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Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

RecruitingNAAges 18 Years - 65 YearsAllUnity Health Toronto
NCT04754022 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. ≥18 and ≤65 years of age 2. Planned cardiac surgery using cardiopulmonary bypass 3. Informed consent obtained 4. Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more Exclusion Criteria: 1. Patients who refuse participation 2. Patients who are unable to receive or who refuse blood products 3. Patients who are involved in a preoperative autologous pre-donation program 4. Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device 5. Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential)
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What it tests

  • Restrictive Transfusion Strategy
  • Liberal transfusion strategy
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Where

54 sites
Maine Medical Center
Portland, United States
The Cooper Health System
Camden, United States
Columbia University
New York, United States
Thomas Jefferson University
Philadelphia, United States
Royal Adelaide Hospital
Adelaide, Australia
Royal Prince Alfred hospital
Camperdown, Australia
Prince of Wales Hospital
Randwick, Australia
Westmead Hospital
Westmead, Australia

…and 46 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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