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Fexofenadine in Patients With Active Rheumatoid Arthritis

RecruitingPhase 1, Phase 2Ages 18 Years - 60 YearsAllOctober 6 University
NCT05264025 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

Rheumatoid arthritis (RA) is an inflammatory autoimmune polyarthritis affecting โˆผ1% of the world population, resulting in the loss of joint function and progressive structural damage in affected joints. Fexofenadine has been widely used to treat various allergic diseases, like allergic rhinitis, conjunctivitis and chronic idiopathic urticaria. the molecular mechanisms underlying fexofenadine mediated inhibition of TNF-ฮฑ signalling

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria * Moderate to severe RA (disease activity score-28 joints: DAS-28 \> 3.2) were recruited. * Age between 18 - 60 years having active disease according to the diagnosis of an experienced rheumatologist, being under treatment with disease-modifying anti-rheumatic drugs (DMARDs), not receiving cytokine inhibitors * Signing informed consent and willingness of the participant to accept randomization to any assigned treatment arm. Exclusion Criteria: * History of biological DMARDS. * History/presence of acute heart disease, liver and kidney diseases, COPD * Intolerance or allergy to fexofenadine or methotrexate * Alcohol abuse * Any changes in using medication (changing the dosage or type of medicines * Receive hormone replacement therapy, warfarin, and other anticoagulants
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What it tests

  • Fexofenadine
  • Placebo
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Where

2 sites
Beni-Suef Hospital
Banฤซ Suwayf, Egypt
Faculty of Medicine - Beni Suef Hospital
Banฤซ Suwayf, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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