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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Neurofibromatosis 1

HL-085 in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas NCT05331105Phase 21 site📍 Shanghai Shanghai Kechow Pharma, Inc. · Tests: HL-085 Evaluation of TQ-B3234 Capsules in Patients With Symptomatic, Non-Surgical Type 1 Neurofibromatosis-Associated Plexiform Neurofibromas NCT07407803Phase 329 sites📍 Hefei📍 Beijing📍 Beijing Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Tests: TQ-B3234 capsules, TQ-B3234 placebo Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas NCT05253131Phase 21 site📍 Birmingham University of Alabama at Birmingham · Tests: Selumetinib + ZEN-3694 ± Durvalumab Glioma Developmental and HyperActive Ras Tumor (DHART) Board NCT05489783n/a7 sites📍 Basking Ridge📍 Middletown📍 Montvale Memorial Sloan Kettering Cancer Center Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1 NCT07102394Phase 11 site📍 Baltimore Johns Hopkins University · Tests: Imlygic Mirdametinib in Patients With Advanced NF1-mutant Melanoma NCT07237100Phase 21 site📍 San Francisco Kevin Kim, MD · Tests: Mirdametinib Study of Cabozantinib With Selumetinib for Plexiform Neurofibromas NCT06502171Phase 18 sites📍 Birmingham📍 Los Angeles📍 Washington D.C. Girish Dhall, MD · Tests: Cabozantinib Oral Tablet, Selumetinib Oral Capsule A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma NCT04166409Phase 3132 sites📍 Birmingham📍 Mesa📍 Phoenix National Cancer Institute (NCI) · Tests: Biospecimen Collection, Carboplatin, Echocardiography Test, Magnetic Resonance Imaging, Questionnaire Administration A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1) NCT06507748NA2 sites📍 Washington D.C.📍 Bethesda National Cancer Institute (NCI) · Tests: AlgometRx Nociometer(R) A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1 NCT06541847Phase 214 sites📍 Birmingham📍 Los Angeles📍 Palo Alto Healx Limited · Tests: HLX-1502 GROWing Up With Rare GENEtic Syndromes NCT04463316n/a1 site📍 Rotterdam dr. Laura C. G. de Graaff-Herder · Tests: Retrospective file studies Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy NCT05180825Phase 225 sites📍 Amiens📍 Angers📍 Besançon University Hospital, Strasbourg, France · Tests: Trametinib, Vinblastine Observational Study of the Real-world Effectiveness and Safety of Selumetinib Treating Adult Patients With Neurofibromatosis Type 1 (NF1) Who Have Symptomatic, Inoperable Plexiform Neurofibroma (PN) NCT07888517n/a26 sites📍 Beijing📍 Changchun📍 Changsha AstraZeneca FARD (RaDiCo Cohort) (RaDiCo-FARD) NCT05954416n/a15 sites📍 Bobigny📍 Bordeaux📍 Bordeaux Institut National de la Santé Et de la Recherche Médicale, … RASopathy Biorepository NCT04395495n/a1 site📍 Cincinnati Children's Hospital Medical Center, Cincinnati Familial Investigations of Childhood Cancer Predisposition NCT03050268n/a1 site📍 Memphis St. Jude Children's Research Hospital PAS-004 in Patients With Advanced Solid Tumors NCT06299839Phase 15 sites📍 San Antonio📍 Fairfax📍 Sofia Pasithea Therapeutics Corp. · Tests: PAS-004 Capsules, PAS-004 Tablets Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST) NCT06222203n/a1 site📍 Bethesda National Cancer Institute (NCI) MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies NCT05735717Phase 21 site📍 Minneapolis Masonic Cancer Center, University of Minnesota · Tests: Fludarabine, Busulfan, Melphalan, Rituximab, Levetiracetam Real-World Treatment Study of Koselugo (Selumetinib) NCT06360406n/a12 sites📍 Busan📍 Chungcheongbuk-do📍 Daejeon AstraZeneca Tailoring an Online Platform to Promote Evidence-Based Care for Adults With Neurofibromatosis 1 and Low Health Literacy NCT07233408NA1 site📍 Boston Massachusetts General Hospital · Tests: NF1 Educational Videos, Peer Navigator, Letters about NF1 Care Development of Patient-Reported Outcome Measures Assessing Tumor Visibility and Appearance Concerns in Neurofibromatosis Type 1: A Qualitative Study NCT06880991n/a1 site📍 Bethesda National Cancer Institute (NCI) · Tests: Arm 1 Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial NCT05361811NA1 site📍 Bethesda National Cancer Institute (NCI) · Tests: Waitlist, ACT Intervention Cutaneous and Mucosal Manifestations of Neurofribromatosis Type 2 in Children Under 15 NCT03893643n/a1 site📍 Nice Centre Hospitalier Universitaire de Nice · Tests: no intervention Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF). NCT06159166Phase 1, Phase 21 site📍 Baltimore Johns Hopkins University · Tests: Mirdametinib Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders NCT06147414n/a1 site📍 Paris Assistance Publique - Hôpitaux de Paris · Tests: Blood sample Evaluation of Percutaneous Cryotherapy in the Treatment of Plexiform Neurofibromas and Unresectable Neurofibromas in Neurofibromatosis Type 1 NCT05199376NA1 site📍 Lyon Centre Leon Berard · Tests: Cryotherapy Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1 Using Novel Magnetic Resonance Imaging Techniques Paired With Artificial Intelligence NCT04763109NA1 site📍 Los Angeles Nicole Baca · Tests: Whole-body Magnetic Resonance Imaging Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK NCT06666348Phase 1, Phase 210 sites📍 Calgary📍 Edmonton📍 Vancouver St. Justine's Hospital · Tests: Mirdametinib A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia NCT05849662Phase 1, Phase 221 sites📍 Phoenix📍 Los Angeles📍 San Francisco Therapeutic Advances in Childhood Leukemia Consortium · Tests: Trametinib, Azacitidine, Fludarabine, Cytarabine
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