VACcination of LIver Transplantation Candidates

Inclusion Criteria: * age ≥ 18 years old * patients waiting for liver transplantation referred by hepato-gastroenterology department as part of the pre-transplant evaluation to the infectiology consultation * patient who were informed of the study and did not object to participate Exclusion Criteria: * patient candidate for multi-organ transplant * patient who received immunosuppressive therapy, biotherapy and/ or corticosteroid therapy at a dose greater than 10 mg / day of prednisone equivalent for more than 2 weeks within 3 months before vaccination (6 months of rituximab) * patient who received polyvalent immunoglobulins within the 6 months before the serological evaluation * patient who received systemic anti-cancer chemotherapy for solid tumor or hemopathy within 6 months preceding the start of vaccination * splenectomized patients * asplenic patients for a reason other than liver disease * chronic infection with the human immunodeficiency virus (HIV) * patient with any other hereditary immune deficiency or acquired which could compromise the vaccine response or interpretation of serological results * patient under legal protection measure or unable to consent to the study