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Effects of Exercise on Thoracic Aneurysms

RecruitingNAAges 18 Years - anyAllLaval University
NCT04197648 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Thoracic aneurysm incidence is estimated to 4.5 cases per 100 000. The manifestation as well as natural history of thoracic aneurysm depend on many factors such as its localisation, its diameter, presence of collagen disease and family history. For the ascendant aortic aneurysm, it is often linked to a degeneration of the media arterial layer of the arterial wall. The media degeneration is cause by the degeneration of the elastic fibres, which lead to a weakening of the arterial wall accompanied with dilation. This process is often due to age and is accelerated by high blood pressure. Amongst the numerous factors causing the aneurysm, the investigators find: hypertension, aortic bicuspid valve, smoking, atherosclerosis, trauma and genetic predisposition. The average growth rate of thoracic aneurysm is 0.1-0.2 cm/year. The risk of rupture is associated to the size of the aneurysm as well

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years and older * Have an interest in participating in a supervised exercise training program * Aortic diameter between 3,5 and 5 cm Exclusion Criteria * Glomerular filtration rate below 30 mL/min/1.73m² * Aortic diameter greater than or equal to 5.1 cm * Progression of aortic diameter greater than or equal to 0.5 cm per year * Allergy to iodine * Aortic valve bicuspidy * History of aortic surgery or cardiac surgery * Presence of an aortic dissection, penetrating aortic ulcer, or intra-mural hematoma of the aorta * Presence of Marfan syndrome or other genetic and/or congenital disease explaining the thoracic aortic aneurysm * History of stroke * Presence of peripheral artery disease * History and/or presence of aortitis * Known diagnosis of temporal arteritis or rheumatoid arthritis * Presence of a pacemaker * Major cognitive limitation that may affect adherence to visits * Musculoskeletal limitation that restricts participation in the training program
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What it tests

  • Exercise group
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Where

2 sites
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Canada
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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