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Multimodal Neuroprognostication in Disorders of Consciousness

Recruitingn/aAges 18 Years - 80 YearsAllAssistance Publique - Hôpitaux de Paris
NCT04534777 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Disorders of consciousness frequently occur at the acute phase of brain injuries. For the most severe cases, consciousness impairment can be prolonged. To optimize the medical plan and the goal of care, it is fundamental to have precise tools to predict chances of recovery of consciousness and potential disability. Currently, multimodal assessment including behavioral, neurophysiological and neuroimaging technics is recommended. However, the respective predictive values of these markers are poorly understood and decision making is challenging when results are contradictory

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Consciousness disorder (acute sub-acute or chronic for which our expertise is requested to better characterize the diagnostic and prognosis of recovery) 2. Brain injuries on CT or MRI (e.g. TBI) (traumatic brain-injured ), anoxia or stroke related lesions, etc…) 3. Age between 18 and 80 years Exclusion Criteria: 1. Deep sedation (e.g. elevated ICP(intracranial pressure ), refractory status epilepticus) 2. Sever known neurodegenerative disease (e.g. Alzheimer disease) 3. Pregnancy
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What it tests

  • repeated neurological, behavioral assessments and conventional, quantitative and functional brain imagery
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Where

1 site
Hôpital Pitié Salpétrière
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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