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In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma

RecruitingPhase 1Ages 0 Years - 64 YearsAllUniversity Health Network, Toronto
NCT02811523 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Sarcoma which has spread to the lungs is most often treated with surgery. Even with surgery, most patients will not be cured and will die from their disease, probably because of small cancer cells that are present in the lungs at the time of surgery, but cannot be seen or detected. It is for this reason that we are looking for a better treatment. Giving chemotherapy after surgery is generally not recommended because it has significant side effects and no benefit has been proven. This study is investigating a new technique for delivering chemotherapy directly into the lungs at the time of surgery. Delivering chemotherapy directly to the lungs could potentially kill any microscopic cancer cells that are present in the lungs at the time of surgery, while sparing other major organs in the body from the side effects of chemotherapy. This technique is called In Vivo Lung Perfusion (IVLP). Thi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of Soft Tissue or Osteogenic Sarcoma * Presence of bilateral pulmonary metastases * 3 or more lung lesions in total * Age less than 65 years * ECOG 0-2 * Absence of extra-pulmonary disease * Contralateral disease amenable to surgery or radiation * All lung lesions in the lung to be treated with IVLP can be resected with wedge or segmental resections (non-IVLP treated lung will be treated with radiation or surgery 4-12 weeks prior to IVLP) Exclusion Criteria: * Patient has previously received more than 450 mg of doxorubicin * Left Ventricular Ejection Fraction \<50% * History of significant pulmonary disease or pneumonitis * Pregnant or lactating females * Age 65 years or older, or less than 18 years * Inability to understand the informed consent process * Hypersenstivity to doxorubicin * Current participation in another therapeutic clinical trial * Previous lung metastatectomy
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What it tests

  • Doxorubicin
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Where

1 site
Princess Margaret Cancer Centre
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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