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Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

Recruitingn/aAges 8 Years - anyAllHugo W. Moser Research Institute at Kennedy Krieg…
NCT05197946 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.

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📋 Eligibility rules (as published)
Participants with CP (Survey-only): Inclusion Criteria: * Individual 8+ years of age * Diagnosis of cerebral palsy Exclusion Criteria: -None Neurotypical participants: (Survey-only): Inclusion Criteria: * Individual 8+ years of age * Adult subject able to indicate understanding and affirmative consent OR Adult/child subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents Exclusion Criteria: -Clinically-significant neurologic or developmental diagnosis Participants with CP (Survey and MRI): Inclusion Criteria: * Individual 8+ years of age * Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents * Diagnosis of cerebral palsy * Clinical imaging demonstrating isolated periventricular white matter injury * Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury * Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI Exclusion Criteria: -None Neurotypical participants (Survey and MRI): Inclusion Criteria: * Individual 8+ years of age * Adult subject able to indicate understanding and affirmative consent * Able to lie still in scanner for 1.5 hours and be able to have MRI Exclusion Criteria: -Clinically-significant neurologic or developmental diagnosis
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What it tests

  • MRI
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Where

4 sites
F.M. Kirby Center
Baltimore, United States
Mt. Washington Pediatric Hospital
Baltimore, United States
Johns Hopkins Hospital
Baltimore, United States
Kennedy Krieger Institute
Baltimore, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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