Natural History of Autosomal Dominant Hearing Loss

* INCLUSION CRITERIA: * Affected persons with autosomal dominant hereditary sensorineural hearing loss, preferably confirmed by prior genetic testing * Affected family members of enrolled participants with known autosomal dominant hereditary hearing loss * Unaffected Family Members (Healthy Volunteers) of enrolled participant * Adults must be able to provide informed consent * Minors must have a parent or guardian able to provide informed consent * Subjects must be 3-99 years of age EXCLUSION CRITERIA: * Persons with sensorineural hearing loss (SNHL) and/or peripheral vestibular dysfunction associated with a non-genetic etiology such as infection, metabolic or immunologic disorders, or exposure to ototoxic agents such as cisplatin, or aminoglycoside antibiotics will not be included in this protocol. * Persons with sensorineural hearing loss known to be associated with surgical intervention (e.g. acoustic neuroma removal, failed stapedectomy). Prospective study subjects who are cognitively impaired and lack consent capacity, will not be enrolled. The pre-screening eligibility checklist, which will be used and documented for registration under this protocol, is provided in a separate document.