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Genetic Predisposition in Cerebral Palsy

RecruitingNAAges 2 Years - 15 YearsAllHospices Civils de Lyon
NCT05317234 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cerebral palsy (CP) is a major neurodevelopmental disorder with an estimated prevalence of approximately one in 500 children. It is characterised by permanent developmental disorders of movement and posture, responsible for activity limitations, caused by non-progressive damage to the brain of the fetus, newborn or infant during development. The neurobiological mechanisms involved in CP remain poorly understood, although the interruption of cerebral oxygen supply during pregnancy or at the time of delivery is classically considered to be the main factor causing neurodevelopmental sequelae. CP also occurs in full-term infants without a clearly identifiable etiology. Data from the literature suggest the existence of other pathophysiological processes than only acquired brain lesions related to pregnancy and delivery, such as genetic or epigenetic factors. According to some research teams,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Child between 2 and 15 years old with a clinical diagnostic of cerebral paralysis with unilateral or bilateral somatic involvement * Child born from 34 SA * Agreement of the legal representatives for the genetic study * Both parents available for a parental genetic study (if detection of class 3 variant) * Affiliation to the social security system Exclusion Criteria: * Genetic syndrome identified or malformative or infectious etiologies identified * Neonatal encephalopathy criteria in a clear obstetrical etiological context responsible for major perinatal anoxia with Sarnat 2 or 3 * Unilateral motor disorders in perinatal stroke of identified etiology (coagulation anomaly)
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What it tests

  • Whole-exome sequencing
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Where

2 sites
Service de Médecine Physique et Réadaptation Pédiatrique - Hôpital Femme-Mère-Enfant
Bron, France
Service de médecine physique et réadaptative pédiatrique, Pôle pédiatrie-Génétique - Hôpital Couple-Enfant
Grenoble, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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