💬In plain words
What the trial is, and whether it could suit you
Borderline personality disorder (BPD) is a common mental disorder in adolescents with significant individual and societal repercussions, characterized over the long term by emotional hyperresponsiveness, relational instability, identity disturbances and self-aggressive behavior. The etiology of BPD is multifactorial and involves exposure to traumatic life events, which are present in the majority of cases. This explains the very common co-morbidity between BPD and post-traumatic stress disorder (PTSD), which involves emotionally painful memory relapses of one or more traumatic events, associated with an emotional trauma avoidance syndrome (s). ) and hypervigilance. Brain imaging studies in adolescents with BPD have shown decreases in the volume of gray matter within the frontolimbic network, as well as a decrease in frontolimbic white matter bundles. These brain changes are considered to
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
For the 3 groups:
* female
* Age between 13 and 17 years inclusive
* Oral and written comprehension of the French language
* Affiliation to the social security scheme
* Informed consent signed by the legal representatives holding the exercise of parental authority and the adolescent herself
For patients:
* Diagnosis of borderline personality disorder according to the criteria of the Diagnostic and Statistical Manual for mental disorders, fifth edition (DSM-5; American Psychiatric Association, 2013; SIDP-IV)
* Level of general psychopathology compatible with participation in the study (score\> 20 on the CGA-S)
TB + / PTSD + group:
\- Post-traumatic stress disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL)
In the control group :
* Absence of mental disorder according to DSM-5 criteria (American Psychiatric Association, 2013; K-SADS-PL and SIDP-IV)
* Oral and written comprehension of the French language
* Informed consent signed by the legal representative, the holder (s) of the exercise of parental authority and the adolescent herself
Exclusion Criteria:
* \- Illiteracy / illiteracy
* Sensory disorder (visual, auditory)
* Severe chronic psychiatric comorbidity: autism spectrum disorder, intellectual disability, schizophrenia spectrum disorder and other psychotic disorders, bipolar disorder
* Severe or current brain pathology (chronic neurological disease, encephalitis, history of severe head trauma), alertness disorder
* History of anoxic coma
* Contraindication to MRI (magnetic foreign body, claustrophobia, contraindication to prolonged lying down)
* Severe physical pathology in progress
* Moving outside the Normandy region planned within 18 months
* The inclusion of the subject in another biomedical research protocol (during the present study)
* Intellectual deficit (IQ \<70)
* Pregnant or breastfeeding women
Caen University Hospital
Caen, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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