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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Progressive Multiple Sclerosis

Risk of Progressive Multifocal Leukoencephalopathy Among Patients With Multiple Sclerosis Exposed to Zeposia NCT07732907n/a1 site📍 Lawrenceville Bristol-Myers Squibb · Tests: Ozanimod Allogenic Adipose Tissue-derived Mesenchymal Stromal Cells for the Treatment of Primary Progressive Multiple Sclerosis NCT06592703Phase 12 sites📍 Créteil📍 Rennes Rennes University Hospital · Tests: Adipose tissue-derived Mesenchymal Stromal Cells Definition of Autonomic Nervous System Involvement in Patients With Multiple Sclerosis NCT05748015NA2 sites📍 Telese Terme📍 Naples Istituti Clinici Scientifici Maugeri SpA · Tests: quantification of sensory and autonomic small nerve fibers by punch skin biopsy, Cardiovascular Reflexes testing, Admin… A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS) NCT07282574Phase 2114 sites📍 Camperdown📍 Kogarah📍 New Lambton Heights Hoffmann-La Roche · Tests: RO7268489, Ocrelizumab, Placebo Home Based Clinical Management of Interstitial Lung Disease in Systemic Rheumatic Diseases NCT06732674NA1 site📍 Oslo Oslo University Hospital · Tests: A home monitoring strategy with event driven management Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis NCT07477639Phase 1, Phase 28 sites📍 La Jolla📍 Kansas City📍 Rochester Tr1X, Inc. · Tests: TRX319, Bendamustine Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis NCT05964829NA1 site📍 Cleveland Cionic, Inc. · Tests: Cionic Neural Sleeve NS-100, Walking Program REAL-MS: Observational Database Study of AHSCT and MS Therapies NCT07899502n/a3 sites📍 London📍 London📍 London Imperial College London · Tests: Autologous haematopoietic stem cell transplantation (AHSCT), High-efficacy disease-modifying therapy (HE-DMT) A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis NCT07225504Phase 3296 sites📍 Birmingham📍 Phoenix📍 Phoenix Novartis Pharmaceuticals · Tests: Remibrutinib (blinded), Placebo, Remibrutinib (Open label) A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis NCT07067463Phase 376 sites📍 Pheonix📍 Scottsdale📍 West Hollywood Zenas BioPharma (USA), LLC · Tests: Orelabrutinib, Placebo Resistance Training and Corticospinal Excitability in Multiple Sclerosis NCT06374108NA2 sites📍 Aarhus📍 Copenhagen University of Aarhus · Tests: Progressive resistance training Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis (Switzerland) NCT06526364n/a1 site📍 Basel University Hospital, Basel, Switzerland · Tests: All participants will be asked to provide data and samples for collection and analysis. Neurodegenerative Diseases Progression Markers (MARKERS-NDD) NCT06596746n/a1 site📍 Cassino Casa di Cura San Raffaele Cassino · Tests: Observation Phase 1 Study of HBI0101 CAR-T in Refractory B-Cell Autoimmune Diseases NCT07085676Phase 11 site📍 Jerusalem Polina Stepensky · Tests: HBI0101 CART Cladribine vs Placebo for Non-active Progressive Multiple Sclerosis (CLASP-MS). NCT05961644Phase 2, Phase 31 site📍 Warsaw Institute of Psychiatry and Neurology, Warsaw · Tests: Cladribine Subcutaneous Injection, 0.9% Chloride Injection Sodium Effects of Transcranial Static Magnetic Field Stimulation (tSMS) in Progressive Multiple Sclerosis NCT05811013NA1 site📍 Pozzilli Neuromed IRCCS · Tests: Transcranial static magnetic field stimulation (tSMS), Sham Transcranial static magnetic field stimulation (tSMS) Safety and Efficacy of S103 Cells in Progressive/Refractory Multiple Sclerosis NCT07587125Phase 11 site📍 Xi'an Xijing Hospital · Tests: S103 cells MS-ResearchBiomarkerS NCT05204459n/a1 site📍 Los Angeles Cedars-Sinai Medical Center NYSCF Scientific Discovery Biobank NCT06203106n/a1 site📍 New York New York Stem Cell Foundation Research Institute · Tests: Biological Sample Collection Assessment of Synaptic Density in MS NCT04634994EARLY Phase 11 site📍 Boston Brigham and Women's Hospital · Tests: [F-18]SDM-8 An Open-label Study of AZD0120 in Adults With Multiple Sclerosis NCT07224373Phase 119 sites📍 Tucson📍 Aurora📍 Washington D.C. AstraZeneca · Tests: AZD0120 - Regimen 1, AZD0120 - Regimen 2 Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS NCT06390930NA1 site📍 Chicago Shirley Ryan AbilityLab · Tests: Acute Intermittent Hypoxia, Sham Acute Intermittent Hypoxia People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists NCT07207148n/a1 site📍 Chicago Northwestern University · Tests: GLP-1, Ocrelizumab (US) Intermittent Hypoxia in Persons With Multiple Sclerosis NCT06276634NA1 site📍 Chicago Shirley Ryan AbilityLab · Tests: Acute Intermittent Hypoxia, Sham-Acute Intermittent Hypoxia A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis NCT07299019Phase 369 sites📍 Phoenix📍 Scottsdale📍 Fullerton Zenas BioPharma (USA), LLC · Tests: Orelabrutinib, Placebo The Swedish BioFINDER 2 Study NCT03174938NA2 sites📍 Ängelholm📍 Malmö Skane University Hospital · Tests: Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau, Lumipulse (Fujirebio) Abeta42, Tta… Natural History Study of Progressive Multifocal Leukoencephalopathy (PML) NCT01730131n/a1 site📍 Bethesda National Institute of Neurological Disorders and Stroke (NI… SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis NCT03783416Phase 11 site📍 London Queen Mary University of London · Tests: Ixazomib (NINLARO®) capsules / Matching placebo capsules Ultra-High Resolution PET in Aging, Neurodegeneration and Psychotic Disorders NCT07509125NA1 site📍 Leuven Universitaire Ziekenhuizen KU Leuven · Tests: UHR PET/CT scan of the brain with ¹⁸F-FDG, UHR PET/CT scan of the brain with ¹⁸F-PE2I, UHR PET/CT scan of the brain wit… The Effect of Rituximab on Cognitive and Hand Functions in Secondary Progressive Multiple Sclerosis NCT06599307Phase 21 site📍 Giza Cairo University · Tests: Rituximab, Saline (NaCl 0,9 %) (placebo)
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