Butyrophilins Role in Colon Cancer

Inclusion Criteria: * Patient is older than 18 years old, * Signed participation consent, * Non-metastatic colon cancer immediately resectable or metastatic and liver synchronous for which it was decided a combined colic and liver surgery (metastatic patient at the outset) in multidisciplinary consultation meeting. * Performance Status (PS) 0 or 1 * affiliated to the social security or beneficiary Exclusion Criteria: * Rectal cancer, colon cancer recurrence * Emergency of colon cancer Surgery * History of inflammatory disease of the digestive tract (Crohn's disease or ulcerative colitis) * Patient who received neoadjuvant therapy other than chemotherapy * Patient treated with immune-suppressors or long-course corticosteroids \<12 months * Pregnant women or likely to be pregnant (without effective contraception) or breastfeeding, * Person in urgent situation, person under legal protection measure, or unable to express his / her consent, * Impossibility of submitting to the medical examination of the test for geographical, social or psychological reasons