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Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block

RecruitingPhase 4Ages 18 Years - 75 YearsAllChinese University of Hong Kong
NCT04397484 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Sciatic nerve block at the popliteal fossa is indicated for foot or ankle surgery, and the introduction of ultrasound guidance (USG) has improved the ease and accuracy of the performance of this block. Recent studies proved that subparaneural injection is associated with faster block onset, higher block success rate, and prolonged block duration suggesting subparaneural compartment of the sciatic nerve is a desirable site for local anaesthetic injection. Data from an ongoing trial in the investigator's institution comparing the block dynamics of subparaneural injection of 30ml 0.5% levobupivacaine (Chirocaine) above and below the bifurcation of the sciatic nerve at popliteal fossa has also shown that the time to 'readiness for surgery' was faster when the injection was performed below the bifurcation of the sciatic nerve. Lidocaine (Xylocaine) has a better pharmacokinetic and pharmacodyn

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📋 Eligibility rules (as published)
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I-III * adult and scheduled to undergo elective forefoot surgery under regional anaesthesia Exclusion Criteria: * patient refusal * ASA physical status \> III * pregnancy * neuromuscular disorder * prior surgery in the popliteal fossa * coagulopathy * allergy to local anaesthetic drugs * skin infection at the site of needle insertion
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What it tests

  • 0.5% Levobupivacaine
  • 2% Xylocaine with adrenaline 1:200,000
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Where

1 site
Prince of Wales Hospital
Shatin, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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