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Biomoleculars Markers of Sensitivity to Pre- and Post-operative Chemotherapy of Gastric and Cardia Adenocarcinomas: a Pilot Study

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Strasbourg, France
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In plain words

What the trial is, and whether it could suit you

Some subtypes of gastric and cardia tumors such as adenocarcinoma or gastric linitis with disseminated cells respond poorly to the pre-operative chemotherapy, and some of them do not respond to chemotherapy usually performed. Doing chemotherapy in these patients could delay their surgical management. The completion of chemotherapy for these patients would be a bad prognosis factor according to recent data from the literature. Therefore, the aim of this research is to find prognostic markers of sensitivity to chemotherapy usually performed. The investigators are going to use biopsies realized at diagnosis and select patients "good and bad" responders. Primary purpose: To study cardia and gastric tumors, molecular markers sensitivity to pre- and post- perative chemotherapy protocols (EOX protocol ... FOLFOX) or chemoradiation Secondary purposes: * To assess the impact of patients' life

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: Gastric adenocarcinoma (any location) or cardia adenocarcinoma * Age\> 18 years * WHO Indexโ‰ค 3 * Subject having signed an informed consent Exclusion Criteria: * Other cancers undergoing chemotherapy treatment * Pregnant or breastfeeding * Inability to understand information (understanding with difficulties ...)
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What it tests

  • Biopsy
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Where

1 site
University Hospital, Strasbourg, france
Strasbourg, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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