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Lung Cancer Screening in a Population Exposed to Occupational Lung Carcinogens

Recruitingn/aAges 55 Years - 74 YearsAllCentre Hospitalier Intercommunal Creteil
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In plain words

What the trial is, and whether it could suit you

The good clinical practice guidelines for the surveillance of workers after occupational exposure to lung carcinogens were approved by the Haute Autorité de la Santé (French National Authority for Health) and the Institut National du Cancer (French National Cancer Institute) in December 2015 and one recommendation of these guidelines concerns the setting-up of a trial of low-dose chest computed tomography (CT) lung cancer screening in subjects occupationally exposed to lung carcinogens at high-risk of lung cancer (Expert consensus). In LUCSO study, the investigators propose to conduct, under strictly defined conditions, a feasibility study of lung cancer screening in a population defined as being at high risk of lung cancer according to these good clinical practice guidelines. This population consists of smokers, aged from 55 to 74 years, currently or previously exposed to International

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📋 Eligibility rules (as published)
Inclusion Criteria: Subjects at high risk of lung cancer: current smokers smoking 30 pack-years or more or ex-smokers smoking 30 pack-years or more and who have quit smoking for less than 15 years and currently or previously occupationally exposed to lung carcinogens. With an algorithm for determination of minimal duration of exposure to occupational carcinogens (according to the type and duration of occupational lung carcinogens) Exclusion Criteria: * Presence of clinical signs of lung cancer * Subjects with a history of lung cancer * Presence of serious short-term life-threatening comorbidities * Absence of occupational exposure to lung carcinogens according to the predefined criteria * Subjects already included in another prospective cohort study * Subjects already assessed by chest CT scan during the previous year * No tobacco exposure or insufficient tobacco exposure or smoking cessation for more than 15 years.
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What it tests

  • Not listed
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Where

8 sites
Centre Hospitalier Universitaire de Bordeaux
Bordeaux, France
Université de Bordeaux
Bordeaux, France
Centre Hospitalier Universitaire de Brest
Brest, France
Centre Hospitalier Universitaire de Caen
Caen, France
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Centre Hospitalier Universitaire de Rennes
Rennes, France
Centre Hospitalier Universitaire de Rouen
Rouen, France
Hôpital d'Instruction des Armées Sainte-Anne
Toulon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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