🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths

RecruitingNAAges 18 Years - 40 YearsAllUniversity Hospital, Brest
NCT04207814 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from trimester 1 of pregnancy) and 93 from the unexplained fetal death in utero (FDIU) subgroup from trimesters 2 and 3 of pregnancy. The main objective of the DEFI 2 study is to increase the number of case-pairs in these 2 particular subgroups to replicate the results of the genetic determinants highlighted from cases and controls with extreme phenotypes and obtain a sufficient number of women with FDIUs to identify specific determinants.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * couples whose wife is over 18 and under 40 inclusive, * couples having undergone at least 3 unexplained SM in the first trimester or an FDIU in the trimesters 2 and 3 of pregnancy (excluding funicular and fetal causes and proven preeclampsia) * the man must be over 18 years old. * each member of the couple must consent to the investigation. * Subjects benefiting from a social security scheme. Exclusion Criteria: * couples where the woman is under 18 or over 40, * couples whose man is under 18, * identified cause of SRM or FDIU * Inability to consent for one of the members of the couple, * refusal to participate for one of the members of the couple. * treatment with anticoagulants or anti-aggregating platelet for women. * Person under legal protection * Subjects not benefiting from a social security scheme * Refusal to participate
💊

What it tests

  • biological sample
📍

Where

1 site
BREST
Brest, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy