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30 recruiting trials

for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Effect of Postbiotics on Microbiota and Systemic Immunomodulation of Pembrolizumab as First-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (RM HNSCC) NCT07485296Phase 21 site๐Ÿ“ Rozzano Gruppo Oncologico del Nord-Ovest ยท Tests: Postbiotix-HLAโ„ข is a food supplement based on fermented FOS from Lactobacillus paracasei CNCM I-5220 postbiotic., placeโ€ฆ Establishment of a Microfluidic Based Liquid Biopsy Platform for Recurrent/Metastatic Head and Neck Cancers Prognostication Using NK Cell IFN-ฮณ Expression and CTM Correlation With DS-SACA Chip NCT06678724n/a1 site๐Ÿ“ Zhubei National Taiwan University Hospital AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy NCT06494995Phase 21 site๐Ÿ“ Shanghai Fudan University ยท Tests: Cadonilimab, Low-dose radiotherapy, SBRT, Capecitabine Surufatinib Combined with Envolizumab As Second-line Treatment for Recurrent/Metastatic HNSCC NCT06876844Phase 21 site๐Ÿ“ Shanghai Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaโ€ฆ ยท Tests: combination of Surufatinib and Envolizumab A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02) NCT06330064Phase 1, Phase 2120 sites๐Ÿ“ Los Angeles๐Ÿ“ Los Angeles๐Ÿ“ Whittier Daiichi Sankyo ยท Tests: Ifinatamab deruxtecan Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer NCT07667400Phase 1, Phase 21 site๐Ÿ“ Bethesda National Cancer Institute (NCI) ยท Tests: SX-682, DTX H101 Plus TACE for r/m HNSCC NCT07398664Phase 21 site๐Ÿ“ Chengdu West China Hospital ยท Tests: H101, TACE A Phase 3 Study of AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) NCT06601335Phase 32 sites๐Ÿ“ Wuhan๐Ÿ“ Chengdu Akeso ยท Tests: AK117 in combination with AK112, Placebo in combination with Pembrolizumab SYS6010 Combined With Enlonstobart In Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma NCT07254585Phase 21 site๐Ÿ“ Shanghai CSPC Megalith Biopharmaceutical Co.,Ltd. ยท Tests: SYS6010 injection, Enlonstobart injection, Pembrolizumab injection TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer NCT06868433Phase 12 sites๐Ÿ“ Atlanta๐Ÿ“ Atlanta Emory University ยท Tests: Autologous Tumor Membrane Vesicles Vaccine, Biospecimen Collection, Computed Tomography, Echocardiography, Magnetic Resโ€ฆ FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC NCT06788990Phase 2, Phase 3231 sites๐Ÿ“ Birmingham๐Ÿ“ Phoenix๐Ÿ“ La Jolla Bicara Therapeutics ยท Tests: Ficerafusp alfa, Pembrolizumab (KEYTRUDAยฎ), Placebo Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors NCT07584499Phase 11 site๐Ÿ“ Guangzhou Sun Yat-sen University ยท Tests: Becotatug Vedotin Study of TPEx Followed by a Maintenance With Avelumab and Cetuximab in First Line Recurrent or Metastatic Squamous Cell Carcinoma of the H&N NCT06640725Phase 21 site๐Ÿ“ Vandล“uvre-lรจs-Nancy Groupe Oncologie Radiotherapie Tete et Cou ยท Tests: Avelumab administration at 10mg/kg, Cetuximab (Erbitux) A Phase II Clinical Study to Evaluate HLX43 in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma NCT06857279Phase 22 sites๐Ÿ“ Jinan๐Ÿ“ Shanghai Shanghai Henlius Biotech ยท Tests: HLX43 DOSE 1, HLX43 DOSE 2, HLX43 DOSE 3, HLX43 DOSE 2 + HLX10, HLX43 DOSE 3 + HLX10 Study of Larotinib in Unresectable Advanced or Recurrent Esophageal Cancer NCT04415853Phase 31 site๐Ÿ“ Beijing Sunshine Lake Pharma Co., Ltd. ยท Tests: Lerotinib, Irinotecan/Tegafur Pulsed Dose Chemotherapy Plus Pembrolizumab in Recurrent/Metastatic HNSCC NCT06052839Phase 21 site๐Ÿ“ Pittsburgh Dan Zandberg ยท Tests: Pembrolizumab, Carboplatin, Paclitaxel A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors NCT06465069Phase 139 sites๐Ÿ“ Duarte๐Ÿ“ La Jolla๐Ÿ“ Los Angeles Eli Lilly and Company ยท Tests: LY4052031, Pembrolizumab Alpha Radiation Emitters Device (DaRT) in Combination With Check Point Inhibitor for the Treatment of Recurrent Unresectable or mHNSCC NCT05047094NA3 sites๐Ÿ“ Jerusalem๐Ÿ“ Ramat Gan๐Ÿ“ Tel Aviv Alpha Tau Medical LTD. ยท Tests: Diffusing Alpha Radiation Emitters Therapy (DaRT), Pembrolizumab A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer NCT05420948Phase 21 site๐Ÿ“ Chicago University of Chicago ยท Tests: Pembrolizumab, Carboplatin, Paclitaxel Study of TI-0093 Injection With Recurrent/Metastatic HPV-16 Positive Solid Tumors NCT07081984Phase 11 site๐Ÿ“ Shanghai Therorna ยท Tests: therapeutic tumor vaccine A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression NCT06682793Phase 1, Phase 210 sites๐Ÿ“ Gilbert๐Ÿ“ La Jolla๐Ÿ“ Los Angeles A2 Biotherapeutics Inc. ยท Tests: A2B395, xT CDx with HLA-LOH assay A Study of Nimotuzumab Plus Adebrelimab With Chemotherapy in Cisplatin-Ineligible Patients With Head And Neck Squamous Cell Carcinoma NCT07105592Phase 1, Phase 21 site๐Ÿ“ Shanghai Fudan University ยท Tests: Nimotuzumab+Adebrelimab+Chemotherapy KC1036 in Combination With PD-1 Antibody and Platinum-based Chemotherapy for First-line Advanced Esophageal Cancer NCT07481058Phase 21 site๐Ÿ“ Beijing Beijing Konruns Pharmaceutical Co., Ltd. ยท Tests: KC1036, Toripalimab, Paclitaxel, Cisplatin, KC1036 Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program NCT06265285Phase 21 site๐Ÿ“ Jacksonville Mayo Clinic ยท Tests: Home Health Encounter, Nivolumab, Patient Monitoring, Questionnaire Administration Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/Metastatic HNSCC NCT07040072Phase 11 site๐Ÿ“ Beijing Beijing Tongren Hospital ยท Tests: Stapokibart and Finotonlimab A Study of Pembrolizumab (MK-3475) Plus Platinum and Gemcitabine as First Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (PIPER) NCT05286619Phase 21 site๐Ÿ“ Kuala Lumpur University of Malaya ยท Tests: Pembrolizumab, Cisplatin, Carboplatin, Gemcitabine Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic NCT07807345Phase 16 sites๐Ÿ“ Orlando๐Ÿ“ Boston๐Ÿ“ Oklahoma City Sutro Biopharma, Inc. ยท Tests: STRO-006, Pembrolizumab A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC) NCT07408063Phase 21 site๐Ÿ“ Toronto University Health Network, Toronto ยท Tests: GSK5764227, Dostarlimab Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors NCT04119024Phase 13 sites๐Ÿ“ Duarte๐Ÿ“ Los Angeles๐Ÿ“ Stanford Anusha Kalbasi ยท Tests: Biopsy, Biospecimen Collection, Computed Tomography, Cyclophosphamide, Fludarabine Phosphate A Phase II Clinical Study to Evaluate HLX43 in Patients With Recurrent/Metastatic ESCC Failed or Intolerance to Standard Therapy NCT06769113Phase 21 site๐Ÿ“ Jinan Shanghai Henlius Biotech ยท Tests: HLX43
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