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sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.

RecruitingNAAges 18 Years - anyFemaleFundació Institut de Recerca de l'Hospital de la …
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In plain words

What the trial is, and whether it could suit you

* Preeclampsia (PE) affects \~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world. * Term PE accounts for 70% of all PE and a large proportion of maternal-fetal morbidity related with this condition. Prediction and prevention of term PE remains unsolved. * Previously proposed approaches are based on combined screening and/or prophylactic drugs, but these policies are unlikely to be implementable in many world settings. * Recent evidence shows that sFlt1-PlGF ratio at 35-37w predicts term PE with 80% detection rate. * Likewise, recent studies demonstrate that induction of labor (IOL) from 37w is safe. * The investigators hypothesize that a single-step universal screening for term PE based on sFlt1/PlGF ratio at 35-37w followed by IOL from 37w would redu

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Nulliparous women * Singleton pregnancies * \>18 years old * 35.0-36.6 weeks of gestation * Maternal written consent form Exclusion Criteria: * Fetuses/neonates with major malformations or genetic anomalies that could modify the timing of delivery or has an impact on obstetric outcome * Suspected fetal growth restriction (estimated fetal weight \<3 centile or between the 3rd and 10th centile together with abnormal Doppler in the mean uterine artery Doppler pulsatility index, or in umbilical artery pulsatility index or in the middle cerebral artery or in the cerebral umbilical index (CPR)) * Participation in another interventional study that could modify the timing of delivery.
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What it tests

  • sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
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Where

21 sites
CHU Liège
Liège, Belgium
Clinica del Prado SAS
Bogotá, Colombia
Institute for the Care of Mother and Child
Prague, Czechia
Medicina Fetal Quito
Quito, Ecuador
Maulana Azad Medical College (MAMC)
New Delhi, India
All India Institute of Medical Sciences (AIIMS) Ansari Nagar
New Delhi, India
Vardhman Mahavir Medical College (VMMC)
New Delhi, India
Hospital Gineco-Obstetricia nº4
Mexico City, Mexico

…and 13 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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