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Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cell Lung Cancer

Recruitingn/aAges any - anyAllM.D. Anderson Cancer Center
NCT04913311 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study looks at the side effects of chemotherapy and radiation (chemoradiation) followed by immunotherapy in patients with non-small cell lung cancer, with a particular focus on lung inflammation (pneumonitis). By collecting blood, stool and saliva samples, and data from lung function tests, researchers may be able to create a database of information about treatment and side effects in patients with non-small cell lung cancer who are receiving chemoradiation followed by immunotherapy. The information gained from this study may also help researchers find signs of problems with lung function earlier rather than later, since lung function is checked more often than routine care. This may improve how quickly these issues can be treated, and future patients may benefit from what is learned.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Newly-diagnosed NSCLC patients who will be undergoing concurrent chemotherapy and radiotherapy (XRT) followed by immune checkpoint inhibitors (CPI) therapy with durvalumab, as per the PACIFIC trial * Willing to undergo all treatment and evaluation at MD Anderson Cancer Center (MDACC) * Has access to a smartphone with the ability to transmit data via wireless connection or through their personal cellular plan * Able and willing to perform home spirometry (HS) weekly without absolute contraindications to performing spirometry
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What it tests

  • Biospecimen Collection
  • Bronchoscopy with Bronchoalveolar Lavage
  • Chemoradiotherapy
  • Computed Tomography
  • Diagnostic Laboratory Biomarker Analysis
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Where

1 site
M D Anderson Cancer Center
Houston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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