuven A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer NCT06503614Phase 25 sites📍 San Francisco📍 Tampa📍 New Brunswick John Sfakianos · Tests: Durvalumab, Monalizumab An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC NCT07720284Phase 3160 sites📍 Hot Springs📍 Little Rock📍 Little Rock AstraZeneca · Tests: Dato-DXd, Rilvegostomig, Durvalumab, Nivolumab, Pembrolizumab Sun Yat-Sen Treatment Strategy for Enhancing Response in Muscle-invasive Bladder Cancer NCT07717242Phase 21 site📍 Guangzhou Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Tests: Disitamab vedotin, Toripalimab, Sitagliptin, Zeprumetostat, Tafolecimab Home Intravenous Fluid Infusion After Undergoing Radical Cystectomy NCT07225205NA2 sites📍 Baltimore📍 Baltimore Johns Hopkins University · Tests: Intravenous fluids, ERAS Perioperative Systemic Therapies in Muscle-Invasive Bladder Cancer (GUARDIANS) NCT07855926n/a1 site📍 Munich LMU Klinikum · Tests: Perioperative Systemic Therapy Registry NEO-BLAST: Neoadjuvant Therapy for Bladder Cancer Followed by Active Surveillance vs Treatment NCT06537154Phase 2, Phase 31 site📍 Vancouver Peter Black · Tests: Active Surveillance, Control arm - Definitive bladder treatment DV+BCG in HER2-Expressing, BCG-Naïve High-Risk NMIBC NCT07207824Phase 31 site📍 Shanghai Fudan University · Tests: Active Comparator: BCG induction and maintenance, DV + BCG induction and maintenance Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients NCT03945162Phase 216 sites📍 Chicago📍 Greenwood📍 Syracuse Theralase® Technologies Inc. · Tests: Ruvidar® (TLD-1433) bladder infusion and PDT LCS103 Herbal Formula for Secondary Prevention of Non-Muscle Invasive Urothelial Carcinoma of the Bladder NCT07728474NA1 site📍 Haifa LifeBiotic Medical Research Ltd. · Tests: LCS103 Study on the Occurrence of Possible Relapses and on the Quality of Life in Patients Who Underwent TURBK. NCT06167356n/a1 site📍 Milan IRCCS San Raffaele Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy NCT06263153Phase 23 sites📍 Ann Arbor📍 Cleveland📍 Columbus Yuanquan Yang · Tests: Biospecimen Collection, Computed Tomography, Durvalumab, Futibatinib, Magnetic Resonance Imaging Efficacy and Safety of Intravesical TARA-002 Compared With Investigator's Choice of Intravesical Chemotherapy in Participants With BCG-naïve High-grade Non-muscle Invasive Bladder Cancer NCT07480356Phase 311 sites📍 Queen Creek📍 Little Rock📍 Bakersfield Protara Therapeutics · Tests: TARA-002, Investigator's Choice of Intravesical Chemotherapy Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309) NCT07566156Phase 329 sites📍 Little Rock📍 Santa Barbara📍 Aurora Astellas Pharma Global Development, Inc. · Tests: Enfortumab vedotin, Conventional Radiotherapy, Hypofractionated Radiotherapy, Cisplatin, Fluorouracil Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial NCT07061964Phase 2182 sites📍 Birmingham📍 Gilbert📍 Phoenix National Cancer Institute (NCI) · Tests: Biospecimen Collection, Computed Tomography, Cystoscopy, Magnetic Resonance Imaging, Pembrolizumab Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT) NCT06571708Phase 21 site📍 New York Columbia University · Tests: Gemcitabine, Cisplatin, Cemiplimab, Fianlimab
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