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Study of the Role of the Induced Membrane in the Reconstruction of Bone Loss in the Limbs

Recruitingn/aAges 18 Years - anyAllDirection Centrale du Service de Santé des Armées
NCT04883502 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Masquelet's induced membrane technique is a two-stage reconstructive surgery for severe bone fractures commonly used by military orthopedists. The particularity of this technique relies on the synthesis of a biological membrane induced by the transient implantation of a surgical cement (= 1st stage surgery). The presence of the induced membrane in the reconstruction space defines a microenvironment or "biological chamber" favourable to osteogenesis, positively influencing the repair of the lesion after implantation of an autologous bone graft (= 2nd stage of surgery). In view of the excellent clinical results obtained with this procedure, the Masquelet technique has gradually become a reference treatment in the field of orthopedic and trauma surgery. However, orthopedic surgeons sometimes observe failures in bone consolidation. To our knowledge, the role played by induced membrane in t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Patient with traumatic bone loss * Patient eligible for the induced membrane technique Exclusion Criteria: * Patients with post-tumor bone loss * Patients who are immunocompromised or under immunosuppressive treatment * Patients with chronic inflammatory disease (diabetes, inflammatory bowel disease) * Patients with collagenosis * Patient with a contraindication to sampling * Pregnant or breastfeeding women
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What it tests

  • Blood sample collection
  • Other biological sample collection
  • Surgical waste collection
  • Radiological examination and functional exploration
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Where

2 sites
Hôpital d'Instruction des Armées Percy
Clamart, France
Hôpital d'Instruction des Armées Bégin
Saint-Mandé, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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