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Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Squamous Cell Carcinoma of the Oropharynx

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma NCT03556228Phase 1, Phase 215 sites📍 Santa Rosa📍 Hartford📍 Washington D.C. VM Oncology, LLC · Tests: VMD-928 100 mg Tablet, VMD-928 Tablet and Pembrolizumab (200 mg) Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus NCT05918510n/a1 site📍 Rome Regina Elena Cancer Institute · Tests: Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer NCT07667400Phase 1, Phase 21 site📍 Bethesda National Cancer Institute (NCI) · Tests: SX-682, DTX Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma NCT03215719Phase 21 site📍 New York NYU Langone Health · Tests: Standard Radiation Treatment, Dose-Deescalated Treatment, Cisplatinum De-escalation of Adjuvant Radio (Chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas NCT03396718NA10 sites📍 Tübingen📍 Essen📍 Dresden Technische Universität Dresden · Tests: De-escalation radio(chemo)therapy - Level 1, De-escalation radio(chemo)therapy - Level 2, Standard radio(chemotherapy) Dual-energy CT vs. MRI in the Evaluation of Squamous Cell Carcinomas of the Oral Cavity and Oropharynx NCT07343271n/a1 site📍 Strasbourg University Hospital, Strasbourg, France Shortened Course of Radiation Therapy After Trans-oral Robotic Surgery in Patients With HPV-Mediated Oropharyngeal Squamous Cell Carcinoma. NCT07044635Phase 21 site📍 Salt Lake City University of Utah · Tests: Radiation Therapy TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer NCT06868433Phase 12 sites📍 Atlanta📍 Atlanta Emory University · Tests: Autologous Tumor Membrane Vesicles Vaccine, Biospecimen Collection, Computed Tomography, Echocardiography, Magnetic Res… Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery NCT06747390Phase 11 site📍 Philadelphia Ryan Carey · Tests: Lidocaine 1% Injectable Solution Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Advanced Head and Neck Cancer Who Cannot Receive Cisplatin NCT07441681Phase 3150 sites📍 Birmingham📍 Anaheim📍 Baldwin Park NRG Oncology · Tests: Biospecimen Collection, Carboplatin, Cetuximab, Computed Tomography, Intensity-Modulated Radiation Therapy Radiotherapy vs. Trans-Oral Surgery for HPV-Negative Oropharyngeal Squamous Cell Carcinoma NCT04220749Phase 21 site📍 London London Health Sciences Centre Research Institute OR Lawson … · Tests: Radiation, Trans-Oral Surgery (TOS) + Neck Dissection Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study NCT04900623Phase 22 sites📍 Boston📍 Boston Jonathan Schoenfeld, MD, MPH · Tests: NavDx HPV ctDNA Testing, Radiotherapy, Chemotherapy drug A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze) NCT05894083Phase 21 site📍 Ann Arbor University of Michigan Rogel Cancer Center · Tests: Surgery, Chemoradiation, Observation, Post-operative radiation Thermotherapy for Head and Neck Cancer Patients NCT07690618Phase 11 site📍 Rotterdam Erasmus Medical Center · Tests: Thermotherapy, Radiotherapy, Concurrent chemoradiation Phase 1 Clinical Trial of FluBHPVE6E7 Immunotherapy for HPV16-Associated Oropharyngeal Cancer NCT06589609Phase 11 site📍 Vienna BlueSky Immunotherapies GmbH · Tests: FluBHPVE6E7 Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer NCT05388773Phase 21 site📍 Pittsburgh Heath Skinner · Tests: therapeutic conventional surgery, laboratory biomarker analysis, quality-of-life assessment, intensity-modulated radiat… ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the Oropharynx NCT06915038NA2 sites📍 Carmel📍 Indianapolis Indiana University · Tests: NavDx, Adjuvant Radiation 30 Gray, Adjuvant Radiation 40 Gray The Minimalist Trial-2 NCT06702033Phase 23 sites📍 St Louis📍 Fargo📍 Sioux Falls Washington University School of Medicine · Tests: Radiation therapy, Cisplatin, Surgery Neoadjuvant Sintilimab Combined With Reduction of Cycles of Chemotherapy in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma (OOC-002) NCT05098119Phase 21 site📍 Guangzhou Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Tests: Sintilimab, Nab-paclitaxel, Carboplatin, Surgical resection, Sintilimab Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and Outcome NCT06380686n/a2 sites📍 Essen📍 Hanover AIO-Studien-gGmbH · Tests: data collection De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) NCT06307015NA1 site📍 Saint Leonards Royal North Shore Hospital · Tests: De-escalation, Standard of care Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery NCT02734537Phase 2679 sites📍 Birmingham📍 Anchorage📍 Anchorage ECOG-ACRIN Cancer Research Group · Tests: Cisplatin, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) NCT06088381Phase 25 sites📍 Baltimore📍 Baltimore📍 Bel Air University of Maryland, Baltimore · Tests: Experimental Observation, Observation per Standard of Care, Adjuvant Treatment per Standard of Care, Circulating Tumor … Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation NCT06662058NA1 site📍 Atlanta Emory University · Tests: Audiometric Test, Audiometric Test, Audiometric Test, Interview A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC NCT07133958n/a1 site📍 Guangzhou Zhujiang Hospital Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer NCT06914999EARLY Phase 11 site📍 Atlanta Emory University · Tests: Computed Tomography, Fludeoxyglucose F-18, Intensity-Modulated Proton Therapy, Intensity-Modulated Radiation Therapy, P… Intranasal WSK-IM05 Vaccine Plus Tislelizumab as Neoadjuvant Therapy for HPV+ OPSCC NCT07565740Phase 11 site📍 Chengdu West China Hospital · Tests: WSK-IM05 (4×10^10 vp), WSK-IM05 (8×10^10 vp), WSK-IM05 (1.6x10^11 vp), Tislelizumab Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer NCT06323460Phase 21 site📍 Columbus Ohio State University Comprehensive Cancer Center · Tests: Biospecimen Collection, Carboplatin, Cisplatin, Computed Tomography, External Beam Radiation Therapy E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers NCT05686226Phase 23 sites📍 Bethesda📍 New Brunswick📍 New Brunswick Christian Hinrichs · Tests: E7 TCR-T cells, Aldesleukin A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer NCT05544136Phase 26 sites📍 Basking Ridge📍 Middletown📍 Montvale Memorial Sloan Kettering Cancer Center · Tests: 18F-FMISO PET/CT scan, Chemoradiation therapy, Carboplatin
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