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Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation

Recruitingn/aAges 18 Years - anyAllUniversity of Alberta
NCT01299168 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The current standard for biopsy-based diagnoses of dysfunction of kidney transplants is the Banff Classification which represents arbitrary international consensus. Recent data-driven approaches using molecular and conventional technologies indicate that mere consensus produces frequently incorrect diagnoses with potential harm to patients due to inappropriate treatment. To address this unmet need and improve diagnostics in the area of organ transplantation, the Alberta Transplant Applied Genomics Centre (ATAGC) has developed a new diagnostic system that combines the molecular and histopathological features of transplant biopsies, plus clinical and laboratory parameters, to create the first Integrated Diagnostic System. The present study will validate and refine this system in 500 prospectively unselected biopsies for clinical indications from American, Canadian and European centres in a

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📋 Eligibility rules (as published)
Inclusion Criteria: * All kidney transplant recipients ≥18yrs of age undergoing a kidney biopsy for clinical indications, as determined by their physician or surgeon, will be eligible to enrol in the study. Exclusion Criteria: * Patients will be excluded from the study if they decline participation or are unable to give informed consent.
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What it tests

  • Not listed
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Where

26 sites
University of Alabama
Birmingham, United States
University of Maryland School of Medicine
Baltimore, United States
University of Michigan Health System
Ann Arbor, United States
University of Minnesota
Minneapolis, United States
Barnes-Jewish Hospital
St Louis, United States
Montefiore Medical Center
The Bronx, United States
Pinnacle Transplant Associates
Harrisburg, United States
Texas Transplant Institute - Methodist Healthcare System
San Antonio, United States

…and 18 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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