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Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis

Recruitingn/aAges 18 Years - 85 YearsAllSamsung Medical Center
NCT02798705 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac amyloidosis. The second objective of this study is to compare results of non-invasive test including serum light chain amount, Doppler echocardiography with 2D strain, and cardiac perfusion MRI. The third object of this study is to evaluate the association between physiologic indices and pathologically measured percent area involvement of interstitium.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Subject age 18-85 years old * Patients with confirmed cardiac amyloidosis by heart biopsy * Patients with confirmed amyloidosis by biopsy other than heart and evidence of cardiac involvement in echocardiography * Patients who underwent invasive physiologic assessment within 3 months from diagnosis of primary disease Exclusion Criteria: * Patients with cardiogenic shock * Patients with unstable vital sign that precludes coronary angiography * Patients with major bleeding in last 3 months * Patients with active bleeding * Patients with coagulopathy * Patients with severe valvular heart disease * Patients who refused to provide informed consent
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What it tests

  • Not listed
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Where

1 site
Samsung Medical Center
Seoul, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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