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Genetic Variants and Regulation of Specialized Pro-resolving Mediator

Recruitingn/aAges 18 Years - anyAllQueen Mary University of London
NCT04698291 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Inflammation is the way that the body reacts against infection, injury or illness. An uncontrolled inflammatory response can lead to the development of inflammatory diseases, such as rheumatoid arthritis and cardiovascular conditions. Recent studies have shown that inflammation is a regulated process coordinated by a group of molecules known as specialized pro-resolving mediator (SPM). These molecules are produced by enzymes via the enzymatic conversion of essential fatty acids; whereas their biological actions are mediated by proteins expressed on the surface of cells known as receptors. Given the central role that pro-resolving mediators play in regulating the immune response, the aim of this study is to investigate whether there are genetic variants (mutations) in genes encoding for enzymes and receptors involved in the biology of these molecules and to determine how these mutations

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📋 Eligibility rules (as published)
Inclusion Criteria: * Current volunteer of the Genes \& Health program with (test) or without (control) relevant genetic mutations. Genes \& Health is a huge long-term study of 100,000 people of Bangladeshi and Pakistani origin focuses to link genes with health records and to study disease and treatments. When a volunteer participates in this program, they agree to the possibility to be invited for further studies. Gene \& Health program invites volunteers to take part in two regions of the UK: East London and Bradford. Exclusion Criteria: 1. Volunteer that has not had their genome sequenced after taking part in Stage 1 of Genes \& Health program. 2. Volunteer with significant genetically inherited conditions. 3. Any abnormality or pre-existing disease which, in the opinion of the investigator, might either expose the subject to risk, or influence the validity of the results. 4. Volunteer that went under surgery and are recovering. 5. Participation in a clinical study of a new chemical entity, biological product or a prescription medicine, or loss of more than 400 mL blood, within the previous 3 months. 6. Presence or history of drug or alcohol abuse.
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What it tests

  • Blood Donation
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Where

1 site
Queen Mary University of London
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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