Kidney Cancer DNA Registry

Inclusion Criteria: Kidney Cancer Case Cohort: * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must have a diagnosis or suspicion of kidney cancer Family Member Cohort: * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must be a blood relative of the proband. Family members of probands including mother, father, sisters, brothers, half-sisters, half-brothers, daughters, sons, grandmothers, grandfathers, as well as aunts and uncles are eligible. These individuals need not have kidney cancer, as they will be used for segregation analysis of suspected variants found in the proband; requesting DNA from relatives is required. Control Cohort: * Must be ≥ 18 years of age AND * Must be an English-speaker AND * Must not have a personal history of cancer, with the exception of nonmelanoma skin cancer, AND * Must not be a blood relative of any cases or controls enrolled in this study Exclusion Criteria: * Patients who, in the opinion of the primary MSKCC clinician or the investigator, have a condition that precludes their ability to provide an informed consent