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Adjuvant Concurrent Chemoradiotherapy Versus Radiotherapy in Early-stage Cervical Cancer Patients

RecruitingPhase 3Ages 18 Years - 80 YearsFemaleRuijin Hospital
NCT05277688 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To evaluate if adjuvant concurrent chemoradiotherapy is associated with a recurrence-free survival benefit in comparison with radiotherapy alone in selected intermediate risk cervical cancer after radical surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: * • 18 Years to 80 Years * Histologically proven cervical cancer, FIGO stage Ia2-IIb,and no previous chemotherapy and radiotherapy * Accepted radical hysterectomy 3-4 weeks before * Karnofsky score \>70 * Postoperative pathology with one of the three risk factors criterials: (1) lympho-vascular space invasion(LVSI+) and deep 1/3 stromal invasion; (2 ) LVSI(+) and middle 1/3 stromal invasion, and tumor size≥4cm (3)Non-squamous cell carcinoma; * Examination results showed no radiation or chemotherapy contraindication * Willing to accept treatment * Ability to comply with trial requirements Exclusion Criteria: * • Postoperative residual * Postoperative recurrence or metastasis * Pelvic lymph node metastasis * parametrial invasion * positive surgical margin * Without lymph node dissection * Postoperative pathology showed aortic lymph node metastasis * Examination results showed radiotherapy contraindications * No indications for radiotherapy
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What it tests

  • adjuvant concurrent chemoradiotherapy
  • radiotherapy
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Where

2 sites
Ruijin Hospital, Shanghai jiaotong univestigy school of medicine
Shanghai, China
Ruijin Hospital, Shanghai jiaotong univestigy school of medicine
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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