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Pharmacogenetic Testing of Patients With Unwanted Adverse Drug Reactions or Therapy Failure

Recruitingn/aAges 2 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT04154553 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Genetic makeup of a patient influences the efficacy and safety profile of a drug. This study is to summarize individual cases, where Pharmacogenetics (PGx) has been applied during pharmaceutical care. The primary objective is the compilation of case reports, where pharmacogenetic testing is applied to determine the hereditable component of the patient's susceptibility to experience therapy failure and/or adverse drug reactions. The experience with the compiled cases will be basis for the development of a reliable standard of procedure for pharmacogenetic testing in the community pharmacy. The cases will be supplemented with information on additional Parameters reported in the literature to affect efficacy or safety of the respective drug.

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📋 Eligibility rules (as published)
Inclusion Criteria: * New medication with known PGx association (preemptive) * Current medication with observation of adverse drug reactions probably linked to drugs with known PGx association (reactive) * Current medication with observation of therapy failure probably linked to drugs with known PGx association (reactive) * Current and/or new medication and a family history of adverse drug reactions/therapy failure probably linked to drugs with known PGx association * Signed informed consent; for patients \< 14 years, the legal representative needs to sign the informed consent Exclusion Criteria: * Insufficient German knowledge * Not able to personally visit to the study pharmacy
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What it tests

  • Buccal swab
  • EDTA Blood sample (4.9mL)
  • Serum sample (7.5mL)
  • communication of test results
  • unstructured interview
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Where

1 site
Department of Pharmaceutical Sciences, University Basel
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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