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Trial Match

Clinical trials test new treatments — sometimes the newest options available for a disease. Find trials that are recruiting now, near you. Open one to see its eligibility rules as simple questions to go through with your doctor.

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30 recruiting trials

for Treatment-resistant Depression (TRD)

Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression NCT07146503n/a5 sites📍 Genova📍 Genova📍 Chieti Riccardo Guglielmo · Tests: Esketamine (Intranasal Spray) One-Day cTBS Over the Precuneus NCT07758010NA1 site📍 Belmont Mclean Hospital · Tests: Precuneus-targeted continuous theta-burst stimulation, Left dorsolateral prefrontal cortex intermittent theta-burst sti… Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression NCT07563868NA2 sites📍 Boston📍 Boston Massachusetts General Hospital · Tests: Psychedelic Integration Coaching Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression NCT07673913NA2 sites📍 Ankara📍 Ankara Gulhane Training and Research Hospital · Tests: Intermittent Theta Burst Stimulation (iTBS) A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression. NCT03320304n/a18 sites📍 Vienna📍 Leuven📍 Bamberg LivaNova · Tests: Vagal Nerve Simulation (VNS) Therapy A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial NCT07227103Phase 2, Phase 33 sites📍 Sarasota📍 West Palm Beach📍 Belmont NeuroRx, Inc. · Tests: Neuronavigated robotic-enabled TMS, NRX-101, Sham TMS, Oral Placebo Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression NCT07094789NA1 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: Next Generation Dome Helmet (NGDH) Cannabidiol Oil for Treatment-Resistant Major Depression NCT07696871Phase 1, Phase 21 site📍 Tubarão Universidade do Sul de Santa Catarina · Tests: Full-spectrum CBD oil 100 mg/mL, Placebo oil (MCT oil) COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression NCT06895863NA3 sites📍 Glostrup Municipality📍 Hilleroed📍 Hvidovre Danish Research Centre for Magnetic Resonance · Tests: MagVenture XP Orange Stimulator and active side of MagVenture COOL-B65 coil., Device: MagVenture XP Orange Stimulator a… TACS on High-inflammatory and Refractory Depression NCT06812923NA1 site📍 Tianjin Tianjin Anding Hospital · Tests: transcranial Alternating Current Stimulation (tACS), Sham stimulation Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment NCT07741981NA1 site📍 Paris Centre Hospitalier St Anne · Tests: Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales Dehydroepiandrosterone (DHEA) as Augmentation of Standard Antidepressants in Treatment-resistant Depression. NCT07843927Phase 39 sites📍 Berlin📍 Augsburg📍 Berlin Charite University, Berlin, Germany · Tests: Dehydroepiandrosterone (DHEA), Placebo Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ) NCT07210112Phase 21 site📍 Paris Centre Hospitalier St Anne · Tests: Psilocybin 25 mg per os, Trazodone 5mg, Trazodone 30 mg, Placebo of psilocybin, Placebo of trazodone Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression NCT07080723Phase 41 site📍 Aalborg Aalborg University Hospital · Tests: Algorithm guided treatment (AGT), Treatment as usual (TAU) Esketamine With or Without Integration Therapy for Treatment-Resistant Depression NCT07369102Phase 42 sites📍 San Juan📍 San Juan University of Puerto Rico · Tests: Esketamine hydrochloride (intranasal), Integration Therapy Treatment Resistant Depression and Vagus Nerve Stimulation NCT05952674NA24 sites📍 Angers📍 Bordeaux📍 Caen Assistance Publique - Hôpitaux de Paris · Tests: Vagus Nerve Stimulation (VNS), Best Medical Treatment Identifying Local Field Potential Biomarkers for Treatment-Resistant Major Depression With Deep Brain Stimulation NCT06542094NA1 site📍 Chengdu West China Hospital · Tests: Deep Brain stimulation Feasibility Trial of Exercise as a Priming Strategy for rTMS Treatment in Difficult-to-Treat Depression NCT06773949NA1 site📍 Ottawa The Royal Ottawa Mental Health Centre · Tests: Theta burst stimulation Intravenous Ketamine for Treatment-Resistant Depression NCT06668571Phase 21 site📍 Rochester Mayo Clinic · Tests: Ketamine, Normal Saline Accelerated iTBS for Major Depression NCT07603804NA1 site📍 Istanbul Istanbul University - Cerrahpasa · Tests: Accelerated Intermittent Theta Burst Stimulation (iTBS) ALTO-207 in Adults With Treatment-resistant Depression (TRD) NCT07553637Phase 263 sites📍 Dothan📍 Phoenix📍 Chino Alto Neuroscience · Tests: ALTO-207, Placebo DBS for Depression NCT06096207Phase 11 site📍 Queens Northwell Health · Tests: Medtronic SenSight Directional DBS lead Personalized DBS Targeting for Treating Depression NCT06784388EARLY Phase 11 site📍 Hangzhou Second Affiliated Hospital, Zhejiang University, School of … · Tests: Deep Brain Stimulation(DBS), Esketamine Ketogenic Diet and Neuromodulation in Treatment Resistant Depression NCT07376018NA1 site📍 Toronto Sunnybrook Health Sciences Centre · Tests: Accelerated Intermittent Theta Burst Stimulation (iTBS), Ketogenic Diet, Canadian Food Guide-Aligned Diet Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study NCT07217223NA1 site📍 San Diego University of California, San Diego · Tests: Spaced Transcranial Direct Current Stimulation (tDCS) Biomarker-Guided Antidepressant Selection NCT07680140Phase 41 site📍 New York Weill Medical College of Cornell University · Tests: TMS, Ketamine Physical Activity Program for TRD NCT06404320NA1 site📍 Toronto Unity Health Toronto · Tests: PA program - MoveU.HappyU A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression NCT03887715NA101 sites📍 Birmingham📍 Huntsville📍 Burlingame LivaNova · Tests: Vagus Nerve Stimulation (VNS) DBS for TRD With the Medtronic Percept PC NCT05773755NA1 site📍 New York Helen Mayberg, MD · Tests: Medtronic Percept PC DBS system Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression NCT07226232Phase 35 sites📍 Birmingham📍 Tuscaloosa📍 Portland VA Office of Research and Development · Tests: Psilocybin, Psilocybin
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