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Clinical trials test new treatments โ€” sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Recurrent High Grade Glioma

Evaluation of Clinical Efficacy and Safety of Specific Mode Electroacupuncture Stimulation for Paclitaxel Across BBB Delivery in Patients With Postoperative Recurrence of Malignant Glioma: A Single-arm Trial NCT06818331Phase 21 site๐Ÿ“ China The Third Affiliated hospital of Zhejiang Chinese Medical Uโ€ฆ ยท Tests: SMES+PTX, Paclitaxel, Specific mode electroacupuncture stimulation CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults NCT06305910Phase 11 site๐Ÿ“ Minneapolis OX2 Therapeutics ยท Tests: Treatment with CD200AR-L Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) Progression NCT06975332NA2 sites๐Ÿ“ Warsaw๐Ÿ“ Warsaw Medical University of Warsaw ยท Tests: Local, targeted therapy with alpha emitter [225Ac]Ac-DOTA-SP (TAT) Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma NCT04547777Phase 11 site๐Ÿ“ Durham Darell Bigner ยท Tests: D2C7-IT, 2141-V11 [177Lu]Lu-DOTA-EB-RGD2 Therapy in Patients With Recurrent High-grade Glioma NCT07655869EARLY Phase 12 sites๐Ÿ“ Beijing๐Ÿ“ Beijing Beijing Tiantan Hospital ยท Tests: [177Lu]Lu-DOTA-EB-RGD2 Study in Children and Adolescents of 177Lu-DOTATATE (Lutatheraยฎ) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). NCT06607692Phase 1, Phase 21 site๐Ÿ“ Boadilla del Monte Fundaciรณn de investigaciรณn HM ยท Tests: Olaparib; 177Lu-DOTATATE Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 NCT06126744Phase 12 sites๐Ÿ“ New York๐Ÿ“ Durham Duke University ยท Tests: MVR-C5252 A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma NCT07464925Phase 13 sites๐Ÿ“ Tampa๐Ÿ“ Chicago๐Ÿ“ New York Tetragon Biosciences Ltd ยท Tests: GLIX1 A Clinical Trial Evaluating the Tolerability, Safety, and Preliminary Efficacy of NRG-103 Injection in Patients With Recurrent or Progressive High-grade Glioma NCT07710690Phase 13 sites๐Ÿ“ Shanghai๐Ÿ“ Wuhan๐Ÿ“ Xi'an Neuregen Therapeutics Co., Ltd. ยท Tests: NRG-103 000860: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations NCT05588141Phase 1, Phase 22 sites๐Ÿ“ Jacksonville๐Ÿ“ Bethesda National Cancer Institute (NCI) ยท Tests: Zotiraciclib A Phase I Clinical Trial of a mRNA Vaccine for Recurrent or Progressive High-grade Glioma NCT07306299Phase 11 site๐Ÿ“ Hangzhou Second Affiliated Hospital, Zhejiang University, School of โ€ฆ ยท Tests: Glioma-related multi-target mRNA vaccines Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma NCT07416188Phase 1, Phase 21 site๐Ÿ“ Bethesda National Institute of Neurological Disorders and Stroke (NIโ€ฆ ยท Tests: LMP744, Conventional Surgery or Biopsy Chronic CED of TPT for Recurrent Malignant Glioma NCT06666712Phase 11 site๐Ÿ“ New York Jeffrey N. Bruce ยท Tests: Topotecan Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rฮฑ2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas NCT07544992Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Autologous Anti-EGFR/Anti-IL13Ralpha2 CAR T-cells, Biopsy Procedure, Biospecimen Collection, Echocardiography Test, FDGโ€ฆ Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) NCT04485559Phase 117 sites๐Ÿ“ Birmingham๐Ÿ“ Los Angeles๐Ÿ“ San Diego University of California, San Francisco ยท Tests: Everolimus, Trametinib ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas NCT06838676Phase 220 sites๐Ÿ“ Aurora๐Ÿ“ Washington D.C.๐Ÿ“ Miami Nationwide Children's Hospital ยท Tests: ACT001 Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection NCT06018363Phase 1, Phase 21 site๐Ÿ“ Suzhou Dushu Lake Hospital Affiliated to Soochow University ยท Tests: Allogenic B7-H3 CAR-ฮณฮดT cell(QH104) An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma NCT06444412Phase 21 site๐Ÿ“ Rochester Mayo Clinic ยท Tests: Computed Tomography, Electronic Health Record Review, Ga 68 PSMA-11, Positron Emission Tomography MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma NCT03896568Phase 11 site๐Ÿ“ Houston M.D. Anderson Cancer Center ยท Tests: Oncolytic Adenovirus Ad5-DNX-2401, Therapeutic Conventional Surgery Intracranial Genetically Modified Immune Cells (TGFฮฒR2KO/IL13Rฮฑ2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma NCT06815029Phase 11 site๐Ÿ“ Duarte City of Hope Medical Center ยท Tests: Biospecimen Collection, Chimeric Antigen Receptor T-Cell Therapy, Echocardiography, Fludeoxyglucose F-18, Intracranial โ€ฆ Sitagliptin in Recurrent/Progressive Grade 4 Glioma NCT07541781Phase 11 site๐Ÿ“ Iowa City Kailin Yang, MD, PhD ยท Tests: Sitagliptin, Bevacizumab MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas NCT06712875Phase 1, Phase 23 sites๐Ÿ“ Washington D.C.๐Ÿ“ Chicago๐Ÿ“ New York Ann & Robert H Lurie Children's Hospital of Chicago ยท Tests: Trametinib and Nivolumab, Dabrafenib, trametinib, nivolumab Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors NCT07424092Phase 22 sites๐Ÿ“ Utrecht๐Ÿ“ Pamplona Clinica Universidad de Navarra, Universidad de Navarra ยท Tests: DNX-2401 A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) NCT04573140Phase 12 sites๐Ÿ“ Washington D.C.๐Ÿ“ Gainesville University of Florida ยท Tests: Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liโ€ฆ A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. NCT07017816EARLY Phase 11 site๐Ÿ“ Washington D.C. Children's National Research Institute ยท Tests: SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma NCT05698524Phase 11 site๐Ÿ“ Omaha University of Nebraska ยท Tests: PCI 24781, Temozolomide BC008-1A Injection for Recurrent CNS WHO G4 Glioma NCT06773481Phase 11 site๐Ÿ“ Beijing Sichuan Luzhou Buchang Biopharmaceutical Co., Ltd. ยท Tests: BC008-1A, BC008-1A Recurrent High Grade Glioma Treated by LITT NCT06161610NA9 sites๐Ÿ“ Beijing๐Ÿ“ Beijing๐Ÿ“ Guangzhou Beijing Tiantan Hospital ยท Tests: LITT, Control Study of Letrozole in Recurrent Gliomas NCT03122197EARLY Phase 11 site๐Ÿ“ Cincinnati University of Cincinnati ยท Tests: Letrozole Oral Tablet, Temozolomide CARv3-TEAM-E T Cells in Glioblastoma NCT05660369Phase 11 site๐Ÿ“ Boston Marcela V. Maus, M.D.,Ph.D. ยท Tests: CARv3-TEAM-E T cells
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